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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
interleukin 10
Summary
- Gene Symbol
-
- IL10
- Organism
- Homo sapiens (human)
Annotation
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| positive regulation of cytokine production | ||
| regulation of synapse organization | ||
| negative regulation of tumor necrosis factor production | ||
| type 2 immune response | ||
| positive regulation of DNA-binding transcription factor activity |
GO Hierarchy
- negative regulation of cytokine production involved in immune response
- negative regulation of type II interferon production
- negative regulation of interleukin-1 production
- negative regulation of interleukin-12 production
- negative regulation of interleukin-18 production
- negative regulation of interleukin-6 production
- negative regulation of interleukin-8 production
- negative regulation of MHC class II biosynthetic process
- negative regulation of nitric oxide biosynthetic process
- negative regulation of cytokine production involved in immune response
- negative regulation of type II interferon production
- negative regulation of interleukin-1 production
- negative regulation of interleukin-12 production
- negative regulation of interleukin-18 production
- negative regulation of interleukin-6 production
- negative regulation of interleukin-8 production
- positive regulation of cytokine production
- negative regulation of cytokine production involved in immune response
- negative regulation of type II interferon production
- negative regulation of interleukin-1 production
- negative regulation of interleukin-12 production
- negative regulation of interleukin-18 production
- negative regulation of interleukin-6 production
- negative regulation of interleukin-8 production
- negative regulation of cytokine production involved in immune response
- negative regulation of type II interferon production
- negative regulation of interleukin-1 production
- negative regulation of interleukin-12 production
- negative regulation of interleukin-18 production
- negative regulation of interleukin-6 production
- negative regulation of interleukin-8 production
- negative regulation of MHC class II biosynthetic process
- negative regulation of cytokine production involved in immune response
- negative regulation of type II interferon production
- negative regulation of interleukin-1 production
- negative regulation of interleukin-12 production
- negative regulation of interleukin-18 production
- negative regulation of interleukin-6 production
- negative regulation of interleukin-8 production
- negative regulation of MHC class II biosynthetic process
- negative regulation of nitric oxide biosynthetic process
- negative regulation of cytokine production involved in immune response
- negative regulation of type II interferon production
- negative regulation of interleukin-1 production
- negative regulation of interleukin-12 production
- negative regulation of interleukin-18 production
- negative regulation of interleukin-6 production
- negative regulation of interleukin-8 production
- negative regulation of MHC class II biosynthetic process
- negative regulation of nitric oxide biosynthetic process
- negative regulation of cytokine production involved in immune response
- negative regulation of type II interferon production
- negative regulation of interleukin-1 production
- negative regulation of interleukin-12 production
- negative regulation of interleukin-18 production
- negative regulation of interleukin-6 production
- negative regulation of interleukin-8 production
- negative regulation of MHC class II biosynthetic process
- negative regulation of cytokine production involved in immune response
- negative regulation of type II interferon production
- negative regulation of interleukin-1 production
- negative regulation of interleukin-12 production
- negative regulation of interleukin-18 production
- negative regulation of interleukin-6 production
- negative regulation of interleukin-8 production
- negative regulation of MHC class II biosynthetic process
- negative regulation of nitric oxide biosynthetic process
- negative regulation of cytokine production involved in immune response
- negative regulation of type II interferon production
- negative regulation of interleukin-1 production
- negative regulation of interleukin-12 production
- negative regulation of interleukin-18 production
- negative regulation of interleukin-6 production
- negative regulation of interleukin-8 production
- negative regulation of MHC class II biosynthetic process
- negative regulation of nitric oxide biosynthetic process
- negative regulation of cytokine production involved in immune response
- negative regulation of type II interferon production
- negative regulation of interleukin-1 production
- negative regulation of interleukin-12 production
- negative regulation of interleukin-18 production
- negative regulation of interleukin-6 production
- negative regulation of interleukin-8 production
- positive regulation of cytokine production
- negative regulation of cytokine production involved in immune response
- negative regulation of type II interferon production
- negative regulation of interleukin-1 production
- negative regulation of interleukin-12 production
- negative regulation of interleukin-18 production
- negative regulation of interleukin-6 production
- negative regulation of interleukin-8 production
- negative regulation of cytokine production involved in immune response
- negative regulation of type II interferon production
- negative regulation of interleukin-1 production
- negative regulation of interleukin-12 production
- negative regulation of interleukin-18 production
- negative regulation of interleukin-6 production
- negative regulation of interleukin-8 production
- negative regulation of MHC class II biosynthetic process
- negative regulation of cytokine production involved in immune response
- negative regulation of type II interferon production
- negative regulation of interleukin-1 production
- negative regulation of interleukin-12 production
- negative regulation of interleukin-18 production
- negative regulation of interleukin-6 production
- negative regulation of interleukin-8 production
- negative regulation of MHC class II biosynthetic process
- negative regulation of nitric oxide biosynthetic process
- negative regulation of cytokine production involved in immune response
- negative regulation of type II interferon production
- negative regulation of interleukin-1 production
- negative regulation of interleukin-12 production
- negative regulation of interleukin-18 production
- negative regulation of interleukin-6 production
- negative regulation of interleukin-8 production
- positive regulation of cytokine production
- negative regulation of cytokine production involved in immune response
- negative regulation of type II interferon production
- negative regulation of interleukin-1 production
- negative regulation of interleukin-12 production
- negative regulation of interleukin-18 production
- negative regulation of interleukin-6 production
- negative regulation of interleukin-8 production
- negative regulation of cytokine production involved in immune response
- negative regulation of type II interferon production
- negative regulation of interleukin-1 production
- negative regulation of interleukin-12 production
- negative regulation of interleukin-18 production
- negative regulation of interleukin-6 production
- negative regulation of interleukin-8 production
- negative regulation of MHC class II biosynthetic process
- negative regulation of cytokine production involved in immune response
- negative regulation of type II interferon production
- negative regulation of interleukin-1 production
- negative regulation of interleukin-12 production
- negative regulation of interleukin-18 production
- negative regulation of interleukin-6 production
- negative regulation of interleukin-8 production
- negative regulation of MHC class II biosynthetic process
- negative regulation of cytokine production involved in immune response
- negative regulation of type II interferon production
- negative regulation of interleukin-1 production
- negative regulation of interleukin-12 production
- negative regulation of interleukin-18 production
- negative regulation of interleukin-6 production
- negative regulation of interleukin-8 production
- negative regulation of MHC class II biosynthetic process
- negative regulation of nitric oxide biosynthetic process
- negative regulation of cytokine production involved in immune response
- negative regulation of type II interferon production
- negative regulation of interleukin-1 production
- negative regulation of interleukin-12 production
- negative regulation of interleukin-18 production
- negative regulation of interleukin-6 production
- negative regulation of interleukin-8 production
- negative regulation of MHC class II biosynthetic process
- negative regulation of cytokine production involved in immune response
- negative regulation of type II interferon production
- negative regulation of interleukin-1 production
- negative regulation of interleukin-12 production
- negative regulation of interleukin-18 production
- negative regulation of interleukin-6 production
- negative regulation of interleukin-8 production
- negative regulation of MHC class II biosynthetic process
- negative regulation of nitric oxide biosynthetic process
- negative regulation of cytokine production involved in immune response
- negative regulation of type II interferon production
- negative regulation of interleukin-1 production
- negative regulation of interleukin-12 production
- negative regulation of interleukin-18 production
- negative regulation of interleukin-6 production
- negative regulation of interleukin-8 production
- negative regulation of MHC class II biosynthetic process
- negative regulation of nitric oxide biosynthetic process
- negative regulation of cytokine production involved in immune response
- negative regulation of type II interferon production
- negative regulation of interleukin-1 production
- negative regulation of interleukin-12 production
- negative regulation of interleukin-18 production
- negative regulation of interleukin-6 production
- negative regulation of interleukin-8 production
- negative regulation of cytokine production involved in immune response
- negative regulation of type II interferon production
- negative regulation of interleukin-1 production
- negative regulation of interleukin-12 production
- negative regulation of interleukin-18 production
- negative regulation of interleukin-6 production
- negative regulation of interleukin-8 production
- negative regulation of MHC class II biosynthetic process
- negative regulation of nitric oxide biosynthetic process
- negative regulation of cytokine production involved in immune response
- negative regulation of type II interferon production
- negative regulation of interleukin-1 production
- negative regulation of interleukin-12 production
- negative regulation of interleukin-18 production
- negative regulation of interleukin-6 production
- negative regulation of interleukin-8 production
- positive regulation of cytokine production
- negative regulation of cytokine production involved in immune response
- negative regulation of type II interferon production
