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Integrin betanu subunit

Summary

Gene Symbol

Itgbn

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

35368

PubChem

35368

Alliance of Genome Resources

FB:FBgn0010395

Annotation

Keyword

Cell adhesion
Disulfide bond
Glycoprotein
Integrin
Phagocytosis
Proteomics identification
Receptor
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q27591
A0A0S0WGT1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
cell-matrix adhesion	IBA TAS	10908592
cell-cell adhesion	IBA
cell adhesion mediated by integrin	IBA ISS
apoptotic cell clearance	IMP	23426364
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	TAS	10908592

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

encapsulation of foreign target [inference]

melanotic encapsulation of foreign target

immune response [inference]

innate immune response [inference]

melanization defense response [inference]

melanotic encapsulation of foreign target

metabolic process [inference]

secondary metabolic process [inference]

melanin metabolic process [inference]

melanization defense response [inference]

melanotic encapsulation of foreign target

pigment metabolic process [inference]

melanin metabolic process [inference]

melanization defense response [inference]

melanotic encapsulation of foreign target

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

melanin metabolic process [inference]

melanization defense response [inference]

melanotic encapsulation of foreign target

organic substance metabolic process [inference]

organic cyclic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

melanin metabolic process [inference]

melanization defense response [inference]

melanotic encapsulation of foreign target

organic hydroxy compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

melanin metabolic process [inference]

melanization defense response [inference]

melanotic encapsulation of foreign target

cellular process [inference]

cell adhesion [inference]

cell-substrate adhesion [inference]

cell-matrix adhesion

cell adhesion mediated by integrin

cell-cell adhesion

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis

apoptotic cell clearance

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

melanin metabolic process [inference]

melanization defense response [inference]

melanotic encapsulation of foreign target

cell motility [inference]

cell migration

homeostatic process [inference]

cellular homeostasis [inference]

muscle cell cellular homeostasis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

melanization defense response [inference]

melanotic encapsulation of foreign target

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response [inference]

melanization defense response [inference]

melanotic encapsulation of foreign target

immune response [inference]

innate immune response [inference]

melanization defense response [inference]

melanotic encapsulation of foreign target

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

melanization defense response [inference]

melanotic encapsulation of foreign target

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

melanization defense response [inference]

melanotic encapsulation of foreign target

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis

apoptotic cell clearance

import into cell [inference]

endocytosis [inference]

phagocytosis

apoptotic cell clearance

biological regulation [inference]

regulation of biological process [inference]

regulation of growth [inference]

negative regulation of growth [inference]

negative regulation of developmental growth [inference]

negative regulation of synaptic assembly at neuromuscular junction

regulation of developmental growth [inference]

regulation of synaptic assembly at neuromuscular junction [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of developmental growth [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of biological process [inference]

negative regulation of growth [inference]

negative regulation of developmental growth [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of cell junction assembly [inference]

negative regulation of synapse assembly [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of synapse organization [inference]

negative regulation of synapse assembly [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of neuromuscular junction development [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of developmental process [inference]

negative regulation of developmental growth [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of nervous system development [inference]

negative regulation of synapse assembly [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of synapse assembly [inference]

negative regulation of synaptic assembly at neuromuscular junction

regulation of developmental process [inference]

regulation of developmental growth [inference]

regulation of synaptic assembly at neuromuscular junction [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of developmental growth [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of developmental process [inference]

negative regulation of developmental growth [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of nervous system development [inference]

negative regulation of synapse assembly [inference]

negative regulation of synaptic assembly at neuromuscular junction

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

negative regulation of nervous system development [inference]

negative regulation of synapse assembly [inference]

negative regulation of synaptic assembly at neuromuscular junction

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of synaptic assembly at neuromuscular junction [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of synapse assembly [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of cell junction assembly [inference]

negative regulation of synapse assembly [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of cell junction assembly [inference]

negative regulation of synapse assembly [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of synapse organization [inference]

negative regulation of synapse assembly [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of neuromuscular junction development [inference]

negative regulation of synaptic assembly at neuromuscular junction

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

regulation of synaptic assembly at neuromuscular junction [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of synapse assembly [inference]

negative regulation of synaptic assembly at neuromuscular junction

regulation of neuromuscular junction development [inference]

regulation of synaptic assembly at neuromuscular junction [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of neuromuscular junction development [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of synapse organization [inference]

negative regulation of synapse assembly [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of neuromuscular junction development [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of cellular component organization [inference]

negative regulation of cell junction assembly [inference]

negative regulation of synapse assembly [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of synapse organization [inference]

negative regulation of synapse assembly [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of neuromuscular junction development [inference]

negative regulation of synaptic assembly at neuromuscular junction

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of synaptic assembly at neuromuscular junction [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of synapse assembly [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of cell junction assembly [inference]

negative regulation of synapse assembly [inference]

negative regulation of synaptic assembly at neuromuscular junction

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of synapse assembly [inference]

negative regulation of synaptic assembly at neuromuscular junction

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

negative regulation of nervous system development [inference]

negative regulation of synapse assembly [inference]

negative regulation of synaptic assembly at neuromuscular junction

Displaying **all 4** entries
GO Term	Evidence Code	PMID
membrane	IDA	23426364
focal adhesion	IBA
integrin complex	IBA IDA ISS NAS TAS	10908592 10936444 14519396 23426364 8076521
cell surface	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex

protein complex involved in cell adhesion [inference]

integrin complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex

cellular anatomical entity [inference]

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

Displaying **all 2** entries
GO Term	Evidence Code	PMID
integrin binding	IBA
protein heterodimerization activity	IPI	23426364

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

integrin binding

protein dimerization activity [inference]

protein heterodimerization activity

cell adhesion molecule binding [inference]

integrin binding

protein-containing complex binding [inference]

integrin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Integrin beta

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
cell adhesion mediated by integrin
cell migration
cell-matrix adhesion
integrin binding
integrin-mediated signaling pathway

Displaying **all 7** entries
InterPro
Integrin beta subunit, VWA domain
Integrin beta subunit, cytoplasmic domain
Integrin beta subunit, tail
Integrin beta subunit
Integrin beta tail domain superfamily
Integrin domain superfamily
von Willebrand factor A-like domain superfamily

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
membrane	PMID:23426364
integrin complex	PMID:23426364

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0060733	junctional epidermolysis bullosa with pyloric atresia	Alliance of Genome Resources
DOID:10908	hydrocephalus	Alliance of Genome Resources
DOID:2921	glomerulonephritis	Alliance of Genome Resources
DOID:3209	junctional epidermolysis bullosa	Alliance of Genome Resources
DOID:5844	myocardial infarction	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 45 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Homo sapiens	3691		HGNC:6158
Homo sapiens	3696		HGNC:6163
Homo sapiens	9358		HGNC:6164
Mus musculus	16415		MGI:1277979
Rattus norvegicus	24511		RGD:2927
Caenorhabditis elegans	182254		WB:WBGene00015472
Danio rerio	797491		ZFIN:ZDB-GENE-100728-2
Drosophila pseudoobscura	4818199	7237_0:0027e2
Drosophila ananassae	6503730	7217_1:002b7c
Drosophila yakuba	6529261	7245_1:00197f

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements