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Core 1 Galactosyltransferase A

Summary

Gene Symbol

C1GalTA

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

34215

KEGG Gene ID

dme:Dmel_CG9520

PubChem

34215

Alliance of Genome Resources

FB:FBgn0032078

Annotation

Keyword

3D-structure
Disulfide bond
Glycoprotein
Glycosyltransferase
Manganese
Metal-binding
Nucleotide-binding
Proteomics identification
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
E2QCQ7
Q7K237	Core 1 O-glycan T-synthase Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1 Core 1 beta1,3-galactosyltransferase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
muscle cell development	IMP	26896591
central nervous system morphogenesis	IMP	18985719
neuromuscular junction development	IMP	26896591
protein glycosylation	IDA	16128800 35504880
negative regulation of hematopoietic stem cell differentiation	IMP	25779703

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

biosynthetic process [inference]

cellular biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process

cellular metabolic process [inference]

cellular biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

macromolecule glycosylation [inference]

protein glycosylation

carbohydrate derivative metabolic process [inference]

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

cellular developmental process [inference]

cell development [inference]

muscle cell development

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell junction organization [inference]

synapse organization [inference]

neuromuscular junction development

developmental process [inference]

anatomical structure morphogenesis [inference]

central nervous system morphogenesis

anatomical structure development [inference]

cell development [inference]

muscle cell development

cellular developmental process [inference]

cell development [inference]

muscle cell development

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of hematopoietic stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of stem cell differentiation [inference]

regulation of hematopoietic stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of cellular process [inference]

regulation of cellular component biogenesis [inference]

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of filopodium assembly

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of hematopoietic stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of stem cell differentiation [inference]

regulation of hematopoietic stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of hematopoietic progenitor cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

negative regulation of stem cell differentiation [inference]

negative regulation of hematopoietic stem cell differentiation

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of filopodium assembly

regulation of plasma membrane bounded cell projection organization [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of filopodium assembly

Displaying 1 entry
GO Term	Evidence Code	PMID
membrane	IEA ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity	IBA IDA IMP	18824562 18985719 35504880
manganese ion binding	IDA	35504880
beta-1,3-galactosyltransferase activity	IDA	16128800
nucleotide binding
glycosyltransferase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity

hexosyltransferase activity [inference]

galactosyltransferase activity [inference]

beta-1,3-galactosyltransferase activity

glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity

catalytic activity, acting on a protein [inference]

catalytic activity, acting on a glycoprotein [inference]

glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

manganese ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1

Functional Category

M: Cell wall/membrane/envelope biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity

Displaying **all 2** entries
InterPro
C1GALT1/C1GALT1-specific chaperone 1
Fringe-like, glycosyltransferase domain

KEGG BRITE Database

Orthology

K00731

Name

glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase [EC:2.4.1.122]

References

11677243

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R05908	2.4.1.122	G57321FI	G00031MO

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
membrane	FB:FBrf0231198

Rhea

RHEA:15621

an N-acetyl-α-D-galactosaminyl derivative + UDP-α-D-galactose

a β-D-galactosyl-(1→3)-N-acetyl-α-D-galactosaminyl derivative + H⁺ + UDP

Enzyme

2.4.1.122

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060050	autoimmune disease of blood	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP008955
Gene Name: Core 1 Galactosyltransferase A

Ortholog

Displaying entries **1 - 10** of 57 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Homo sapiens	56913		HGNC:24337
Rattus norvegicus	65044		RGD:621105
Mus musculus	94192		MGI:2151071
Caenorhabditis elegans	176455		WB:WBGene00008019
Danio rerio	337131		ZFIN:ZDB-GENE-030131-9075
Danio rerio	555344		ZFIN:ZDB-GENE-060503-810
Danio rerio	557675		ZFIN:ZDB-GENE-061013-303
Drosophila pseudoobscura	4816132	7237_1:001ce1
Drosophila ananassae	6498499	7217_1:002e12
Drosophila yakuba	6527803	7245_1:000a71