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R-spondin 2

Summary

Gene Symbol

RSPO2

Organism

Homo sapiens (human)

External Links

NCBI Gene

340419

PubChem

340419

Alliance of Genome Resources

HGNC:28583

Annotation

Keyword

3D-structure
Alternative splicing
Developmental protein
Disease variant
Disulfide bond
Glycoprotein
Heparin-binding
Proteomics identification
Reference proteome
Secreted
Sensory transduction
Signal
Wnt signaling pathway

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B3KVP3
Q6UXX9	Roof plate-specific spondin-2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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2

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GO Term	Evidence Code	PMID
osteoblast differentiation	IEA
positive regulation of Wnt signaling pathway	NAS	24431302
positive regulation of Wnt signaling pathway	IDA	29769720
bone mineralization	IEA
embryonic forelimb morphogenesis	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

canonical Wnt signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

neuron differentiation [inference]

dopaminergic neuron differentiation

multicellular organismal process [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

epithelial tube branching involved in lung morphogenesis

organ growth [inference]

lung growth

developmental process [inference]

anatomical structure morphogenesis [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

epithelial tube branching involved in lung morphogenesis

animal organ morphogenesis [inference]

cartilage morphogenesis [inference]

trachea cartilage morphogenesis

appendage morphogenesis [inference]

limb morphogenesis [inference]

embryonic limb morphogenesis [inference]

forelimb morphogenesis [inference]

embryonic forelimb morphogenesis

hindlimb morphogenesis [inference]

embryonic hindlimb morphogenesis

embryonic appendage morphogenesis [inference]

embryonic limb morphogenesis [inference]

tube morphogenesis [inference]

branching morphogenesis of an epithelial tube [inference]

epithelial tube branching involved in lung morphogenesis

embryonic morphogenesis [inference]

embryonic appendage morphogenesis [inference]

embryonic limb morphogenesis [inference]

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

epithelial tube branching involved in lung morphogenesis

cartilage morphogenesis [inference]

trachea cartilage morphogenesis

anatomical structure development [inference]

tissue development [inference]

biomineral tissue development [inference]

bone mineralization

appendage development [inference]

limb development

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

neuron differentiation [inference]

dopaminergic neuron differentiation

growth [inference]

developmental growth [inference]

organ growth [inference]

lung growth

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

negative regulation of biological process [inference]

negative regulation of developmental process [inference]

negative regulation of animal organ morphogenesis [inference]

negative regulation of odontogenesis [inference]

negative regulation of odontogenesis of dentin-containing tooth

negative regulation of multicellular organismal process [inference]

negative regulation of animal organ morphogenesis [inference]

negative regulation of odontogenesis [inference]

negative regulation of odontogenesis of dentin-containing tooth

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of animal organ morphogenesis [inference]

regulation of odontogenesis [inference]

negative regulation of odontogenesis [inference]

negative regulation of odontogenesis of dentin-containing tooth

regulation of odontogenesis of dentin-containing tooth [inference]

negative regulation of odontogenesis of dentin-containing tooth

negative regulation of animal organ morphogenesis [inference]

negative regulation of odontogenesis [inference]

negative regulation of odontogenesis of dentin-containing tooth

negative regulation of developmental process [inference]

negative regulation of animal organ morphogenesis [inference]

negative regulation of odontogenesis [inference]

negative regulation of odontogenesis of dentin-containing tooth

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

canonical Wnt signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of animal organ morphogenesis [inference]

negative regulation of odontogenesis [inference]

negative regulation of odontogenesis of dentin-containing tooth

Displaying **all 4** entries
GO Term	Evidence Code	PMID
extracellular region	NAS	24431302
extracellular region	TAS
extracellular space	IBA
cell surface	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
signaling receptor binding	IPI	22615920
protein binding	IPI	25416956 29769720 32296183 32814053
heparin binding	IEA
BMP receptor binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding

receptor serine/threonine kinase binding [inference]

transmembrane receptor protein serine/threonine kinase binding [inference]

BMP receptor binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

R-spondin

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
heparin binding

Displaying **all 5** entries
InterPro
Furin-like repeat
Growth factor receptor cysteine-rich domain superfamily
R-spondin, Fu-CRD domain
Thrombospondin type-1 (TSP1) repeat superfamily
Thrombospondin type-1 (TSP1) repeat