- negative regulation of interleukin-1 production
- negative regulation of interleukin-12 production
- negative regulation of interleukin-18 production
- negative regulation of interleukin-6 production
- negative regulation of interleukin-8 production
- negative regulation of cytokine production involved in immune response
- negative regulation of type II interferon production
- negative regulation of interleukin-1 production
- negative regulation of interleukin-12 production
- negative regulation of interleukin-18 production
- negative regulation of interleukin-6 production
- negative regulation of interleukin-8 production
- negative regulation of MHC class II biosynthetic process
- negative regulation of cytokine production involved in immune response
- negative regulation of type II interferon production
- negative regulation of interleukin-1 production
- negative regulation of interleukin-12 production
- negative regulation of interleukin-18 production
- negative regulation of interleukin-6 production
- negative regulation of interleukin-8 production
- negative regulation of MHC class II biosynthetic process
- negative regulation of nitric oxide biosynthetic process
- negative regulation of cytokine production involved in immune response
- negative regulation of type II interferon production
- negative regulation of interleukin-1 production
- negative regulation of interleukin-12 production
- negative regulation of interleukin-18 production
- negative regulation of interleukin-6 production
- negative regulation of interleukin-8 production
- negative regulation of MHC class II biosynthetic process
- negative regulation of nitric oxide biosynthetic process
- negative regulation of cytokine production involved in immune response
- negative regulation of type II interferon production
- negative regulation of interleukin-1 production
- negative regulation of interleukin-12 production
- negative regulation of interleukin-18 production
- negative regulation of interleukin-6 production
- negative regulation of interleukin-8 production
- positive regulation of cytokine production
- negative regulation of cytokine production involved in immune response
- negative regulation of type II interferon production
- negative regulation of interleukin-1 production
- negative regulation of interleukin-12 production
- negative regulation of interleukin-18 production
- negative regulation of interleukin-6 production
- negative regulation of interleukin-8 production
biological process
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
negative regulation of immune system process [inference]
positive regulation of immune system process [inference]
regulation of leukocyte activation [inference]
regulation of immune effector process [inference]
regulation of immune response [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of biosynthetic process [inference]
negative regulation of cellular biosynthetic process [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of gene expression [inference]
negative regulation of cytokine production
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression
regulation of cytokine production [inference]
negative regulation of cytokine production
regulation of production of molecular mediator of immune response [inference]
regulation of DNA-templated transcription [inference]
negative regulation of gene expression [inference]
negative regulation of cytokine production
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of gene expression [inference]
negative regulation of cytokine production
negative regulation of cellular biosynthetic process [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of gene expression [inference]
negative regulation of cytokine production
negative regulation of metabolic process [inference]
negative regulation of biosynthetic process [inference]
negative regulation of cellular biosynthetic process [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of gene expression [inference]
negative regulation of cytokine production
negative regulation of macromolecule metabolic process [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of gene expression [inference]
negative regulation of cytokine production
negative regulation of cellular metabolic process [inference]
negative regulation of cellular biosynthetic process [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of gene expression [inference]
negative regulation of cytokine production
positive regulation of metabolic process [inference]
regulation of catabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
negative regulation of cellular biosynthetic process [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of gene expression [inference]
negative regulation of cytokine production
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression
regulation of cytokine production [inference]
negative regulation of cytokine production
regulation of production of molecular mediator of immune response [inference]
regulation of DNA-templated transcription [inference]
negative regulation of gene expression [inference]
negative regulation of cytokine production
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of gene expression [inference]
negative regulation of cytokine production
negative regulation of cellular biosynthetic process [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of gene expression [inference]
negative regulation of cytokine production
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression
regulation of cytokine production [inference]
negative regulation of cytokine production
regulation of production of molecular mediator of immune response [inference]
