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Guidelines

MIRAGE

insulin like growth factor binding protein 2

Summary

Gene Symbol

IGFBP2

Organism

Homo sapiens (human)

External Links

NCBI Gene

3485

PubChem

3485

Alliance of Genome Resources

HGNC:5471

Annotation

Keyword

3D-structure
Direct protein sequencing
Disulfide bond
Glycoprotein
Growth factor binding
Growth regulation
Proteomics identification
Reference proteome
Secreted
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
C9JMY1
P18065

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
osteoblast differentiation	IDA	26773517
female pregnancy	IEA
response to nutrient	IEA
response to xenobiotic stimulus	IEA
response to mechanical stimulus	IEA

GO Hierarchy

biological process

cellular process [inference]

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus

reproductive process [inference]

multi-organism reproductive process [inference]

female pregnancy

multicellular organismal process [inference]

multi-multicellular organism process [inference]

female pregnancy

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

response to stimulus [inference]

response to external stimulus [inference]

response to mechanical stimulus

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient

response to abiotic stimulus [inference]

response to mechanical stimulus

response to endogenous stimulus [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to organic cyclic compound [inference]

response to estradiol

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to lipid [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

cellular response to organic substance [inference]

cellular response to hormone stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus

response to oxygen-containing compound [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

regulation of activated T cell proliferation [inference]

positive regulation of activated T cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

regulation of activated T cell proliferation [inference]

positive regulation of activated T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of insulin-like growth factor receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of insulin-like growth factor receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of insulin-like growth factor receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

regulation of leukocyte proliferation [inference]

regulation of mononuclear cell proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

regulation of lymphocyte proliferation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

regulation of activated T cell proliferation [inference]

positive regulation of activated T cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

regulation of activated T cell proliferation [inference]

positive regulation of activated T cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

regulation of activated T cell proliferation [inference]

positive regulation of activated T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

regulation of activated T cell proliferation [inference]

positive regulation of activated T cell proliferation

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

regulation of activated T cell proliferation [inference]

positive regulation of activated T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

positive regulation of T cell activation [inference]

positive regulation of T cell proliferation [inference]

positive regulation of activated T cell proliferation

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
extracellular region	ISS
extracellular region	TAS
extracellular space	IDA	15694994 22869525
extracellular space	IBA
apical plasma membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane region [inference]

apical plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
protein phosphatase inhibitor activity	IDA	22869525
signaling receptor binding	TAS	24431302
protein binding	IPI	19095771
signaling receptor inhibitor activity	IDA	22869525
insulin-like growth factor I binding	IDA	19081843

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding

growth factor binding [inference]

insulin-like growth factor binding [inference]

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

phosphatase inhibitor activity [inference]

protein phosphatase inhibitor activity

phosphatase regulator activity [inference]

phosphatase inhibitor activity [inference]

protein phosphatase inhibitor activity

protein phosphatase regulator activity [inference]

protein phosphatase inhibitor activity

signaling receptor regulator activity [inference]

signaling receptor inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

phosphatase inhibitor activity [inference]

protein phosphatase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Insulin-like growth factor-binding protein 2-A

Functional Category

G: Carbohydrate transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
growth factor binding
insulin-like growth factor I binding
insulin-like growth factor II binding
insulin-like growth factor binding
regulation of insulin-like growth factor receptor signaling pathway

Displaying **all 6** entries
InterPro
Growth factor receptor cysteine-rich domain superfamily
Insulin-like growth factor binding protein 2
Insulin-like growth factor-binding protein family 1-6, chordata
Insulin-like growth factor-binding protein, IGFBP
Thyroglobulin type-1 superfamily
Thyroglobulin type-1

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:9970	obesity	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 48 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	3485	Xenbase:XB-GENE-487299
Mus musculus	16008		MOUSE30434
Rattus norvegicus	25662		RATNO42944
Bos taurus	282260		BOVIN24722
Sus scrofa	397064		PIGXX09959
Pan troglodytes	460116		PANTR29737
Macaca mulatta	696214		MACMU07008
Danio rerio	794176		DANRE39255
Equus caballus	100034061		HORSE37637
Salmo salar	100136519		SALSA52775

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Last updated: August 4, 2025