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MIRAGE
insulin receptor substrate 1
Summary
- Gene Symbol
-
- IRS1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Diabetes mellitus
- Disease variant
- Phosphoprotein
- Reference proteome
- Repeat
- S-nitrosylation
- Transducer
- Ubl conjugation
- Proteins
| UniProt | Protein Name |
|---|---|
| P35568 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| cellular response to fatty acid | ||
| insulin receptor signaling pathway | ||
| positive regulation of fatty acid beta-oxidation | ||
| negative regulation of insulin secretion | ||
| signal transduction |
GO Hierarchy
biological process
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of signaling [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| transmembrane receptor protein tyrosine kinase adaptor activity | ||
| SH2 domain binding | ||
| signaling adaptor activity | ||
| signaling receptor complex adaptor activity | ||
| insulin-like growth factor receptor binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Insulin receptor substrate
- Functional Category
-
- E: Amino acid transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| insulin receptor binding |
| insulin receptor signaling pathway |
| phosphatidylinositol 3-kinase binding |
| InterPro |
|---|
| IRS-type PTB domain |
| Insulin receptor substrate |
| PH-like domain superfamily |
| Pleckstrin homology domain |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080208 | metabolic dysfunction-associated steatotic liver disease | |
| DOID:1059 | intellectual disability | |
| DOID:10652 | Alzheimer's disease | |
| DOID:10914 | amnestic disorder | |
| DOID:11476 | osteoporosis | |
| DOID:13223 | uterine fibroid | |
| DOID:3393 | coronary artery disease | |
| DOID:4194 | glucose metabolism disease | |
| DOID:783 | end stage renal disease | |
| DOID:9352 | type 2 diabetes mellitus |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 16367 | MGI:99454 | MOUSE27536 | ||
| 25467 | RGD:2922 | RATNO43031 | ||
| 64880 | FB:FBgn0024248 | |||
| 394823 | Xenbase:XB-GENE-6455904 | |||
| 399299 | Xenbase:XB-GENE-478676 | |||
| 459985 | 9598_0:000d44 | PANTR29913 | ||
| 538598 | BOVIN24846 | |||
| 559281 | ZFIN:ZDB-GENE-030131-872 | DANRE09359 | ||
| 707870 | MACMU06003 | |||
| 100021838 | MONDO32632 |
