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C-X-C motif chemokine receptor 2

Summary

Gene Symbol

CXCR2

Organism

Homo sapiens (human)

External Links

NCBI Gene

3579

PubChem

3579

Alliance of Genome Resources

HGNC:6027

Annotation

Keyword

3D-structure
Cell membrane
Chemotaxis
Disulfide bond
G-protein coupled receptor
Glycoprotein
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q53PC4	High affinity interleukin-8 receptor B
P25025	CDw128b GRO/MGSA receptor High affinity interleukin-8 receptor B IL-8 receptor type 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
chemotaxis	IDA	10725748
positive regulation of cell population proliferation	IDA	10438939
receptor internalization	IDA	10734056
calcium-mediated signaling	IBA
cell surface receptor signaling pathway	IDA	10734056 10878382

GO Hierarchy

biological process

immune system process [inference]

immune response

leukocyte activation [inference]

myeloid leukocyte activation [inference]

granulocyte activation [inference]

neutrophil activation

leukocyte migration [inference]

leukocyte chemotaxis [inference]

dendritic cell chemotaxis

granulocyte chemotaxis [inference]

neutrophil chemotaxis

mononuclear cell migration [inference]

dendritic cell migration [inference]

dendritic cell chemotaxis

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration [inference]

neutrophil chemotaxis

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

granulocyte activation [inference]

neutrophil activation

signal transduction

cell surface receptor signaling pathway

cytokine-mediated signaling pathway [inference]

G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

dendritic cell chemotaxis

granulocyte chemotaxis [inference]

neutrophil chemotaxis

mononuclear cell migration [inference]

dendritic cell migration [inference]

dendritic cell chemotaxis

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration [inference]

neutrophil chemotaxis

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

dendritic cell chemotaxis

granulocyte chemotaxis [inference]

neutrophil chemotaxis

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

myeloid leukocyte activation [inference]

granulocyte activation [inference]

neutrophil activation

locomotion [inference]

taxis [inference]

chemotaxis

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

dendritic cell chemotaxis

granulocyte chemotaxis [inference]

neutrophil chemotaxis

response to stimulus [inference]

response to stress [inference]

defense response [inference]

immune response

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway

cytokine-mediated signaling pathway [inference]

G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
external side of plasma membrane	IBA
secretory granule membrane	TAS
membrane	IDA	10725748
mast cell granule	IDA	9725262
plasma membrane	IDA TAS	10438939

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane

bounding membrane of organelle [inference]

secretory granule membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome [inference]

mast cell granule

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle [inference]

mitotic spindle

cytoskeleton [inference]

microtubule cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome [inference]

mast cell granule

intracellular non-membrane-bounded organelle [inference]

spindle [inference]

mitotic spindle

cytoskeleton [inference]

microtubule cytoskeleton

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	17435771 21876773 22904195 23597562 32296183 36613703
interleukin-8 receptor activity	IDA	10820279
interleukin-8 binding	IPI	1840701
C-X-C chemokine receptor activity	IDA	10878382
C-C chemokine receptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

cytokine binding [inference]

chemokine binding [inference]

C-C chemokine binding

C-X-C chemokine binding [inference]

interleukin-8 binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity [inference]

chemokine receptor activity [inference]

C-C chemokine receptor activity

C-X-C chemokine receptor activity

interleukin-8 receptor activity

G protein-coupled receptor activity

G protein-coupled chemoattractant receptor activity [inference]

chemokine receptor activity [inference]

C-C chemokine receptor activity

C-X-C chemokine receptor activity

interleukin-8 receptor activity

immune receptor activity [inference]

cytokine receptor activity [inference]

chemokine receptor activity [inference]

C-C chemokine receptor activity

C-X-C chemokine receptor activity

interleukin-8 receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

receptor 2

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 9** entries
Gene Ontology
C-C chemokine binding
C-C chemokine receptor activity
C-X-C chemokine receptor activity
calcium-mediated signaling
chemokine-mediated signaling pathway
chemotaxis
immune response
neutrophil chemotaxis
positive regulation of cytosolic calcium ion concentration

Displaying **all 3** entries
InterPro
CXC chemokine receptor 1/2
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying entries **1 - 10** of 11 in total

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DO ID	Disease Name	Source
DOID:0060180	colitis	Alliance of Genome Resources
DOID:10952	nephritis	Alliance of Genome Resources
DOID:11054	urinary bladder cancer	Alliance of Genome Resources
DOID:2154	nephroblastoma	Alliance of Genome Resources
DOID:2986	IgA glomerulonephritis	Alliance of Genome Resources
DOID:3083	chronic obstructive pulmonary disease	Alliance of Genome Resources
DOID:3213	demyelinating disease	Alliance of Genome Resources
DOID:559	acute pyelonephritis	Alliance of Genome Resources
DOID:783	end stage renal disease	Alliance of Genome Resources
DOID:823	periapical periodontitis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 91 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	12765		MGI:105303	MOUSE30495
Rattus norvegicus	29385		RGD:2906	RATNO42852
Caenorhabditis elegans	188226		WB:WBGene00011578
Bos taurus	281863			BOVIN24739
Pan troglodytes	470644	9598_0:000dba		PANTR29751
Canis lupus familiaris	478905			CANLF14212
Macaca mulatta	700407			MACMU05771
Bos taurus	782719			BOVIN24738
Danio rerio	796724		ZFIN:ZDB-GENE-100414-1	DANRE43923
Monodelphis domestica	100012266			MONDO31516

GlyTouCan

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements