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Down syndrome cell adhesion molecule 1

Summary

Gene Symbol

Dscam1

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

35652

PubChem

35652

Alliance of Genome Resources

FB:FBgn0033159

Annotation

Keyword

3D-structure
Alternative splicing
Cell adhesion
Cell membrane
Cell projection
Direct protein sequencing
Disulfide bond
Glycoprotein
Immunoglobulin domain
Neurogenesis
Proteomics identification
Reference proteome
Repeat
Secreted
Signal
Transmembrane helix

Proteins

Displaying entries **1 - 10** of 62 in total

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UniProt	Protein Name
A1Z6X2
Q0E9L6
Q0E9K0
Q0E9K1
A0A0B4K7I3
A0A0B4K6S2
A0A0B4K828
A0A0B4K7T6
A0A0B4K7H9
Q0E9I7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **16 - 17** of 17 in total

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GO Term	Evidence Code	PMID
regulation of axonogenesis	IMP	17581959
regulation of dendrite morphogenesis	IGI IMP	16474389 17581959 25653356

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion [inference]

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

homophilic cell adhesion via plasma membrane adhesion molecules

cell recognition [inference]

neuron recognition [inference]

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension [inference]

axon extension involved in axon guidance

neuron projection extension involved in neuron projection guidance [inference]

axon extension involved in axon guidance

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis

cellular developmental process [inference]

cell development [inference]

neuron development

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

neuron projection fasciculation [inference]

axonal fasciculation

developmental process [inference]

anatomical structure morphogenesis [inference]

central nervous system morphogenesis

anatomical structure development [inference]

mushroom body development

cell development [inference]

neuron development

animal organ development [inference]

ventral cord development

system development [inference]

cellular developmental process [inference]

cell development [inference]

neuron development

growth [inference]

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension [inference]

axon extension involved in axon guidance

neuron projection extension involved in neuron projection guidance [inference]

axon extension involved in axon guidance

developmental growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension [inference]

axon extension involved in axon guidance

neuron projection extension involved in neuron projection guidance [inference]

axon extension involved in axon guidance

developmental growth involved in morphogenesis [inference]

neuron projection extension [inference]

axon extension [inference]

axon extension involved in axon guidance

neuron projection extension involved in neuron projection guidance [inference]

axon extension involved in axon guidance

response to stimulus [inference]

response to external stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of touch

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of touch

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

detection of molecule of bacterial origin

detection of external biotic stimulus [inference]

detection of molecule of bacterial origin

response to biotic stimulus [inference]

detection of biotic stimulus [inference]

detection of external biotic stimulus [inference]

detection of molecule of bacterial origin

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

detection of molecule of bacterial origin

detection of external biotic stimulus [inference]

detection of molecule of bacterial origin

response to abiotic stimulus [inference]

detection of abiotic stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of touch

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of touch

response to chemical [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

detection of molecule of bacterial origin

detection of stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of touch

detection of abiotic stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of touch

detection of chemical stimulus [inference]

detection of molecule of bacterial origin

detection of biotic stimulus [inference]

detection of external biotic stimulus [inference]

detection of molecule of bacterial origin

detection of stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of touch

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis

import into cell [inference]

endocytosis [inference]

phagocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of dendrite development [inference]

regulation of dendrite morphogenesis

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of axonogenesis

regulation of dendrite development [inference]

regulation of dendrite morphogenesis

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
dendrite	IDA	17482551
axon	IBA IDA	17482551

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

membrane [inference]

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

perikaryon

cell body [inference]

neuronal cell body

Displaying **all 5** entries
GO Term	Evidence Code	PMID
axon guidance receptor activity	IMP	15339666
identical protein binding	IPI	17889655
antigen binding	IDA	16109846
protein homodimerization activity	IPI	18805093
cell-cell adhesion mediator activity	IBA

GO Hierarchy

molecular function

binding [inference]

antigen binding

protein binding [inference]

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

cell adhesion molecule binding [inference]

cell adhesion mediator activity [inference]

cell-cell adhesion mediator activity

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

axon guidance receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

down syndrome cell adhesion molecule-like protein

Functional Category

K: Transcription
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
brain development
cell-cell adhesion mediator activity

Displaying **all 8** entries
InterPro
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin I-set
Immunoglobulin subtype 2
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold

Alliance of Genome Resources

Expression

Displaying **all 5** entries
Location	References
neuron projection	PMID:19211897
membrane	FB:FBrf0231198
neuronal cell body	PMID:17482551 PMID:19211897
axon	PMID:17482551
dendrite	PMID:17482551

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060041	autism spectrum disorder	Alliance of Genome Resources
DOID:14250	Down syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 47 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	100491996		Xenbase:XB-GENE-922538
Drosophila suzukii	108017950	28584_0:00241e
Drosophila biarmipes	108030033	125945_1:001f78
Drosophila rhopaloa	108042439	1041015_1:000930
Drosophila takahashii	108067123	29030_1:000fd8
Drosophila kikkawai	108081318	30033_1:001fb2
Drosophila ficusphila	108094287	30025_0:000fe0
Drosophila eugracilis	108112570	29029_1:0032d9
Drosophila bipectinata	108123090	42026_0:00152d
Drosophila elegans	108149589	30023_0:003054

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Last updated: December 9, 2024