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solute carrier family 35 member B2

Summary

Gene Symbol

SLC35B2

Aliases

UGTrel4

Organism

Homo sapiens (human)

External Links

NCBI Gene

347734

GGDB ID

gg179

HGNC

16872

mRNA

NM_178148

map

6p12.1-p11.2

Protein

NP_835361

OMIM

610788

KEGG Gene ID

hsa:347734

PubChem

347734

Alliance of Genome Resources

HGNC:16872

Annotation

Keyword

Alternative splicing
Antiport
Golgi apparatus
Leukodystrophy
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8TB61	PAPS transporter 1 Putative MAPK-activating protein PM15 Putative NF-kappa-B-activating protein 48 Solute carrier family 35 member B2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
transmembrane transport	IBA
chondroitin sulfate biosynthetic process	IMP	35325049
3'-phosphoadenosine 5'-phosphosulfate transport	IBA IDA	12716889
positive regulation of canonical NF-kappaB signal transduction	HMP	12761501
5'-adenylyl sulfate transmembrane transport

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

chondroitin sulfate metabolic process [inference]

chondroitin sulfate biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

chondroitin sulfate biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

chondroitin sulfate metabolic process [inference]

chondroitin sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

chondroitin sulfate biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

chondroitin sulfate biosynthetic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

chondroitin sulfate metabolic process [inference]

chondroitin sulfate biosynthetic process

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

chondroitin sulfate metabolic process [inference]

chondroitin sulfate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

chondroitin sulfate metabolic process [inference]

chondroitin sulfate biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

chondroitin sulfate metabolic process [inference]

chondroitin sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

chondroitin sulfate biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

chondroitin sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

chondroitin sulfate biosynthetic process

transmembrane transport

purine-containing compound transmembrane transport [inference]

nucleotide transmembrane transport [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

transmembrane transport

purine-containing compound transmembrane transport [inference]

nucleotide transmembrane transport [inference]

organic substance transport [inference]

organic anion transport [inference]

3'-phosphoadenosine 5'-phosphosulfate transport

3'-phospho-5'-adenylyl sulfate transmembrane transport

5'-adenylyl sulfate transmembrane transport

organophosphate ester transport [inference]

nucleotide transport [inference]

purine nucleotide transport [inference]

purine ribonucleotide transport [inference]

3'-phosphoadenosine 5'-phosphosulfate transport

3'-phospho-5'-adenylyl sulfate transmembrane transport

5'-adenylyl sulfate transmembrane transport

adenine nucleotide transport [inference]

3'-phosphoadenosine 5'-phosphosulfate transport

3'-phospho-5'-adenylyl sulfate transmembrane transport

5'-adenylyl sulfate transmembrane transport

nucleotide transmembrane transport [inference]

nucleobase-containing compound transport [inference]

nucleotide transport [inference]

purine nucleotide transport [inference]

purine ribonucleotide transport [inference]

3'-phosphoadenosine 5'-phosphosulfate transport

3'-phospho-5'-adenylyl sulfate transmembrane transport

5'-adenylyl sulfate transmembrane transport

adenine nucleotide transport [inference]

3'-phosphoadenosine 5'-phosphosulfate transport

3'-phospho-5'-adenylyl sulfate transmembrane transport

5'-adenylyl sulfate transmembrane transport

nucleotide transmembrane transport [inference]

purine-containing compound transmembrane transport [inference]

carbohydrate derivative transport [inference]

purine ribonucleotide transport [inference]

3'-phosphoadenosine 5'-phosphosulfate transport

3'-phospho-5'-adenylyl sulfate transmembrane transport

5'-adenylyl sulfate transmembrane transport

nitrogen compound transport [inference]

nucleobase-containing compound transport [inference]

nucleotide transport [inference]

purine nucleotide transport [inference]

purine ribonucleotide transport [inference]

3'-phosphoadenosine 5'-phosphosulfate transport

3'-phospho-5'-adenylyl sulfate transmembrane transport

5'-adenylyl sulfate transmembrane transport

adenine nucleotide transport [inference]

3'-phosphoadenosine 5'-phosphosulfate transport

3'-phospho-5'-adenylyl sulfate transmembrane transport

5'-adenylyl sulfate transmembrane transport

nucleotide transmembrane transport [inference]

purine-containing compound transmembrane transport [inference]

sulfur compound transport [inference]

3'-phosphoadenosine 5'-phosphosulfate transport

3'-phospho-5'-adenylyl sulfate transmembrane transport

5'-adenylyl sulfate transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	IBA
membrane	IDA NAS	12716889
Golgi apparatus	IDA	12716889 35325049
Golgi membrane	IBA IDA TAS	12716889

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying **all 3** entries
GO Term	Evidence Code	PMID
antiporter activity	IEA
3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity	IBA IDA TAS	12716889
protein binding	IPI	32296183

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

organic anion transmembrane transporter activity [inference]

3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity

organophosphate ester transmembrane transporter activity [inference]

nucleotide transmembrane transporter activity [inference]

purine nucleotide transmembrane transporter activity [inference]

adenine nucleotide transmembrane transporter activity [inference]

3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity

purine ribonucleotide transmembrane transporter activity [inference]

3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity

nucleobase-containing compound transmembrane transporter activity [inference]

nucleotide transmembrane transporter activity [inference]

purine nucleotide transmembrane transporter activity [inference]

adenine nucleotide transmembrane transporter activity [inference]

3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity

purine ribonucleotide transmembrane transporter activity [inference]

3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

antiporter activity

carbohydrate derivative transmembrane transporter activity [inference]

purine ribonucleotide transmembrane transporter activity [inference]

3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity

sulfur compound transmembrane transporter activity [inference]

3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000157593

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg179

Gene Symbol

SLC35B2

Orthologous Gene

Displaying **all 4** entries
Species	Protein	mRNA
Rattus norvegicus	AAI00648	ABC100647
Drosophila melanogaster	NP_524389	NM_079665
Caenorhabditis elegans	NP_741546	NM_171464
Mus musculus	AAH25875	BC025875

KEGG BRITE Database

Orthology

K15276

Name

solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2

References

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0050746	mantle cell lymphoma	DisGeNET
DOID:0050747	obsolete lymphoplasmacytic lymphoma	DisGeNET
DOID:0050873	follicular lymphoma	DisGeNET
DOID:0060058	lymphoma	DisGeNET DisGeNET
DOID:0060060	non-Hodgkin lymphoma	DisGeNET
DOID:0060707	lymphoproliferative syndrome 1	DisGeNET
DOID:0060708	lymphoproliferative syndrome 2	DisGeNET
DOID:0060901	lymphoplasmacytic lymphoma	DisGeNET
DOID:0070324	systemic Epstein-Barr virus positive T-cell lymphoma of childhood	DisGeNET
DOID:0070403	hypomyelinating leukodystrophy 26	Alliance of Genome Resources

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000162	Glossoptosis
HP:0000175	Cleft palate
HP:0000201	Pierre-Robin sequence
HP:0000278	Retrognathia
HP:0000666	Horizontal nystagmus
HP:0001181	Adducted thumb
HP:0001263	Global developmental delay
HP:0001272	Cerebellar atrophy
HP:0001344	Absent speech

Displaying 1 entry
Disease ID	Disease Name
OMIM:620269	leukodystrophy, hypomyelinating, 26, with chondrodysplasia

PubChem Disease

MedGen Diseases

Leukodystrophy, hypomyelinating, 26, with chondrodysplasia

OMIM Phenotypes

LEUKODYSTROPHY, HYPOMYELINATING, 26, WITH CHONDRODYSPLASIA; HLD26

KEGG Diseases

Hypomyelinating leukodystrophy

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	178980	WB:WBGene00004206
Drosophila melanogaster	42115	FB:FBgn0038524
Ciona intestinalis	100177698		CIOIN02556
Callorhinchus milii	103181597		CALMI23166
Latimeria chalumnae	102358440		LATCH06519
Danio rerio	402931	ZFIN:ZDB-GENE-050213-1	DANRE19860
Astyanax mexicanus	103047832		ASTMX01281
Ictalurus punctatus	108258105		ICTPU20519
Electrophorus electricus	113580865		ELEEL03481
Salmo salar	106571220		SALSA75858

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements