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angiopoietin-like 4

Summary

Gene Symbol

Angptl4

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

362850

PubChem

362850

Alliance of Genome Resources

RGD:735058

Annotation

Keyword

Angiogenesis
Coiled coil
Disulfide bond
Extracellular matrix
Glycoprotein
Lipid metabolism
Reference proteome
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q6TMA8	Angiopoietin-like protein 4 Hepatic fibrinogen/angiopoietin-related protein
A6KQI0	Angiopoietin-like protein 4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
endothelial cell apoptotic process	ISO
lipid metabolic process	IEA
protein unfolding	ISO
negative regulation of lipoprotein lipase activity	IEA ISO TAS	14570927
response to hypoxia	IEP	17033689

GO Hierarchy

biological process

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process

organic substance metabolic process [inference]

lipid metabolic process

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

epithelial cell apoptotic process [inference]

endothelial cell apoptotic process

protein unfolding

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

acylglycerol homeostasis [inference]

triglyceride homeostasis

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of primary metabolic process [inference]

regulation of lipid metabolic process

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of epithelial cell apoptotic process [inference]

negative regulation of endothelial cell apoptotic process

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of epithelial cell apoptotic process [inference]

negative regulation of endothelial cell apoptotic process

regulation of epithelial cell apoptotic process [inference]

negative regulation of epithelial cell apoptotic process [inference]

negative regulation of endothelial cell apoptotic process

regulation of endothelial cell apoptotic process [inference]

negative regulation of endothelial cell apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of epithelial cell apoptotic process [inference]

negative regulation of endothelial cell apoptotic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of epithelial cell apoptotic process [inference]

negative regulation of endothelial cell apoptotic process

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity

negative regulation of hydrolase activity [inference]

negative regulation of lipase activity [inference]

negative regulation of lipoprotein lipase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity

negative regulation of hydrolase activity [inference]

negative regulation of lipase activity [inference]

negative regulation of lipoprotein lipase activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of lipase activity [inference]

negative regulation of lipoprotein lipase activity

regulation of lipase activity [inference]

regulation of lipoprotein lipase activity [inference]

negative regulation of lipoprotein lipase activity

negative regulation of lipase activity [inference]

negative regulation of lipoprotein lipase activity

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular space	IBA ISO
extracellular region	ISO
collagen-containing extracellular matrix	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

Displaying **all 2** entries
GO Term	Evidence Code	PMID
enzyme inhibitor activity	IBA ISO TAS	15863837
identical protein binding	IPI ISO	14570927 15863837

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

identical protein binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

angiopoietin-related protein 4

Functional Category

D: Cell cycle control, cell division, chromosome partitioning
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
lipid metabolic process
triglyceride homeostasis

Displaying **all 4** entries
InterPro
Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
Fibrinogen, conserved site
Fibrinogen-like, C-terminal

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:1574	alcohol use disorder	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **105** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	36411		FB:FBgn0003326
Homo sapiens	51129		HGNC:16039	HUMAN40378
Mus musculus	57875	10090_1:004d7a	MGI:1888999	MOUSE23012
Caenorhabditis elegans	177668		WB:WBGene00016769
Caenorhabditis elegans	177911		WB:WBGene00012782
Sus scrofa	397628			PIGXX18589
Canis lupus familiaris	476724			CANLF07937
Danio rerio	492647		ZFIN:ZDB-GENE-041111-222	DANRE28483
Bos taurus	509963			BOVIN32748
Macaca mulatta	711693			MACMU20390

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Acknowledgements