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C-X-C motif chemokine receptor 1

Summary

Gene Symbol

CXCR1

Organism

Homo sapiens (human)

External Links

NCBI Gene

3577

PubChem

3577

Alliance of Genome Resources

HGNC:6026

Annotation

Keyword

3D-structure
Cell membrane
Chemotaxis
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P25024	CDw128a High affinity interleukin-8 receptor A IL-8 receptor type 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
receptor internalization	IDA	10734056
calcium-mediated signaling	IBA
cell surface receptor signaling pathway	IDA	10734056
neutrophil chemotaxis	IBA
chemokine-mediated signaling pathway	IEA

GO Hierarchy

biological process

immune system process [inference]

immune response

leukocyte migration [inference]

leukocyte chemotaxis [inference]

dendritic cell chemotaxis

granulocyte chemotaxis [inference]

neutrophil chemotaxis

mononuclear cell migration [inference]

dendritic cell migration [inference]

dendritic cell chemotaxis

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration [inference]

neutrophil chemotaxis

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

cytokine-mediated signaling pathway [inference]

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

dendritic cell chemotaxis

granulocyte chemotaxis [inference]

neutrophil chemotaxis

mononuclear cell migration [inference]

dendritic cell migration [inference]

dendritic cell chemotaxis

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration [inference]

neutrophil chemotaxis

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

dendritic cell chemotaxis

granulocyte chemotaxis [inference]

neutrophil chemotaxis

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

dendritic cell chemotaxis

granulocyte chemotaxis [inference]

neutrophil chemotaxis

response to stimulus [inference]

immune response

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

cytokine-mediated signaling pathway [inference]

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

Displaying **all 3** entries
GO Term	Evidence Code	PMID
external side of plasma membrane	IBA
secretory granule membrane	TAS
plasma membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane

bounding membrane of organelle [inference]

secretory granule membrane

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	30384436 32296183
interleukin-8 receptor activity	IDA	10734056
interleukin-8 binding	IPI	11564821
chemokine receptor activity	TAS	1840701
C-C chemokine receptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

cytokine binding [inference]

chemokine binding [inference]

C-C chemokine binding

C-X-C chemokine binding [inference]

interleukin-8 binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity [inference]

chemokine receptor activity

C-C chemokine receptor activity

C-X-C chemokine receptor activity [inference]

interleukin-8 receptor activity

G protein-coupled receptor activity

G protein-coupled chemoattractant receptor activity [inference]

chemokine receptor activity

C-C chemokine receptor activity

C-X-C chemokine receptor activity [inference]

interleukin-8 receptor activity

immune receptor activity [inference]

cytokine receptor activity [inference]

chemokine receptor activity

C-C chemokine receptor activity

C-X-C chemokine receptor activity [inference]

interleukin-8 receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

receptor 2

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 9** entries
Gene Ontology
C-C chemokine binding
C-C chemokine receptor activity
C-X-C chemokine receptor activity
calcium-mediated signaling
chemokine-mediated signaling pathway
chemotaxis
immune response
neutrophil chemotaxis
positive regulation of cytosolic calcium ion concentration

Displaying **all 3** entries
InterPro
CXC chemokine receptor 1/2
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0080784	urinary tract infection	Alliance of Genome Resources
DOID:11400	pyelonephritis	Alliance of Genome Resources
DOID:2920	membranoproliferative glomerulonephritis	Alliance of Genome Resources
DOID:526	human immunodeficiency virus infectious disease	Alliance of Genome Resources
DOID:783	end stage renal disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 95 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	12765			MOUSE30495
Rattus norvegicus	29385			RATNO42852
Rattus norvegicus	54258		RGD:2905
Caenorhabditis elegans	188226		WB:WBGene00011578
Mus musculus	227288		MGI:2448715
Bos taurus	281863			BOVIN24739
Pan troglodytes	470645	9598_0:000c6d		PANTR29752
Canis lupus familiaris	478905			CANLF14212
Macaca mulatta	692074			MACMU05778
Bos taurus	782719			BOVIN24738

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements