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Leukocyte-antigen-related-like

Summary

Gene Symbol

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

35259

PubChem

35259

Alliance of Genome Resources

FB:FBgn0000464

Annotation

Keyword

3D-structure
Cell adhesion
Disulfide bond
Glycoprotein
Heparin-binding
Immunoglobulin domain
Neurogenesis
Phosphoprotein
Protein phosphatase
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix

Proteins

Displaying **all 7** entries
UniProt	Protein Name
A8DZ18
M9PDR3
M9PG93
M9PD76
M9PDF7
M9NCY3
P16621	Protein-tyrosine-phosphate phosphohydrolase dLAR

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
R7 cell development	IMP	16864797 18400161 19889974
regulation of axon extension involved in axon guidance	IMP	19766621
positive regulation of plasma membrane bounded cell projection assembly	IMP	26903538
synaptic membrane adhesion	IBA
signal transduction	IBA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

axon target recognition

cell adhesion

cell-cell adhesion [inference]

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

synaptic membrane adhesion

signal transduction

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension

cellular process involved in reproduction in multicellular organism [inference]

germ cell development [inference]

oogenesis

follicle cell of egg chamber migration [inference]

centripetally migrating follicle cell migration

cellular developmental process [inference]

cell development [inference]

germ cell development [inference]

oogenesis

neuron development [inference]

photoreceptor cell development [inference]

eye photoreceptor cell development [inference]

compound eye photoreceptor development [inference]

R7 cell development

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

epithelial cell migration [inference]

follicle cell of egg chamber migration [inference]

centripetally migrating follicle cell migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

synapse assembly [inference]

synaptic assembly at neuromuscular junction

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly [inference]

synaptic assembly at neuromuscular junction

synapse organization [inference]

synapse assembly [inference]

synaptic assembly at neuromuscular junction

neuromuscular junction development [inference]

synaptic assembly at neuromuscular junction

reproductive process [inference]

developmental process involved in reproduction [inference]

germ cell development [inference]

oogenesis

spermatogenesis

cellular process involved in reproduction in multicellular organism [inference]

germ cell development [inference]

oogenesis

follicle cell of egg chamber migration [inference]

centripetally migrating follicle cell migration

multicellular organismal reproductive process [inference]

gamete generation [inference]

female gamete generation [inference]

oogenesis

male gamete generation [inference]

spermatogenesis

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

hematopoietic stem cell homeostasis

developmental process [inference]

developmental process involved in reproduction [inference]

germ cell development [inference]

oogenesis

spermatogenesis

anatomical structure morphogenesis [inference]

cell morphogenesis [inference]

cell morphogenesis involved in neuron differentiation [inference]

photoreceptor cell morphogenesis

anatomical structure development [inference]

cell development [inference]

germ cell development [inference]

oogenesis

neuron development [inference]

photoreceptor cell development [inference]

eye photoreceptor cell development [inference]

compound eye photoreceptor development [inference]

R7 cell development

system development [inference]

nervous system development

cellular developmental process [inference]

cell development [inference]

germ cell development [inference]

oogenesis

neuron development [inference]

photoreceptor cell development [inference]

eye photoreceptor cell development [inference]

compound eye photoreceptor development [inference]

R7 cell development

growth [inference]

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension

developmental growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension

synaptic assembly at neuromuscular junction

developmental growth involved in morphogenesis [inference]

neuron projection extension [inference]

axon extension

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

hematopoietic stem cell homeostasis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

regulation of insulin receptor signaling pathway [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

regulation of growth [inference]

regulation of cell growth [inference]

regulation of extent of cell growth [inference]

regulation of axon extension [inference]

regulation of axon extension involved in axon guidance

regulation of developmental growth [inference]

regulation of axon extension [inference]

regulation of axon extension involved in axon guidance

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of plasma membrane bounded cell projection assembly

positive regulation of filopodium assembly

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly

positive regulation of filopodium assembly

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of homophilic cell adhesion

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

regulation of insulin receptor signaling pathway [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of cellular response to insulin stimulus [inference]

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of developmental process [inference]

regulation of developmental growth [inference]

regulation of axon extension [inference]

regulation of axon extension involved in axon guidance

regulation of cellular process [inference]

signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

regulation of insulin receptor signaling pathway [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

regulation of cell adhesion [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of homophilic cell adhesion

regulation of cell-cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of homophilic cell adhesion

regulation of homophilic cell adhesion [inference]

negative regulation of homophilic cell adhesion

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of plasma membrane bounded cell projection assembly

positive regulation of filopodium assembly

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of filopodium assembly [inference]

positive regulation of filopodium assembly

positive regulation of plasma membrane bounded cell projection assembly

positive regulation of filopodium assembly

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of plasma membrane bounded cell projection assembly

positive regulation of filopodium assembly

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly

positive regulation of filopodium assembly

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of homophilic cell adhesion

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of cellular component organization [inference]

regulation of cell growth [inference]

regulation of extent of cell growth [inference]

regulation of axon extension [inference]

regulation of axon extension involved in axon guidance

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly

positive regulation of filopodium assembly

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of filopodium assembly [inference]

positive regulation of filopodium assembly

positive regulation of plasma membrane bounded cell projection assembly

positive regulation of filopodium assembly

regulation of plasma membrane bounded cell projection organization [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of filopodium assembly [inference]

positive regulation of filopodium assembly

positive regulation of plasma membrane bounded cell projection assembly

positive regulation of filopodium assembly

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly

positive regulation of filopodium assembly

regulation of cellular response to insulin stimulus [inference]

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

Displaying **all 5** entries
GO Term	Evidence Code	PMID
basal plasma membrane	IDA	26903538
axon	IDA	15043815 18237413
cell leading edge	IDA	28292425
focal adhesion	IDA	21430143
cell surface	IDA	15043815

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell surface

membrane [inference]

plasma membrane region [inference]

basal plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

cell leading edge

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

Displaying **all 5** entries
GO Term	Evidence Code	PMID
SAM domain binding	IPI	21084592 21430143
protein tyrosine phosphatase activity	IBA IDA IEA	21931847
insulin receptor binding	IPI	31784462
heparin binding
transmembrane receptor protein tyrosine phosphatase activity	IDA	2554325

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

transmembrane receptor protein tyrosine phosphatase activity

transmembrane receptor protein phosphatase activity [inference]

transmembrane receptor protein tyrosine phosphatase activity

catalytic activity, acting on a protein [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

transmembrane receptor protein tyrosine phosphatase activity

transmembrane receptor protein phosphatase activity [inference]

transmembrane receptor protein tyrosine phosphatase activity

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

insulin receptor binding

protein domain specific binding [inference]

SAM domain binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein phosphatase activity [inference]

transmembrane receptor protein tyrosine phosphatase activity

Gene Ontology information from NCBI Gene and UniProt.

Alliance of Genome Resources

Expression

Displaying **all 7** entries
Location	References
cell leading edge	PMID:28292425
cell surface	PMID:15043815
membrane	FB:FBrf0231198
basal plasma membrane	PMID:26903538
focal adhesion	PMID:21430143
axon	PMID:15043815 PMID:18237413
plasma membrane	PMID:22378638

Disease

Disease Ontology

Displaying **all 8** entries
DO ID	Disease Name	Source
DOID:0050425	restless legs syndrome	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:14227	azoospermia	Alliance of Genome Resources
DOID:2018	hyperinsulinism	Alliance of Genome Resources
DOID:3393	coronary artery disease	Alliance of Genome Resources
DOID:9351	diabetes mellitus	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements