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UBA domain containing 2

Summary

Gene Symbol

UBAC2

Organism

Homo sapiens (human)

External Links

NCBI Gene

337867

PubChem

337867

Alliance of Genome Resources

HGNC:20486

JoGo

UBAC2

TogoVar

UBAC2

Annotation

Keyword

Alternative splicing
Endoplasmic reticulum
Glycoprotein
Proteomics identification
Reference proteome
Signal
Transmembrane helix
Wnt signaling pathway

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q8NBM4	Phosphoglycerate dehydrogenase-like protein 1
A8K2S7	Phosphoglycerate dehydrogenase-like protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
Wnt signaling pathway	IEA
protein localization to endoplasmic reticulum	IDA	23297223
negative regulation of canonical Wnt signaling pathway	IMP	31073040
negative regulation of retrograde protein transport, ER to cytosol	IMP	25660456

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endoplasmic reticulum

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endoplasmic reticulum

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endoplasmic reticulum

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of localization [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

regulation of intracellular protein transport [inference]

regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

regulation of retrograde protein transport, ER to cytosol [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

regulation of retrograde protein transport, ER to cytosol [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

regulation of intracellular protein transport [inference]

regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

regulation of retrograde protein transport, ER to cytosol [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

regulation of retrograde protein transport, ER to cytosol [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of intracellular transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of intracellular transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

regulation of intracellular protein transport [inference]

regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

regulation of retrograde protein transport, ER to cytosol [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

regulation of retrograde protein transport, ER to cytosol [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA	23297223
endoplasmic reticulum membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 2** entries
GO Term	Evidence Code	PMID
serine-type endopeptidase activity	IBA
protein binding	IPI	22119785 25416956 28514442 31073040 32814053

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ubiquitin-associated domain-containing protein

Functional Category

J: Translation, ribosomal structure and biogenesis
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying 1 entry
Gene Ontology
serine-type endopeptidase activity

Displaying **all 3** entries
InterPro
Rhomboid-like superfamily
UBA-like superfamily
Ubiquitin-associated domain

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements