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Glycomics MS Repository for glycan annotations from GlycoWorkbench
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Repository for lectin-assisted multimodality data
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Guidelines
MIRAGE
insulin receptor substrate 1
Summary
- Gene Symbol
-
- IRS1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Cytoplasm
- Diabetes mellitus
- Disease variant
- Isopeptide bond
- Nucleus
- Phosphoprotein
- Proteomics identification
- Reference proteome
- Repeat
- S-nitrosylation
- Transducer
- Ubl conjugation
- Proteins
| UniProt | Protein Name |
|---|---|
| P35568 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| signal transduction | ||
| positive regulation of cell population proliferation | ||
| insulin receptor signaling pathway | ||
| insulin receptor signaling pathway | ||
| insulin receptor signaling pathway |
GO Hierarchy
biological process
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of signaling [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| phosphotyrosine residue binding | ||
| transmembrane receptor protein tyrosine kinase adaptor activity | ||
| protein kinase C binding | ||
| insulin receptor binding | ||
| insulin receptor binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Insulin receptor substrate
- Functional Category
-
- O: Posttranslational modification, protein turnover, chaperones
- Q: Secondary metabolites biosynthesis, transport and catabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| insulin receptor binding |
| insulin receptor signaling pathway |
| phosphatidylinositol 3-kinase binding |
| InterPro |
|---|
| IRS-type PTB domain |
| Insulin receptor substrate |
| PH-like domain superfamily |
| Pleckstrin homology domain |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:10652 | Alzheimer's disease | |
| DOID:13223 | uterine fibroid | |
| DOID:3393 | coronary artery disease | |
| DOID:9352 | type 2 diabetes mellitus |