regulation of DNA-templated transcription [inference]
negative regulation of gene expression [inference]
negative regulation of cytokine production
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of gene expression [inference]
negative regulation of cytokine production
positive regulation of macromolecule metabolic process [inference]
negative regulation of macromolecule metabolic process [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of gene expression [inference]
negative regulation of cytokine production
regulation of protein metabolic process [inference]
regulation of RNA metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of metabolic process [inference]
positive regulation of cellular process [inference]
negative regulation of biological process [inference]
negative regulation of immune system process [inference]
negative regulation of metabolic process [inference]
negative regulation of biosynthetic process [inference]
negative regulation of cellular biosynthetic process [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of gene expression [inference]
negative regulation of cytokine production
negative regulation of macromolecule metabolic process [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of gene expression [inference]
negative regulation of cytokine production
negative regulation of cellular metabolic process [inference]
negative regulation of cellular biosynthetic process [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of gene expression [inference]
negative regulation of cytokine production
negative regulation of cellular process [inference]
negative regulation of cellular metabolic process [inference]
negative regulation of cellular biosynthetic process [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of gene expression [inference]
negative regulation of cytokine production
negative regulation of programmed cell death [inference]
negative regulation of response to stimulus [inference]
negative regulation of multicellular organismal process [inference]
negative regulation of cytokine production
regulation of response to stimulus [inference]
regulation of signal transduction [inference]
regulation of response to external stimulus [inference]
negative regulation of response to stimulus [inference]
regulation of immune response [inference]
regulation of response to stress [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cell adhesion [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
negative regulation of cellular biosynthetic process [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of gene expression [inference]
negative regulation of cytokine production
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression
regulation of cytokine production [inference]
negative regulation of cytokine production
regulation of production of molecular mediator of immune response [inference]
regulation of DNA-templated transcription [inference]
negative regulation of gene expression [inference]
negative regulation of cytokine production
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of gene expression [inference]
negative regulation of cytokine production
negative regulation of cellular biosynthetic process [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of gene expression [inference]
negative regulation of cytokine production
regulation of cell population proliferation [inference]
regulation of programmed cell death [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
negative regulation of cellular metabolic process [inference]
negative regulation of cellular biosynthetic process [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of gene expression [inference]
negative regulation of cytokine production
negative regulation of programmed cell death [inference]
regulation of cell activation [inference]
regulation of multicellular organismal process [inference]
regulation of cytokine production [inference]
negative regulation of cytokine production
regulation of cell activation [inference]
positive regulation of multicellular organismal process [inference]
negative regulation of multicellular organismal process [inference]
negative regulation of cytokine production
regulation of molecular function [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular region | ||
| extracellular space |
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| protein dimerization activity | ||
| interleukin-10 receptor binding | ||
| cytokine activity | ||
| growth factor activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- interleukin-10
- Functional Category
-
- G: Carbohydrate transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| cytokine activity |
| immune response |
| InterPro |
|---|
| Four-helical cytokine-like, core |
| Interleukin-10/19/20/22/24/26 family |
| Interleukin-10 |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050523 | adult T-cell leukemia/lymphoma | |
| DOID:0050589 | inflammatory bowel disease | |
| DOID:0050827 | rheumatic heart disease | |
| DOID:0050848 | obstructive sleep apnea | |
| DOID:0050865 | tongue squamous cell carcinoma | |
| DOID:0050866 | oral squamous cell carcinoma | |
| DOID:0060180 | colitis | |
| DOID:0060901 | lymphoplasmacytic lymphoma | |
| DOID:0070344 | ocular tuberculosis | |
| DOID:0080208 | metabolic dysfunction-associated steatotic liver disease |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 16153 | MGI:96537 | MOUSE28471 | ||
| 25325 | RGD:2886 | RATNO07002 | ||
| 281246 | BOVIN07927 | |||
| 397106 | PIGXX35950 | |||
| 403628 | CANLF17078 | |||
| 443342 | SHEEP03532 | |||
| 469657 | 9598_0:000043 | PANTR23532 | ||
| 493683 | FELCA36265 | |||
| 553957 | ZFIN:ZDB-GENE-051111-1 | DANRE02413 | ||
| 694931 | MACMU25430 |
