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BSCL2 lipid droplet biogenesis associated, seipin

Summary

Gene Symbol

Bscl2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

361722

PubChem

361722

Alliance of Genome Resources

RGD:1308135

Annotation

Keyword

Endoplasmic reticulum
Glycoprotein
Lipid degradation
Lipid droplet
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q5FVJ6	Bernardinelli-Seip congenital lipodystrophy type 2 protein homolog

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 26 in total

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GO Term	Evidence Code	PMID
spermatid differentiation	ISO
biological_process	ND
lipid droplet formation	IEA ISO ISS
multicellular organism growth	ISO
lipid droplet organization	IBA ISO ISS

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

electron transport chain [inference]

respiratory electron transport chain

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular lipid metabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

reactive oxygen species metabolic process

primary metabolic process [inference]

lipid metabolic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

cellular lipid metabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

organic substance metabolic process [inference]

lipid metabolic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

cellular lipid metabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular process [inference]

cellular process involved in reproduction in multicellular organism [inference]

spermatid differentiation

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

electron transport chain [inference]

respiratory electron transport chain

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular lipid metabolic process [inference]

cellular lipid catabolic process [inference]

cytosolic lipolysis

reactive oxygen species metabolic process

cellular developmental process [inference]

cell differentiation [inference]

cell development [inference]

muscle cell development [inference]

myotube cell development [inference]

skeletal muscle fiber development

maintenance of location in cell

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization

lipid droplet organization

lipid droplet formation

chromosome organization

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

lipid droplet formation

cellular component assembly [inference]

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

lipid droplet formation

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatid differentiation

cellular process involved in reproduction in multicellular organism [inference]

spermatid differentiation

multicellular organismal process [inference]

determination of adult lifespan

molting cycle process [inference]

hair cycle process [inference]

hair follicle development

multicellular organism growth

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis

developmental process [inference]

developmental process involved in reproduction [inference]

spermatid differentiation

anatomical structure development [inference]

hair follicle development

tissue development [inference]

connective tissue development [inference]

adipose tissue development

cell development [inference]

muscle cell development [inference]

myotube cell development [inference]

skeletal muscle fiber development

system development [inference]

cellular developmental process [inference]

cell differentiation [inference]

cell development [inference]

muscle cell development [inference]

myotube cell development [inference]

skeletal muscle fiber development

growth [inference]

developmental growth [inference]

multicellular organism growth

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis

localization [inference]

maintenance of location [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of phosphatidic acid biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidic acid biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of lipid catabolic process

negative regulation of lipid metabolic process [inference]

negative regulation of lipid catabolic process

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of lipid catabolic process

regulation of lipid catabolic process [inference]

negative regulation of lipid catabolic process

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of phosphatidic acid biosynthetic process

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phospholipid metabolic process [inference]

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidic acid biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

negative regulation of lipid metabolic process [inference]

negative regulation of lipid catabolic process

regulation of lipid biosynthetic process [inference]

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidic acid biosynthetic process

regulation of lipid catabolic process [inference]

negative regulation of lipid catabolic process

regulation of phospholipid metabolic process [inference]

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidic acid biosynthetic process

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of lipid catabolic process

negative regulation of lipid metabolic process [inference]

negative regulation of lipid catabolic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of phosphatidic acid biosynthetic process

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phospholipid metabolic process [inference]

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidic acid biosynthetic process

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity

Displaying **all 5** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	IBA IEA ISO ISS
endoplasmic reticulum	ISO
lipid droplet	IEA ISO
cytosol	IEA
cytoplasm	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

lipid droplet

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular non-membrane-bounded organelle [inference]

lipid droplet

Displaying **all 2** entries
GO Term	Evidence Code	PMID
phospholipid binding	IEA ISO
molecular_function	ND

GO Hierarchy

molecular function

binding [inference]

lipid binding [inference]

phospholipid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

G-protein gamma-like domain

Functional Category

G: Carbohydrate transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
lipid droplet formation
lipid droplet organization
lipid metabolic process
lipid storage

Displaying 1 entry
InterPro
Seipin family

Disease

Disease Ontology

Displaying **all 9** entries
DO ID	Disease Name	Source
DOID:0050585	congenital generalized lipodystrophy	Alliance of Genome Resources
DOID:0081401	autosomal dominant distal hereditary motor neuronopathy 13	Alliance of Genome Resources
DOID:0110770	hereditary spastic paraplegia 17	Alliance of Genome Resources
DOID:0111136	congenital generalized lipodystrophy type 2	Alliance of Genome Resources
DOID:12336	male infertility	Alliance of Genome Resources
DOID:14227	azoospermia	Alliance of Genome Resources
DOID:2476	hereditary spastic paraplegia	Alliance of Genome Resources
DOID:811	lipodystrophy	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 87 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	14705	10090_1:00543e	MGI:1298392	MOUSE25857
Homo sapiens	26580		HGNC:15832	HUMAN06619
Drosophila melanogaster	31245		FB:FBgn0040336
Caenorhabditis elegans	259621		WB:WBGene00019808
Canis lupus familiaris	476054			CANLF06158
Bos taurus	513558			BOVIN23295
Danio rerio	541427		ZFIN:ZDB-GENE-050320-130
Danio rerio	567403		ZFIN:ZDB-GENE-051113-140
Monodelphis domestica	100012298			MONDO26975
Equus caballus	100063764			HORSE06227