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interferon gamma receptor 2

Summary

Gene Symbol

IFNGR2

Organism

Homo sapiens (human)

External Links

NCBI Gene

3460

PubChem

3460

Alliance of Genome Resources

HGNC:5440

Annotation

Keyword

3D-structure
Cell membrane
Cytoplasm
Cytoplasmic vesicle
Disease variant
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Golgi apparatus
Proteomics identification
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
E7EUY1
A8K881
P38484	Interferon gamma receptor accessory factor 1 Interferon gamma receptor beta-chain Interferon gamma transducer 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
microglial cell activation	IEA
cellular response to virus	NAS	15864272
type III interferon-mediated signaling pathway	IDA	20015550
cell surface receptor signaling pathway	TAS	9616207
response to virus	TAS	8124716

GO Hierarchy

biological process

immune system process [inference]

leukocyte activation [inference]

leukocyte activation involved in inflammatory response [inference]

microglial cell activation

myeloid leukocyte activation [inference]

macrophage activation [inference]

microglial cell activation

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

leukocyte activation involved in inflammatory response [inference]

microglial cell activation

myeloid leukocyte activation [inference]

macrophage activation [inference]

microglial cell activation

glial cell activation [inference]

microglial cell activation

signal transduction [inference]

cell surface receptor signaling pathway

cytokine-mediated signaling pathway

interferon-mediated signaling pathway [inference]

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

leukocyte activation involved in inflammatory response [inference]

microglial cell activation

myeloid leukocyte activation [inference]

macrophage activation [inference]

microglial cell activation

glial cell activation [inference]

microglial cell activation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of NMDA receptor activity [inference]

positive regulation of NMDA glutamate receptor activity

positive regulation of signaling receptor activity [inference]

positive regulation of NMDA glutamate receptor activity

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of NMDA glutamate receptor activity

regulation of NMDA receptor activity [inference]

positive regulation of NMDA glutamate receptor activity

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of NMDA glutamate receptor activity

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of NMDA glutamate receptor activity

regulation of monoatomic ion transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of NMDA glutamate receptor activity

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of NMDA glutamate receptor activity

positive regulation of transport [inference]

positive regulation of transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of NMDA glutamate receptor activity

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of NMDA glutamate receptor activity

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of NMDA glutamate receptor activity

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of NMDA glutamate receptor activity

positive regulation of transport [inference]

positive regulation of transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of NMDA glutamate receptor activity

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of NMDA glutamate receptor activity

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of NMDA glutamate receptor activity

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of NMDA receptor activity [inference]

positive regulation of NMDA glutamate receptor activity

positive regulation of signaling receptor activity [inference]

positive regulation of NMDA glutamate receptor activity

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

cytokine-mediated signaling pathway

interferon-mediated signaling pathway [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of NMDA receptor activity [inference]

positive regulation of NMDA glutamate receptor activity

positive regulation of signaling receptor activity [inference]

positive regulation of NMDA glutamate receptor activity

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of NMDA glutamate receptor activity

regulation of NMDA receptor activity [inference]

positive regulation of NMDA glutamate receptor activity

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of NMDA glutamate receptor activity

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of NMDA glutamate receptor activity

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of NMDA glutamate receptor activity

regulation of molecular function [inference]

regulation of signaling receptor activity [inference]

regulation of neurotransmitter receptor activity [inference]

regulation of NMDA receptor activity [inference]

positive regulation of NMDA glutamate receptor activity

positive regulation of signaling receptor activity [inference]

positive regulation of NMDA glutamate receptor activity

regulation of transporter activity [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of NMDA glutamate receptor activity

regulation of NMDA receptor activity [inference]

positive regulation of NMDA glutamate receptor activity

positive regulation of transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of NMDA glutamate receptor activity

positive regulation of molecular function [inference]

positive regulation of transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of NMDA glutamate receptor activity

positive regulation of signaling receptor activity [inference]

positive regulation of NMDA glutamate receptor activity

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cytoplasmic vesicle membrane	IEA
endoplasmic reticulum membrane	IEA
plasma membrane	HDA IBA IDA TAS	16780588 20015550
Golgi membrane	IEA
endoplasmic reticulum	HDA	16780588

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	32296183
cytokine receptor activity	IBA
type II interferon receptor activity	IDA	20015550

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity

interferon receptor activity [inference]

type II interferon receptor activity

immune receptor activity [inference]

cytokine receptor activity

interferon receptor activity [inference]

type II interferon receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Interferon gamma receptor 2

Functional Category

E: Amino acid transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
InterPro
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin-like fold
Interferon/interleukin receptor domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0111995	immunodeficiency 28	Alliance of Genome Resources
DOID:9744	type 1 diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 44 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	15980		MGI:107654	MOUSE17671
Rattus norvegicus	360697		RGD:1307532	RATNO04324
Xenopus tropicalis	448345		Xenbase:XB-GENE-5780408
Pan troglodytes	470077	9598_0:0052d7		PANTR25580
Canis lupus familiaris	487739			CANLF12835
Danio rerio	562820		ZFIN:ZDB-GENE-030131-5999
Macaca mulatta	699489			MACMU32195
Ornithorhynchus anatinus	100083438			ORNAN09076
Sus scrofa	100126864			PIGXX06071
Papio anubis	100137246			PAPAN30540