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ectonucleotide pyrophosphatase/phosphodiesterase 7

Summary

Gene Symbol

ENPP7

Aliases

NPP7
alk-SMase
alkaline sphingomyelinase

Organism

Homo sapiens (human)

External Links

NCBI Gene

339221

HGNC

23764

KEGG Gene ID

hsa:339221

PubChem

339221

Alliance of Genome Resources

HGNC:23764

Annotation

Keyword

3D-structure
Cell membrane
Direct protein sequencing
Glycoprotein
Hydrolase
Lipid metabolism
Metal-binding
Reference proteome
Signal
Transmembrane helix
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
Q6UWV6	Alkaline sphingomyelin phosphodiesterase Intestinal alkaline sphingomyelinase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
sphingomyelin metabolic process	IDA	12671034 12885774 28292932
fatty acid homeostasis	ISS
positive regulation of intestinal cholesterol absorption	ISS
positive regulation of sphingomyelin catabolic process	ISS
negative regulation of DNA replication	IDA	12671034

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

sphingomyelin metabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingomyelin metabolic process

glycosphingolipid metabolic process [inference]

glycosphingolipid catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

carbohydrate derivative catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

sphingolipid metabolic process [inference]

sphingomyelin metabolic process

glycosphingolipid metabolic process [inference]

glycosphingolipid catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

phospholipid metabolic process [inference]

sphingomyelin metabolic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

sphingolipid metabolic process [inference]

sphingomyelin metabolic process

glycosphingolipid metabolic process [inference]

glycosphingolipid catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

phospholipid metabolic process [inference]

sphingomyelin metabolic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

sphingolipid metabolic process [inference]

sphingomyelin metabolic process

glycosphingolipid metabolic process [inference]

glycosphingolipid catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

phospholipid metabolic process [inference]

sphingomyelin metabolic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process

carbohydrate derivative metabolic process [inference]

carbohydrate derivative catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingomyelin metabolic process

glycosphingolipid metabolic process [inference]

glycosphingolipid catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

carbohydrate derivative catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosphingolipid catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

sphingolipid metabolic process [inference]

sphingomyelin metabolic process

glycosphingolipid metabolic process [inference]

glycosphingolipid catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

phospholipid metabolic process [inference]

sphingomyelin metabolic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process

multicellular organismal process [inference]

digestion [inference]

lipid digestion

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

fatty acid homeostasis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of lipid biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of lipid catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of cellular catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of lipid catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of amide metabolic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of lipid catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of cellular catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of phospholipid catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of sphingomyelin catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of lipid catabolic process [inference]

positive regulation of lipid catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of phospholipid catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of sphingomyelin catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

negative regulation of DNA replication

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of cellular catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of cellular catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of phospholipid catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of sphingomyelin catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of phosphate metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of phospholipid metabolic process [inference]

regulation of phospholipid catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of sphingomyelin catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of membrane lipid metabolic process [inference]

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of sphingomyelin catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

negative regulation of DNA replication

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of amide metabolic process [inference]

positive regulation of amide metabolic process [inference]

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of sphingomyelin catabolic process [inference]

positive regulation of sphingomyelin catabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of amide metabolic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

negative regulation of DNA replication

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of lipid catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of lipid biosynthetic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of lipid catabolic process [inference]

positive regulation of lipid catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of phospholipid catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of sphingomyelin catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of phospholipid metabolic process [inference]

regulation of phospholipid catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of sphingomyelin catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of membrane lipid metabolic process [inference]

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of sphingomyelin catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

negative regulation of DNA replication

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of intestinal cholesterol absorption

regulation of cholesterol transport [inference]

regulation of intestinal cholesterol absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of cholesterol transport [inference]

positive regulation of intestinal cholesterol absorption

regulation of intestinal lipid absorption

regulation of intestinal cholesterol absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of intestinal absorption [inference]

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

regulation of intestinal absorption [inference]

positive regulation of intestinal absorption [inference]

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

regulation of intestinal lipid absorption

regulation of intestinal cholesterol absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

regulation of lipid localization [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of intestinal cholesterol absorption

regulation of cholesterol transport [inference]

regulation of intestinal cholesterol absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of cholesterol transport [inference]

positive regulation of intestinal cholesterol absorption

regulation of intestinal lipid absorption

regulation of intestinal cholesterol absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of lipid catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of cellular catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of lipid catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of amide metabolic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of cellular catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of intestinal absorption [inference]

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of multicellular organismal process [inference]

positive regulation of digestive system process [inference]

positive regulation of intestinal absorption [inference]

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

negative regulation of DNA replication

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of cellular catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of cellular catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of phospholipid catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of sphingomyelin catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of phosphate metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of phospholipid metabolic process [inference]

regulation of phospholipid catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of sphingomyelin catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of membrane lipid metabolic process [inference]

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of sphingomyelin catabolic process [inference]

positive regulation of sphingomyelin catabolic process

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

regulation of cellular component biogenesis [inference]

regulation of sphingolipid biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

regulation of ceramide biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phospholipid metabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of sphingolipid biosynthetic process [inference]

positive regulation of ceramide biosynthetic process

positive regulation of cellular catabolic process [inference]

positive regulation of phospholipid catabolic process [inference]

positive regulation of sphingomyelin catabolic process

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of digestive system process [inference]

positive regulation of digestive system process [inference]

positive regulation of intestinal absorption [inference]

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

regulation of intestinal absorption [inference]

positive regulation of intestinal absorption [inference]

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

regulation of intestinal lipid absorption

regulation of intestinal cholesterol absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of multicellular organismal process [inference]

positive regulation of digestive system process [inference]

positive regulation of intestinal absorption [inference]

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

Displaying **all 4** entries
GO Term	Evidence Code	PMID
membrane	NAS	12885774
Golgi apparatus	IDA	12671034
microvillus	IDA	12671034
plasma membrane	IDA TAS	15205117

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

actin-based cell projection [inference]

microvillus

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	32296183
zinc ion binding	IDA	28292932
phosphoric diester hydrolase activity	IDA	16255717
sphingomyelin phosphodiesterase activity	IDA TAS	12671034 12885774 16255717 28292932

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity [inference]

sphingomyelin phosphodiesterase activity

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity

sphingomyelin phosphodiesterase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying 1 entry
Gene Ontology
nucleoside triphosphate diphosphatase activity

Displaying **all 2** entries
InterPro
Alkaline-phosphatase-like, core domain superfamily
Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase

KEGG BRITE Database

Orthology

K12354

Name

ectonucleotide pyrophosphatase/phosphodiesterase family member 7 [EC:3.1.4.12]

References

Rhea

RHEA:19253

H₂O + a sphingomyelin

H⁺ + phosphocholine + an N-acylsphing-4-enine

Enzyme

3.1.4.12

PMID

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002902
Gene Name: ectonucleotide pyrophosphatase/phosphodiesterase 7

Ortholog

Displaying entries **1 - 10** of 61 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	238011		MGI:3027917	MOUSE04369
Rattus norvegicus	303729		RGD:1359324
Danio rerio	557756		ZFIN:ZDB-GENE-040724-13	DANRE03822
Danio rerio	557817		ZFIN:ZDB-GENE-130531-2	DANRE03839
Canis lupus familiaris	608627			CANLF18381
Macaca mulatta	717416			MACMU16024
Pan troglodytes	742055	9598_0:0047bd		PANTR15602
Saccharomyces cerevisiae S288C	856699		SGD:S000000742
Monodelphis domestica	100030901			MONDO13724
Ornithorhynchus anatinus	100087213			ORNAN00138

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements