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interleukin 5 receptor subunit alpha

Summary

Gene Symbol

IL5RA

Organism

Homo sapiens (human)

External Links

NCBI Gene

3568

PubChem

3568

Alliance of Genome Resources

HGNC:6017

Annotation

Keyword

3D-structure
Alternative splicing
Disulfide bond
Glycoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q8NHV7
Q01344	CDw125

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
regulation of interleukin-5 production	IEA
signal transduction	TAS	1732409
positive regulation of cell population proliferation	IBA
inflammatory response to antigenic stimulus	IEA
interleukin-5-mediated signaling pathway	IDA	22528658

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

inflammatory response to antigenic stimulus

cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

interleukin-5-mediated signaling pathway

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response [inference]

inflammatory response to antigenic stimulus

immune response [inference]

inflammatory response to antigenic stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of interleukin-5 production

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of interleukin-5 production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of interleukin-5 production

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of leukocyte proliferation

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

interleukin-5-mediated signaling pathway

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of interleukin-5 production

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of leukocyte proliferation

regulation of leukocyte proliferation [inference]

positive regulation of leukocyte proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of leukocyte proliferation

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

regulation of interleukin-5 production

Displaying **all 5** entries
GO Term	Evidence Code	PMID
plasma membrane	IDA TAS	1495999
extracellular space	TAS	1495999
external side of plasma membrane	IBA
membrane	TAS	1495999
receptor complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

extracellular space

membrane

plasma membrane

side of membrane [inference]

external side of plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
interleukin-5 receptor activity	IDA	22528658
cytokine binding	IBA
protein binding	IPI	12842047 1495999 22153509 9516124
cytokine receptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

cytokine binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity

interleukin-5 receptor activity

immune receptor activity [inference]

cytokine receptor activity

interleukin-5 receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Erythropoietin receptor

Functional Category

C: Energy production and conversion
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
cytokine-mediated signaling pathway

Displaying **all 2** entries
InterPro
Fibronectin type III superfamily
Immunoglobulin-like fold

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:1273	respiratory syncytial virus infectious disease	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources
DOID:3083	chronic obstructive pulmonary disease	Alliance of Genome Resources
DOID:350	mastocytosis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 55 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	16192		MGI:96558	MOUSE49457
Rattus norvegicus	114103		RGD:70938	RATNO32060
Xenopus laevis	447644		Xenbase:XB-GENE-6253595
Macaca mulatta	704649			MACMU27865
Pan troglodytes	737582	9598_0:000ee6		PANTR30289
Ornithorhynchus anatinus	100093035			ORNAN27746
Sus scrofa	100137085			PIGXX04479
Xenopus tropicalis	100144707		Xenbase:XB-GENE-481775
Cavia porcellus	100379257			CAVPO09038
Callithrix jacchus	100414222			CALJA11906

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements