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inositol polyphosphate-5-phosphatase B

Summary

Gene Symbol

INPP5B

Aliases

type II inositol 1,4,5-trisphosphate 5-phosphatase

Organism

Homo sapiens (human)

External Links

NCBI Gene

3633

HGNC

6077

KEGG Gene ID

hsa:3633

PubChem

3633

Alliance of Genome Resources

HGNC:6077

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
Cytoplasmic vesicle
Direct protein sequencing
Endosome
Golgi apparatus
Hydrolase
Lipid metabolism
Magnesium
Membrane
Metal-binding
Methylation
Prenylation
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P32019	75 kDa inositol polyphosphate-5-phosphatase Phosphoinositide 5-phosphatase
B3KMW4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
spermatogenesis	IEA
regulation of protein processing	IEA
signal transduction	IEA
flagellated sperm motility	IEA
phosphatidylinositol dephosphorylation	IBA IDA	7721860

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

dephosphorylation [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

inositol phosphate metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

inositol phosphate metabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

inositol phosphate metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

inositol phosphate metabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

inositol phosphate metabolic process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

cilium movement [inference]

cilium movement involved in cell motility [inference]

flagellated sperm motility

signal transduction

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

dephosphorylation [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

inositol phosphate metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

inositol phosphate metabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

cell motility [inference]

cilium or flagellum-dependent cell motility [inference]

cilium-dependent cell motility [inference]

flagellated sperm motility

sperm motility [inference]

flagellated sperm motility

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

sperm motility [inference]

flagellated sperm motility

multicellular organismal process [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of protein maturation [inference]

regulation of protein processing

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of protein maturation [inference]

regulation of protein processing

regulation of nitrogen compound metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

regulation of protein processing

regulation of protein maturation [inference]

regulation of protein processing

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of protein maturation [inference]

regulation of protein processing

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

regulation of protein processing

regulation of protein maturation [inference]

regulation of protein processing

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

regulation of protein processing

regulation of protein maturation [inference]

regulation of protein processing

regulation of cellular process [inference]

signal transduction

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of protein maturation [inference]

regulation of protein processing

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GO Term	Evidence Code	PMID
endoplasmic reticulum-Golgi intermediate compartment	IEA
cytosol	IBA IDA	7721860
plasma membrane
phagocytic vesicle membrane	IEA
membrane	IBA IDA	7721860

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

early endosome membrane

endocytic vesicle membrane [inference]

phagocytic vesicle membrane

bounding membrane of organelle [inference]

endosome membrane [inference]

early endosome membrane

endocytic vesicle membrane [inference]

phagocytic vesicle membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying **all 5** entries
GO Term	Evidence Code	PMID
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
inositol-1,4,5-trisphosphate 5-phosphatase activity	IBA IDA TAS	7721860
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	IBA IDA	7721860
metal ion binding	IEA
protein binding	IPI	21233288 25869668

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

inositol phosphate phosphatase activity [inference]

inositol trisphosphate phosphatase activity [inference]

inositol-1,4,5-trisphosphate 5-phosphatase activity

inositol tetrakisphosphate phosphatase activity [inference]

inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity

phosphatidylinositol phosphate phosphatase activity [inference]

phosphatidylinositol bisphosphate phosphatase activity [inference]

phosphatidylinositol-4,5-bisphosphate phosphatase activity [inference]

phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity

phosphatidylinositol phosphate 5-phosphatase activity [inference]

phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000204084

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K01099

Name

inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]

References

Rhea

RHEA:22764

H₂O + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)

phosphate + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)

Enzyme

3.1.3.36

PMID

Disease

Disease Ontology

Displaying entries **31 - 40** of 53 in total

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DO ID	Disease Name	Source
DOID:0110298	autosomal recessive limb-girdle muscular dystrophy type 2N	DisGeNET
DOID:0110299	autosomal recessive limb-girdle muscular dystrophy type 2I	DisGeNET
DOID:0110300	obsolete autosomal dominant limb-girdle muscular dystrophy type 1A	DisGeNET
DOID:0110301	obsolete autosomal dominant limb-girdle muscular dystrophy type 1B	DisGeNET
DOID:0110302	obsolete autosomal dominant limb-girdle muscular dystrophy type 1C	DisGeNET
DOID:0110303	autosomal dominant limb-girdle muscular dystrophy type 1H	DisGeNET
DOID:0110304	autosomal dominant limb-girdle muscular dystrophy type 2	DisGeNET
DOID:0110305	autosomal dominant limb-girdle muscular dystrophy type 1	DisGeNET
DOID:0110306	autosomal dominant limb-girdle muscular dystrophy type 3	DisGeNET
DOID:0110980	Joubert syndrome 1	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000303
Gene Name: inositol polyphosphate-5-phosphatase, 75kDa

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	172822	WB:WBGene00007620
Drosophila melanogaster	31157	FB:FBgn0023508
Callorhinchus milii	103179631		CALMI18251
Danio rerio	563543	ZFIN:ZDB-GENE-110411-228	DANRE10342
Ictalurus punctatus	108269428		ICTPU14254
Electrophorus electricus	113578044		ELEEL22534
Esox lucius	105027176		ESOLU58773
Salmo trutta	115176668		SALTR43411
Salmo trutta	115177251		SALTR85445
Gadus morhua	115553425		GADMO04013

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements