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interleukin 13 receptor subunit alpha 2

Summary

Gene Symbol

IL13RA2

Organism

Homo sapiens (human)

External Links

NCBI Gene

3598

PubChem

3598

Alliance of Genome Resources

HGNC:5975

Annotation

Keyword

3D-structure
Disulfide bond
Glycoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q14627	Interleukin-13-binding protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
positive regulation of cell population proliferation	IBA
negative regulation of immunoglobulin production	IEA
cytokine-mediated signaling pathway	IBA
immunoglobulin mediated immune response	IEA
negative regulation of mast cell degranulation	IEA

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity [inference]

lymphocyte mediated immunity [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

response to stimulus [inference]

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of leukocyte mediated immunity [inference]

negative regulation of myeloid leukocyte mediated immunity [inference]

negative regulation of mast cell degranulation

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

regulation of immune effector process [inference]

negative regulation of immune effector process [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of leukocyte mediated immunity [inference]

negative regulation of myeloid leukocyte mediated immunity [inference]

negative regulation of mast cell degranulation

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

regulation of production of molecular mediator of immune response [inference]

regulation of immunoglobulin production [inference]

negative regulation of immunoglobulin production

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

regulation of leukocyte mediated immunity [inference]

negative regulation of leukocyte mediated immunity [inference]

negative regulation of myeloid leukocyte mediated immunity [inference]

negative regulation of mast cell degranulation

regulation of myeloid leukocyte mediated immunity [inference]

negative regulation of myeloid leukocyte mediated immunity [inference]

negative regulation of mast cell degranulation

regulation of mast cell degranulation [inference]

negative regulation of mast cell degranulation

regulation of leukocyte degranulation [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

regulation of mast cell degranulation [inference]

negative regulation of mast cell degranulation

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

regulation of immunoglobulin production [inference]

negative regulation of immunoglobulin production

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

regulation of immunoglobulin production [inference]

negative regulation of immunoglobulin production

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

regulation of immunoglobulin production [inference]

negative regulation of immunoglobulin production

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of exocytosis [inference]

negative regulation of regulated secretory pathway [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

negative regulation of exocytosis [inference]

negative regulation of regulated secretory pathway [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

regulation of mast cell degranulation [inference]

negative regulation of mast cell degranulation

negative regulation of regulated secretory pathway [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

negative regulation of secretion by cell [inference]

negative regulation of exocytosis [inference]

negative regulation of regulated secretory pathway [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of exocytosis [inference]

negative regulation of regulated secretory pathway [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

negative regulation of exocytosis [inference]

negative regulation of regulated secretory pathway [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

regulation of mast cell degranulation [inference]

negative regulation of mast cell degranulation

negative regulation of regulated secretory pathway [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of leukocyte mediated immunity [inference]

negative regulation of myeloid leukocyte mediated immunity [inference]

negative regulation of mast cell degranulation

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of secretion by cell [inference]

negative regulation of exocytosis [inference]

negative regulation of regulated secretory pathway [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of exocytosis [inference]

negative regulation of regulated secretory pathway [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

regulation of immunoglobulin production [inference]

negative regulation of immunoglobulin production

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of secretion by cell [inference]

negative regulation of exocytosis [inference]

negative regulation of regulated secretory pathway [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

negative regulation of exocytosis [inference]

negative regulation of regulated secretory pathway [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

regulation of mast cell degranulation [inference]

negative regulation of mast cell degranulation

negative regulation of regulated secretory pathway [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

negative regulation of exocytosis [inference]

negative regulation of regulated secretory pathway [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

regulation of regulated secretory pathway [inference]

regulation of leukocyte degranulation [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

regulation of mast cell degranulation [inference]

negative regulation of mast cell degranulation

negative regulation of regulated secretory pathway [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

negative regulation of secretion by cell [inference]

negative regulation of exocytosis [inference]

negative regulation of regulated secretory pathway [inference]

negative regulation of leukocyte degranulation [inference]

negative regulation of mast cell degranulation

Displaying **all 4** entries
GO Term	Evidence Code	PMID
external side of plasma membrane	IBA
receptor complex	IBA
extracellular region	TAS
extracellular space	TAS	9083087

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

side of membrane [inference]

external side of plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	20223216 23972995 27629921 28143526 29427412 32296183
cytokine receptor activity	IBA TAS	9725226
cytokine binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

cytokine binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity

immune receptor activity [inference]

cytokine receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

interleukin-13 receptor subunit alpha-2

Functional Category

G: Carbohydrate transport and metabolism
L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones

Displaying 1 entry
Gene Ontology
erythropoietin receptor activity

Displaying **all 4** entries
InterPro
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin-like fold
Type I cytokine receptor, cytokine-binding domain

Disease

Disease Ontology

Displaying **all 10** entries
DO ID	Disease Name	Source
DOID:0050866	oral squamous cell carcinoma	Alliance of Genome Resources
DOID:12930	dilated cardiomyopathy	Alliance of Genome Resources
DOID:1612	breast cancer	Alliance of Genome Resources
DOID:1793	pancreatic cancer	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources
DOID:3310	atopic dermatitis	Alliance of Genome Resources
DOID:4481	allergic rhinitis	Alliance of Genome Resources
DOID:552	pneumonia	Alliance of Genome Resources
DOID:6432	pulmonary hypertension	Alliance of Genome Resources
DOID:9452	steatotic liver disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 70 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	16165	MGI:1277954	MOUSE64567
Rattus norvegicus	171060	RGD:620838	RATNO45217
Danio rerio	368326	ZFIN:ZDB-GENE-030521-10
Canis lupus familiaris	403622		CANLF20075
Xenopus laevis	495398	Xenbase:XB-GENE-866197
Bos taurus	616008		BOVIN36776
Macaca mulatta	708339		MACMU47201
Monodelphis domestica	100010896		MONDO36326
Xenopus laevis	100049773	Xenbase:XB-GENE-17332181
Equus caballus	100057673		HORSE44589

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements