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Wnt oncogene analog 4

Summary

Gene Symbol

Wnt4

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

34007

PubChem

34007

Alliance of Genome Resources

FB:FBgn0010453

Annotation

Keyword

Developmental protein
Disulfide bond
Extracellular matrix
Glycoprotein
Lipoprotein
Reference proteome
Signal
Wnt signaling pathway

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P40589	dWnt-4
D2NUH8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
establishment of planar polarity	IGI	15986451
neuron differentiation	IBA
salivary gland morphogenesis	IMP	17507403
germ-line stem-cell niche homeostasis	IMP	26452202
synaptic target inhibition	IMP	17764943

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation

cell fate commitment

cell motility [inference]

cell migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance [inference]

reproductive process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

female gonad development

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

germ-line stem-cell niche homeostasis

developmental process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

female gonad development

anatomical structure morphogenesis [inference]

establishment of tissue polarity [inference]

establishment of planar polarity

animal organ morphogenesis [inference]

gland morphogenesis [inference]

salivary gland morphogenesis

anatomical structure development [inference]

animal organ development [inference]

gonad development [inference]

female gonad development

reproductive structure development [inference]

gonad development [inference]

female gonad development

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation

cell fate commitment

locomotion [inference]

taxis [inference]

chemotaxis [inference]

negative chemotaxis [inference]

synaptic target inhibition

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

germ-line stem-cell niche homeostasis

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of hemocyte proliferation

regulation of developmental process [inference]

regulation of hemocyte proliferation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

regulation of cell population proliferation [inference]

regulation of hemocyte proliferation

regulation of multicellular organismal process [inference]

regulation of hemocyte proliferation

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular space	IBA
extracellular region	IEA ISM ISS NAS	11970894 7867502
cell surface	IDA	16369482

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cytokine activity	IBA
protein binding	IPI	15986451
signaling receptor binding	IEA ISS
frizzled binding	IBA IPI	12205098

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding

G protein-coupled receptor binding [inference]

frizzled binding

receptor ligand activity [inference]

cytokine activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Wnt

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
canonical Wnt signaling pathway
cell fate commitment
cytokine activity
neuron differentiation
signaling receptor binding

Displaying **all 3** entries
InterPro
Wnt protein, conserved site
Wnt, C-terminal domain
Wnt

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
cell surface	PMID:16369482

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:1612	breast cancer	Alliance of Genome Resources
DOID:1793	pancreatic cancer	Alliance of Genome Resources
DOID:4947	cholangiocarcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 48 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Homo sapiens	7483		HGNC:12778
Homo sapiens	7484		HGNC:12779
Mus musculus	22412		MGI:1197020
Caenorhabditis elegans	179217		WB:WBGene00003395
Mus musculus	216795		MGI:2446084
Rattus norvegicus	287357		RGD:1305018
Rattus norvegicus	303586		RGD:1309574
Danio rerio	565677		ZFIN:ZDB-GENE-080201-1
Danio rerio	751644		ZFIN:ZDB-GENE-060825-97
Drosophila ananassae	6496858	7217_1:002836

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Annotation

OrthoDB (Group)

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Acknowledgements