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wingless

Summary

Gene Symbol

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

34009

PubChem

34009

Alliance of Genome Resources

FB:FBgn0284084

Annotation

Keyword

Alternative splicing
Developmental protein
Disulfide bond
Extracellular matrix
Glycoprotein
Lipoprotein
Membrane
Morphogen
Reference proteome
Segmentation polarity protein
Signal
Synapse
Wnt signaling pathway

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P09615	Protein Wnt-1 Protein int-1 dInt-1 dWnt-1
I1WYH9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 62 in total

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GO Term	Evidence Code	PMID
positive regulation of cell population proliferation	IGI IMP	19176582 19809090
branching morphogenesis of an epithelial tube	IMP	11003842
wing cell fate specification	IMP	10860999 10995384
genital disc sexually dimorphic development	IMP	11290302 15893978
synaptic assembly at neuromuscular junction	IMP	23844193 24553932

GO Hierarchy

biological process

immune system process [inference]

hemocyte differentiation [inference]

larval lymph gland hemocyte differentiation [inference]

lymph gland crystal cell differentiation

crystal cell differentiation [inference]

lymph gland crystal cell differentiation

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

canonical Wnt signaling pathway

cell population proliferation [inference]

epithelial cell proliferation [inference]

epithelial cell proliferation involved in renal tubule morphogenesis [inference]

epithelial cell proliferation involved in Malpighian tubule morphogenesis

cell growth [inference]

unidimensional cell growth [inference]

cell elongation involved in imaginal disc-derived wing morphogenesis

cellular process involved in reproduction in multicellular organism [inference]

follicle cell of egg chamber development

cellular developmental process [inference]

cell fate specification [inference]

epithelial cell type specification, open tracheal system

cell fate specification involved in pattern specification [inference]

wing cell fate specification

cell differentiation [inference]

neuron differentiation

cardiocyte differentiation [inference]

cardioblast differentiation

hemocyte differentiation [inference]

larval lymph gland hemocyte differentiation [inference]

lymph gland crystal cell differentiation

crystal cell differentiation [inference]

lymph gland crystal cell differentiation

stem cell differentiation [inference]

cardioblast differentiation

renal filtration cell differentiation [inference]

nephrocyte differentiation [inference]

pericardial nephrocyte differentiation

Malpighian tubule tip cell differentiation

cell fate commitment

determination of imaginal disc primordium [inference]

determination of genital disc primordium

cell development [inference]

epithelial cell development [inference]

follicle cell of egg chamber development

neuroblast development

hemopoiesis [inference]

post-embryonic hemopoiesis [inference]

larval lymph gland hemopoiesis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

synapse assembly [inference]

synaptic assembly at neuromuscular junction

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly [inference]

synaptic assembly at neuromuscular junction

synapse organization

synapse assembly [inference]

synaptic assembly at neuromuscular junction

neuromuscular junction development [inference]

synaptic assembly at neuromuscular junction

reproductive process [inference]

developmental process involved in reproduction [inference]

cellular process involved in reproduction in multicellular organism [inference]

follicle cell of egg chamber development

multicellular organismal reproductive process [inference]

genital disc sexually dimorphic development

multicellular organismal process [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

memory [inference]

long-term memory

pattern specification process [inference]

regionalization [inference]

periodic partitioning [inference]

segment polarity determination

imaginal disc pattern formation [inference]

anterior/posterior pattern specification, imaginal disc

genital disc anterior/posterior pattern formation

dorsal/ventral pattern formation, imaginal disc

genital disc pattern formation [inference]

genital disc anterior/posterior pattern formation

anterior/posterior pattern specification [inference]

anterior/posterior pattern specification, imaginal disc

genital disc anterior/posterior pattern formation

dorsal/ventral pattern formation [inference]

dorsal/ventral pattern formation, imaginal disc

cuticle pattern formation [inference]

chitin-based larval cuticle pattern formation

behavior [inference]

learning or memory [inference]

memory [inference]

long-term memory

developmental process [inference]

developmental process involved in reproduction [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis [inference]

histoblast morphogenesis

unidimensional cell growth [inference]

cell elongation involved in imaginal disc-derived wing morphogenesis

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube

hindgut morphogenesis

post-embryonic animal morphogenesis [inference]

imaginal disc-derived wing margin morphogenesis

post-embryonic appendage morphogenesis [inference]

imaginal disc-derived wing morphogenesis

cell elongation involved in imaginal disc-derived wing morphogenesis

animal organ morphogenesis [inference]

imaginal disc morphogenesis [inference]

histoblast morphogenesis

sensory organ morphogenesis [inference]

eye morphogenesis [inference]

compound eye morphogenesis

appendage morphogenesis [inference]

imaginal disc-derived appendage morphogenesis [inference]

imaginal disc-derived wing morphogenesis

post-embryonic appendage morphogenesis [inference]

imaginal disc-derived wing morphogenesis

tube morphogenesis [inference]

tube fusion [inference]

branch fusion, open tracheal system

spiracle morphogenesis, open tracheal system

embryonic morphogenesis [inference]

morphogenesis of embryonic epithelium [inference]

dorsal closure

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of embryonic epithelium [inference]

dorsal closure

morphogenesis of an epithelial fold [inference]

morphogenesis of an epithelial bud [inference]

Malpighian tubule bud morphogenesis

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube

mesoderm morphogenesis

anatomical structure formation involved in morphogenesis [inference]

tube formation [inference]

epithelial tube formation [inference]

Malpighian tubule bud morphogenesis

animal organ formation [inference]

heart formation

anatomical structure development [inference]

ventral midline development

tissue development [inference]

epithelium development [inference]

renal tubule development [inference]

Malpighian tubule development [inference]

posterior Malpighian tubule development

regeneration [inference]

tissue regeneration

tube development [inference]

renal tubule development [inference]

Malpighian tubule development [inference]

posterior Malpighian tubule development

cell development [inference]

epithelial cell development [inference]

follicle cell of egg chamber development

neuroblast development

hemopoiesis [inference]

post-embryonic hemopoiesis [inference]

larval lymph gland hemopoiesis

animal organ development [inference]

imaginal disc development

heart development

muscle organ development [inference]

visceral muscle development [inference]

larval visceral muscle development

hematopoietic or lymphoid organ development [inference]

lymph gland development

proboscis development

gland development [inference]

lymph gland development

Malpighian tubule development [inference]

posterior Malpighian tubule development

muscle structure development [inference]

muscle organ development [inference]

visceral muscle development [inference]

larval visceral muscle development

cellular developmental process [inference]

cell fate specification [inference]

epithelial cell type specification, open tracheal system

cell fate specification involved in pattern specification [inference]

wing cell fate specification

cell differentiation [inference]

neuron differentiation

cardiocyte differentiation [inference]

cardioblast differentiation

hemocyte differentiation [inference]

larval lymph gland hemocyte differentiation [inference]

lymph gland crystal cell differentiation

crystal cell differentiation [inference]

lymph gland crystal cell differentiation

stem cell differentiation [inference]

cardioblast differentiation

renal filtration cell differentiation [inference]

nephrocyte differentiation [inference]

pericardial nephrocyte differentiation

Malpighian tubule tip cell differentiation

cell fate commitment

determination of imaginal disc primordium [inference]

determination of genital disc primordium

cell development [inference]

epithelial cell development [inference]

follicle cell of egg chamber development

neuroblast development

hemopoiesis [inference]

post-embryonic hemopoiesis [inference]

larval lymph gland hemopoiesis

growth [inference]

cell growth [inference]

unidimensional cell growth [inference]

cell elongation involved in imaginal disc-derived wing morphogenesis

developmental growth [inference]

developmental growth involved in morphogenesis [inference]

unidimensional cell growth [inference]

cell elongation involved in imaginal disc-derived wing morphogenesis

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of hemocyte differentiation

positive regulation of immune system process [inference]

positive regulation of hemocyte differentiation [inference]

positive regulation of crystal cell differentiation

regulation of hemocyte differentiation [inference]

regulation of crystal cell differentiation [inference]

positive regulation of crystal cell differentiation

negative regulation of hemocyte differentiation

positive regulation of hemocyte differentiation [inference]

positive regulation of crystal cell differentiation

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of DNA endoreduplication

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of DNA endoreduplication

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of DNA endoreduplication

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of DNA endoreduplication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of DNA endoreduplication

regulation of DNA-templated DNA replication [inference]

regulation of DNA endoreduplication [inference]

negative regulation of DNA endoreduplication

negative regulation of DNA-templated DNA replication [inference]

negative regulation of DNA endoreduplication

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of DNA endoreduplication

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of DNA endoreduplication

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of DNA endoreduplication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of DNA endoreduplication

regulation of DNA-templated DNA replication [inference]

regulation of DNA endoreduplication [inference]

negative regulation of DNA endoreduplication

negative regulation of DNA-templated DNA replication [inference]

negative regulation of DNA endoreduplication

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of DNA endoreduplication

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of DNA endoreduplication

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of DNA endoreduplication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of DNA endoreduplication

regulation of DNA-templated DNA replication [inference]

regulation of DNA endoreduplication [inference]

negative regulation of DNA endoreduplication

negative regulation of DNA-templated DNA replication [inference]

negative regulation of DNA endoreduplication

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of DNA endoreduplication

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of DNA endoreduplication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of DNA endoreduplication

regulation of DNA-templated DNA replication [inference]

regulation of DNA endoreduplication [inference]

negative regulation of DNA endoreduplication

negative regulation of DNA-templated DNA replication [inference]

negative regulation of DNA endoreduplication

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of DNA endoreduplication

regulation of growth [inference]

positive regulation of growth [inference]

positive regulation of developmental growth [inference]

positive regulation of imaginal disc growth

regulation of developmental growth [inference]

regulation of imaginal disc growth [inference]

positive regulation of imaginal disc growth

positive regulation of developmental growth [inference]

positive regulation of imaginal disc growth

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of hemocyte differentiation [inference]

positive regulation of crystal cell differentiation

positive regulation of growth [inference]

positive regulation of developmental growth [inference]

positive regulation of imaginal disc growth

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of stem cell proliferation

positive regulation of programmed cell death

positive regulation of retinal cell programmed cell death [inference]

positive regulation of compound eye retinal cell programmed cell death

positive regulation of cell differentiation [inference]

positive regulation of hemocyte differentiation [inference]

positive regulation of crystal cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of hemocyte differentiation [inference]

positive regulation of crystal cell differentiation

positive regulation of retinal cell programmed cell death [inference]

positive regulation of compound eye retinal cell programmed cell death

positive regulation of developmental growth [inference]

positive regulation of imaginal disc growth

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of hemocyte differentiation

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of DNA endoreduplication

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of DNA endoreduplication

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of DNA endoreduplication

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of DNA endoreduplication

negative regulation of cell differentiation [inference]

negative regulation of cell fate commitment [inference]

negative regulation of cell fate specification

negative regulation of hemocyte differentiation

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of DNA endoreduplication

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell fate commitment [inference]

negative regulation of cell fate specification

negative regulation of hemocyte differentiation

regulation of developmental process [inference]

regulation of cell fate commitment [inference]

negative regulation of cell fate commitment [inference]

negative regulation of cell fate specification

regulation of cell fate specification [inference]

negative regulation of cell fate specification

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell fate commitment [inference]

negative regulation of cell fate specification

negative regulation of hemocyte differentiation

positive regulation of cell differentiation [inference]

positive regulation of hemocyte differentiation [inference]

positive regulation of crystal cell differentiation

regulation of hemocyte differentiation [inference]

regulation of crystal cell differentiation [inference]

positive regulation of crystal cell differentiation

negative regulation of hemocyte differentiation

positive regulation of hemocyte differentiation [inference]

positive regulation of crystal cell differentiation

regulation of retinal cell programmed cell death [inference]

regulation of compound eye retinal cell programmed cell death [inference]

positive regulation of compound eye retinal cell programmed cell death

positive regulation of retinal cell programmed cell death [inference]

positive regulation of compound eye retinal cell programmed cell death

regulation of developmental growth [inference]

regulation of imaginal disc growth [inference]

positive regulation of imaginal disc growth

positive regulation of developmental growth [inference]

positive regulation of imaginal disc growth

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell fate commitment [inference]

negative regulation of cell fate specification

negative regulation of hemocyte differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of hemocyte differentiation [inference]

positive regulation of crystal cell differentiation

positive regulation of retinal cell programmed cell death [inference]

positive regulation of compound eye retinal cell programmed cell death

positive regulation of developmental growth [inference]

positive regulation of imaginal disc growth

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

canonical Wnt signaling pathway

regulation of cell fate commitment [inference]

negative regulation of cell fate commitment [inference]

negative regulation of cell fate specification

regulation of cell fate specification [inference]

negative regulation of cell fate specification

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of DNA endoreduplication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of DNA endoreduplication

regulation of DNA-templated DNA replication [inference]

regulation of DNA endoreduplication [inference]

negative regulation of DNA endoreduplication

negative regulation of DNA-templated DNA replication [inference]

negative regulation of DNA endoreduplication

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of DNA endoreduplication

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of DNA endoreduplication

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of stem cell proliferation

regulation of stem cell proliferation

positive regulation of stem cell proliferation

regulation of programmed cell death [inference]

positive regulation of programmed cell death

positive regulation of retinal cell programmed cell death [inference]

