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MIRAGE
isocitrate dehydrogenase (NADP(+)) 2
Summary
- Gene Symbol
-
- IDH2
- Aliases
-
- IDH-2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Alternative splicing
- Disease variant
- Glyoxylate bypass
- Magnesium
- Manganese
- Metal-binding
- Mitochondrion
- NADP
- Oxidoreductase
- Reference proteome
- Transit peptide
- Tricarboxylic acid cycle
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| NADP metabolic process |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| mitochondrion | ||
| mitochondrion | ||
| mitochondrion | ||
| mitochondrion | ||
| mitochondrial matrix |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| magnesium ion binding | ||
| isocitrate dehydrogenase (NADP+) activity | ||
| isocitrate dehydrogenase (NADP+) activity | ||
| isocitrate dehydrogenase (NADP+) activity | ||
| isocitrate dehydrogenase (NADP+) activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- isocitrate dehydrogenase
- Functional Category
-
- E: Amino acid transport and metabolism
- J: Translation, ribosomal structure and biogenesis
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ATP binding |
| kinase activity |
| nucleotide binding |
| phosphorylation |
| InterPro |
|---|
| Protein kinase domain |
| Protein kinase, ATP binding site |
| Protein kinase-like domain superfamily |
| Serine/threonine-protein kinase, active site |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0111352 | D-2-hydroxyglutaric aciduria 2 | |
| DOID:1324 | lung cancer | |
| DOID:3748 | esophagus squamous cell carcinoma | |
| DOID:3907 | lung squamous cell carcinoma | |
| DOID:3908 | lung non-small cell carcinoma | |
| DOID:4928 | intrahepatic cholangiocarcinoma | |
| DOID:5016 | hepatocellular clear cell carcinoma | |
| DOID:9119 | acute myeloid leukemia |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0001482 | Subcutaneous nodule |
| HP:0001510 | Growth delay |
| HP:0001638 | Cardiomyopathy |
| HP:0001903 | Anemia |
| HP:0001928 | Abnormality of coagulation |
| HP:0002015 | Dysphagia |
| HP:0002650 | Scoliosis |
| HP:0002653 | Bone pain |
| HP:0002664 | Neoplasm |
| HP:0002757 | Recurrent fractures |
| Disease ID | Disease Name |
|---|---|
| ORPHA:163634 |
|
| ORPHA:296 |
|
| OMIM:613657 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 101082315 | FELCA14044 | ||
| 101102843 | SHEEP07726 | ||
| 101151172 | GORGO09706 | ||
| 101166704 | ORYLA12598 | ||
| 101334037 | TURTR02273 | ||
| 101681001 | MUSPF08673 | ||
| 101708667 | HETGA05823 | ||
| 101811851 | FICAL13862 | ||
| 101925784 | MACFA38533 | ||
| 101934619 | CHRPI14387 |
