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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
interleukin 12A
Summary
- Gene Symbol
-
- IL12A
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Cytokine
- Direct protein sequencing
- Disulfide bond
- Glycoprotein
- Growth factor
- Host-virus interaction
- Proteomics identification
- Reference proteome
- Secreted
- Signal
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| negative regulation of vascular endothelial growth factor signaling pathway | ||
| positive regulation of T cell mediated cytotoxicity | ||
| positive regulation of cell adhesion | ||
| cellular response to virus | ||
| positive regulation of dendritic cell chemotaxis |
GO Hierarchy
biological process
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
positive regulation of immune system process [inference]
regulation of leukocyte migration [inference]
regulation of leukocyte activation [inference]
regulation of immune effector process [inference]
positive regulation of immune effector process [inference]
regulation of leukocyte mediated immunity [inference]
regulation of immune response [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of localization [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of metabolic process [inference]
positive regulation of cellular process [inference]
positive regulation of response to stimulus [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of response to biotic stimulus [inference]
regulation of response to external stimulus [inference]
positive regulation of response to stimulus [inference]
regulation of immune response [inference]
regulation of response to stress [inference]
regulation of cellular process [inference]
regulation of cellular metabolic process [inference]
regulation of cell killing [inference]
regulation of cell population proliferation [inference]
positive regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of cell motility [inference]
regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| endoplasmic reticulum lumen | ||
| extracellular region | ||
| late endosome lumen | ||
| extracellular space | ||
| interleukin-12 complex |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| interleukin-12 beta subunit binding | ||
| protein heterodimerization activity | ||
| interleukin-12 receptor binding | ||
| interleukin-27 binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- interleukin-12 subunit alpha
- Functional Category
-
- G: Carbohydrate transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| cytokine activity |
| growth factor activity |
| immune response |
| interleukin-12 receptor binding |
| InterPro |
|---|
| Four-helical cytokine-like, core |
| Interleukin-12 alpha |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:12236 | primary biliary cholangitis | |
| DOID:1883 | hepatitis C | |
| DOID:684 | hepatocellular carcinoma |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 16159 | MGI:96539 | MOUSE36394 | ||
| 84405 | RGD:620562 | RATNO22746 | ||
| 397053 | PIGXX05023 | |||
| 403977 | CANLF13595 | |||
| 443064 | SHEEP01677 | |||
| 445410 | ZFIN:ZDB-GENE-060724-1 | |||
| 460816 | 9598_0:0012ce | PANTR32559 | ||
| 493741 | FELCA23421 | |||
| 703205 | MACMU30047 | |||
| 100004358 | ZFIN:ZDB-GENE-140106-87 |