positive regulation of compound eye retinal cell programmed cell death

regulation of retinal cell programmed cell death [inference]

regulation of compound eye retinal cell programmed cell death [inference]

positive regulation of compound eye retinal cell programmed cell death

positive regulation of retinal cell programmed cell death [inference]

positive regulation of compound eye retinal cell programmed cell death

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell fate commitment [inference]

negative regulation of cell fate specification

negative regulation of hemocyte differentiation

positive regulation of cell differentiation [inference]

positive regulation of hemocyte differentiation [inference]

positive regulation of crystal cell differentiation

regulation of hemocyte differentiation [inference]

regulation of crystal cell differentiation [inference]

positive regulation of crystal cell differentiation

negative regulation of hemocyte differentiation

positive regulation of hemocyte differentiation [inference]

positive regulation of crystal cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of stem cell proliferation

positive regulation of programmed cell death

positive regulation of retinal cell programmed cell death [inference]

positive regulation of compound eye retinal cell programmed cell death

positive regulation of cell differentiation [inference]

positive regulation of hemocyte differentiation [inference]

positive regulation of crystal cell differentiation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of DNA endoreduplication

negative regulation of cell differentiation [inference]

negative regulation of cell fate commitment [inference]

negative regulation of cell fate specification

negative regulation of hemocyte differentiation

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of DNA endoreduplication

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

negative regulation of cell cycle process [inference]

negative regulation of DNA endoreduplication

regulation of DNA endoreduplication [inference]

negative regulation of DNA endoreduplication

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of DNA endoreduplication

regulation of multicellular organismal process [inference]

regulation of hemocyte differentiation [inference]

regulation of crystal cell differentiation [inference]

positive regulation of crystal cell differentiation

negative regulation of hemocyte differentiation

positive regulation of hemocyte differentiation [inference]

positive regulation of crystal cell differentiation

regulation of pigmentation [inference]

regulation of developmental pigmentation [inference]

regulation of eye pigmentation [inference]

regulation of compound eye pigmentation

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GO Term	Evidence Code	PMID
multivesicular body	IDA	18430784
early endosome	IDA	16530179
late endosome	IDA	16530179
terminal bouton	IDA	24046358
plasma membrane	IDA	18430784

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

membrane microdomain [inference]

membrane raft

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

late endosome

multivesicular body

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

late endosome

multivesicular body

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

late endosome

multivesicular body

presynapse [inference]

terminal bouton

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GO Term	Evidence Code	PMID
protein binding	IPI	10660608 11821428 18193037 22285813
heparan sulfate proteoglycan binding	IPI	25360738
signaling receptor binding	IEA
frizzled binding	IBA IDA IPI	12205098 16291792 22285813 8717036
extracellular matrix binding	IDA	8909553

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding

G protein-coupled receptor binding [inference]

frizzled binding

receptor ligand activity

proteoglycan binding [inference]

heparan sulfate proteoglycan binding

extracellular matrix binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding

proteoglycan binding [inference]

heparan sulfate proteoglycan binding

sulfur compound binding [inference]

heparan sulfate proteoglycan binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Wnt

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
canonical Wnt signaling pathway
cell fate commitment
cytokine activity
neuron differentiation
signaling receptor binding

Displaying **all 3** entries
InterPro
Wnt protein, conserved site
Wnt, C-terminal domain
Wnt

Alliance of Genome Resources

Expression

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Location	References
late endosome	PMID:16530179
type Ib terminal bouton	PMID:12419243 PMID:23144627
synaptic cleft	PMID:23144627
early endosome	PMID:16530179
terminal bouton	PMID:24046358
membrane raft	PMID:15166250
multivesicular body	PMID:18430784
plasma membrane	PMID:18430784
endoplasmic reticulum	PMID:18430784
cell surface	PMID:8717036

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0110347	osteogenesis imperfecta type 15	Alliance of Genome Resources
DOID:1612	breast cancer	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 44 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Homo sapiens	7471		HGNC:12774
Mus musculus	22408		MGI:98953
Rattus norvegicus	24881		RGD:1597195
Danio rerio	30128		ZFIN:ZDB-GENE-980526-526
Caenorhabditis elegans	173399		WB:WBGene00000857
Drosophila pseudoobscura	4817285	7237_0:0025ab
Drosophila ananassae	6508748	7217_1:0029b6
Drosophila yakuba	6526961	7245_1:0011dc
Drosophila erecta	6543349	7220_1:001b31
Drosophila grimshawi	6567089	7222_1:001164

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements