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kallikrein related peptidase 3

Summary

Gene Symbol

KLK3

Organism

Homo sapiens (human)

External Links

NCBI Gene

354

PubChem

354

Alliance of Genome Resources

HGNC:6364

Annotation

Keyword

3D-structure
Alternative splicing
Direct protein sequencing
Disulfide bond
Glycoprotein
Reference proteome
Secreted
Serine protease
Signal
Zymogen

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P07288	Gamma-seminoprotein Kallikrein-3 P-30 antigen Semenogelase
Q546G3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
proteolysis	IMP	15563730
negative regulation of angiogenesis	NAS	10675891
protein maturation	IBA
positive regulation of antibacterial peptide production	IDA	18714013

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

primary metabolic process [inference]

protein metabolic process [inference]

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of immune effector process [inference]

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of immune response [inference]

regulation of humoral immune response [inference]

regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

positive regulation of response to external stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

negative regulation of biological process [inference]

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of response to biotic stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

regulation of defense response to bacterium [inference]

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

regulation of response to external stimulus [inference]

regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of response to external stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

regulation of defense response to bacterium [inference]

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

positive regulation of response to external stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of immune response [inference]

regulation of humoral immune response [inference]

regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

regulation of defense response to bacterium [inference]

positive regulation of defense response to bacterium [inference]

positive regulation of antibacterial peptide production

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production [inference]

positive regulation of antibacterial peptide production

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
secretory granule	IBA
protein-containing complex	IDA	8665956
extracellular region	NAS TAS	14718574
extracellular space	IBA IDA	8665956
nucleus	HDA	21630459

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	1725227 8665956
endopeptidase activity	IDA	18714013
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	IMP	8665956
serine-type peptidase activity	TAS	2470553
serine-type endopeptidase activity	IBA IMP TAS	15563730

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

serine hydrolase activity [inference]

serine-type peptidase activity

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

serine protease

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
proteolysis
serine-type endopeptidase activity

Displaying **all 5** entries
InterPro
Peptidase S1, PA clan, chymotrypsin-like fold
Peptidase S1, PA clan
Peptidase S1A, chymotrypsin family
Serine proteases, trypsin domain
Serine proteases, trypsin family, histidine active site

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:1612	breast cancer	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 32 in total

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Species	Gene ID	Alliance of Genome Resources
Mus musculus	13646	MGI:95291
Mus musculus	13648	MGI:95293
Mus musculus	16612	MGI:102850
Mus musculus	16613	MGI:892023
Mus musculus	16615	MGI:891982
Mus musculus	16616	MGI:892022
Mus musculus	16617	MGI:892021
Mus musculus	16618	MGI:891981
Mus musculus	16619	MGI:891980
Mus musculus	16622	MGI:892020

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements