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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
hyperpolarization activated cyclic nucleotide gated potassium channel 1
Summary
- Gene Symbol
-
- HCN1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Cell membrane
- Disease variant
- Epilepsy
- Glycoprotein
- Ligand-gated ion channel
- Potassium channel
- Reference proteome
- Sodium channel
- Transmembrane helix
- Voltage-gated channel
- cAMP-binding
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| regulation of postsynaptic membrane potential | ||
| cellular response to cAMP | ||
| neuronal action potential | ||
| apical protein localization | ||
| potassium ion transmembrane transport |
GO Hierarchy
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| voltage-gated sodium channel activity | ||
| identical protein binding | ||
| potassium channel activity | ||
| voltage-gated monoatomic cation channel activity |
GO Hierarchy
molecular function
transporter activity [inference]
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- cyclic nucleotide-gated cation channel
- Functional Category
-
- E: Amino acid transport and metabolism
- K: Transcription
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| monoatomic ion channel activity |
| monoatomic ion transport |
| InterPro |
|---|
| Cyclic nucleotide-binding domain superfamily |
| Cyclic nucleotide-binding domain |
| Ion transport domain |
| RmlC-like jelly roll fold |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080429 | developmental and epileptic encephalopathy 24 | |
| DOID:0090131 | complex cortical dysplasia with other brain malformations | |
| DOID:0111296 | generalized epilepsy with febrile seizures plus 10 | |
| DOID:11832 | visual epilepsy | |
| DOID:13884 | sick sinus syndrome | |
| DOID:1824 | status epilepticus | |
| DOID:1825 | childhood absence epilepsy | |
| DOID:2030 | anxiety disorder | |
| DOID:3324 | mood disorder | |
| DOID:3328 | temporal lobe epilepsy |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 15165 | MGI:1096392 | MOUSE11738 | ||
| 36589 | FB:FBgn0263397 | |||
| 84390 | RGD:620688 | RATNO24523 | ||
| 471552 | 9598_0:001865 | PANTR35604 | ||
| 538255 | BOVIN15960 | |||
| 612434 | CANLF14964 | |||
| 704286 | MACMU37890 | |||
| 100008732 | RABIT01954 | |||
| 100064345 | HORSE20169 | |||
| 100334297 | DANRE21601 |
