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four-jointed

Summary

Gene Symbol

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

37089

PubChem

37089

Alliance of Genome Resources

FB:FBgn0000658

Annotation

Keyword

Glycoprotein
Golgi apparatus
Notch signaling pathway
Reference proteome
Secreted
Serine/threonine-protein kinase
Signal-anchor
Transmembrane helix
Wnt signaling pathway

Proteins

Displaying 1 entry
UniProt	Protein Name
P54360

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
regulation of tube length, open tracheal system	IMP	19956736
protein phosphorylation	IDA	20434335
establishment of imaginal disc-derived wing hair orientation	IMP	21379328
Notch signaling pathway
establishment of ommatidial planar polarity	IMP	15548581

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular process [inference]

cell communication [inference]

cell-cell signaling

establishment or maintenance of cell polarity [inference]

establishment of ommatidial planar polarity

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

imaginal disc-derived wing vein specification

developmental process [inference]

anatomical structure morphogenesis [inference]

establishment of tissue polarity [inference]

establishment of planar polarity

post-embryonic animal morphogenesis [inference]

growth [inference]

developmental growth [inference]

imaginal disc growth

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of animal organ morphogenesis [inference]

regulation of establishment of planar polarity

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

regulation of biological quality [inference]

regulation of tube architecture, open tracheal system [inference]

regulation of tube size, open tracheal system [inference]

regulation of tube length, open tracheal system

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube size, open tracheal system [inference]

regulation of tube length, open tracheal system

regulation of molecular function [inference]

regulation of binding [inference]

regulation of protein binding

Displaying **all 4** entries
GO Term	Evidence Code	PMID
plasma membrane	IDA	7555705
Golgi membrane
extracellular space	IBA
cytoplasm	HDA	26896675

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein serine kinase activity
protein serine/threonine kinase activity	IDA	18635802
Wnt-protein binding	IPI	15986451

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

binding [inference]

protein binding [inference]

Wnt-protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Protein four-jointed

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
cell-cell signaling

Displaying 1 entry
InterPro
Four-jointed box protein 1/four-jointed protein

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
plasma membrane	PMID:7555705
cytoplasm	PMID:26896675

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:9970	obesity	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 43 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Mus musculus	14221		MGI:1341907
Homo sapiens	24147		HGNC:17166
Rattus norvegicus	366140		RGD:1306113
Drosophila pseudoobscura	4804788	7237_0:00349e
Drosophila ananassae	6495004	7217_1:001ae1
Drosophila yakuba	6531120	7245_0:002fb0
Drosophila erecta	6547054	7220_1:002944
Drosophila grimshawi	6560342	7222_1:00090f
Drosophila mojavensis	6578898	7230_1:002dcd
Drosophila persimilis	6592864	7234_1:001156

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements