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MIRAGE
adenine phosphoribosyltransferase
Summary
- Gene Symbol
-
- APRT
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Alternative splicing
- Cytoplasm
- Direct protein sequencing
- Disease variant
- Glycosyltransferase
- Phosphoprotein
- Purine salvage
- Reference proteome
- Proteins
| UniProt | Protein Name |
|---|---|
| P07741 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| purine ribonucleoside salvage | ||
| adenine salvage | ||
| grooming behavior | ||
| GMP salvage | ||
| IMP salvage |
GO Hierarchy
biological process
metabolic process [inference]
nitrogen compound metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
nucleobase-containing compound biosynthetic process [inference]
nucleobase-containing small molecule metabolic process [inference]
cellular nitrogen compound biosynthetic process [inference]
organonitrogen compound metabolic process [inference]
biosynthetic process [inference]
cellular biosynthetic process [inference]
heterocycle biosynthetic process [inference]
aromatic compound biosynthetic process [inference]
cellular nitrogen compound biosynthetic process [inference]
organic substance biosynthetic process [inference]
cellular metabolic process [inference]
cellular aromatic compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
nucleobase-containing compound biosynthetic process [inference]
nucleobase-containing small molecule metabolic process [inference]
aromatic compound biosynthetic process [inference]
phosphorus metabolic process [inference]
phosphate-containing compound metabolic process [inference]
organophosphate metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
nucleobase-containing compound biosynthetic process [inference]
nucleobase-containing small molecule metabolic process [inference]
cellular nitrogen compound biosynthetic process [inference]
cellular biosynthetic process [inference]
heterocycle biosynthetic process [inference]
aromatic compound biosynthetic process [inference]
cellular nitrogen compound biosynthetic process [inference]
heterocycle metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
nucleobase-containing compound biosynthetic process [inference]
nucleobase-containing small molecule metabolic process [inference]
heterocycle biosynthetic process [inference]
primary metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
nucleobase-containing compound biosynthetic process [inference]
nucleobase-containing small molecule metabolic process [inference]
small molecule metabolic process [inference]
organic substance metabolic process [inference]
organophosphate metabolic process [inference]
carbohydrate derivative metabolic process [inference]
organic cyclic compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
nucleobase-containing compound biosynthetic process [inference]
nucleobase-containing small molecule metabolic process [inference]
purine-containing compound metabolic process [inference]
organic cyclic compound biosynthetic process [inference]
organonitrogen compound metabolic process [inference]
organic substance biosynthetic process [inference]
cellular process [inference]
cellular metabolic process [inference]
cellular aromatic compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
nucleobase-containing compound biosynthetic process [inference]
nucleobase-containing small molecule metabolic process [inference]
aromatic compound biosynthetic process [inference]
phosphorus metabolic process [inference]
phosphate-containing compound metabolic process [inference]
organophosphate metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
nucleobase-containing compound biosynthetic process [inference]
nucleobase-containing small molecule metabolic process [inference]
cellular nitrogen compound biosynthetic process [inference]
cellular biosynthetic process [inference]
heterocycle biosynthetic process [inference]
aromatic compound biosynthetic process [inference]
cellular nitrogen compound biosynthetic process [inference]
heterocycle metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
nucleobase-containing compound biosynthetic process [inference]
nucleobase-containing small molecule metabolic process [inference]
heterocycle biosynthetic process [inference]
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| adenine binding | ||
| adenine phosphoribosyltransferase activity | ||
| adenine phosphoribosyltransferase activity | ||
| protein binding | ||
| AMP binding |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- adenine_phosphoribosyltransferase
- Functional Category
-
- E: Amino acid transport and metabolism
- G: Carbohydrate transport and metabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| AMP salvage |
| adenine phosphoribosyltransferase activity |
| adenine salvage |
| purine ribonucleoside salvage |
| transferase activity |
| InterPro |
|---|
| Adenine phosphoribosyl transferase |
| Phosphoribosyltransferase domain |
| Phosphoribosyltransferase-like |
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060350 | adenine phosphoribosyltransferase deficiency |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0000010 | Recurrent urinary tract infections |
| HP:0000016 | Urinary retention |
| HP:0000019 | Urinary hesitancy |
| HP:0000083 | Renal insufficiency |
| HP:0000093 | Proteinuria |
| HP:0000787 | Nephrolithiasis |
| HP:0000790 | Hematuria |
| HP:0000791 | Uric acid nephrolithiasis |
| HP:0000822 | Hypertension |
| Disease ID | Disease Name |
|---|---|
| OMIM:614723 |
|
| ORPHA:976 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 353 | Xenbase:XB-GENE-5848953 | ||
| 11821 | Xenbase:XB-GENE-5848953 | MOUSE59078 | |
| 48224 | Xenbase:XB-GENE-5848953 | ||
| 172232 | Xenbase:XB-GENE-5848953 | ||
| 292072 | Xenbase:XB-GENE-5848953 | RATNO14800 | |
| 393641 | DANRE40714 | ||
| 479615 | CANLF15858 | ||
| 736305 | PANTR13072 | ||
| 852051 | Xenbase:XB-GENE-5848953 | ||
| 854986 | Xenbase:XB-GENE-5848953 |
