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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
inositol 1,4,5-trisphosphate receptor type 3
Summary
- Gene Symbol
-
- ITPR3
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Calcium channel
- Charcot-Marie-Tooth disease
- Coiled coil
- Cytoplasmic vesicle
- Disease variant
- Disulfide bond
- Endoplasmic reticulum
- Ligand-gated ion channel
- Membrane
- Neurodegeneration
- Phosphoprotein
- Receptor
- Reference proteome
- Repeat
- Transmembrane helix
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| sensory perception of taste | ||
| response to calcium ion | ||
| calcium ion homeostasis | ||
| calcium-mediated signaling | ||
| memory |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| secretory granule membrane | ||
| membrane | ||
| transport vesicle membrane | ||
| receptor complex | ||
| endoplasmic reticulum membrane |
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| inositol hexakisphosphate binding | ||
| inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity | ||
| phosphatidylinositol binding | ||
| inositol 1,3,4,5 tetrakisphosphate binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- inositol 1,4,5-trisphosphate receptor
- Functional Category
-
- E: Amino acid transport and metabolism
- J: Translation, ribosomal structure and biogenesis
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| InterPro |
|---|
| Inositol 1,4,5-trisphosphate receptor |
| MIR motif |
| RIH domain |
| Ryanodine/Inositol 1,4,5-trisphosphate receptor |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060041 | autism spectrum disorder | |
| DOID:10591 | pre-eclampsia | |
| DOID:10595 | Charcot-Marie-Tooth disease | |
| DOID:11714 | gestational diabetes | |
| DOID:1441 | autosomal dominant cerebellar ataxia | |
| DOID:9744 | type 1 diabetes mellitus | |
| DOID:9970 | obesity |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 16440 | MGI:96624 | MOUSE21895 | ||
| 25679 | RGD:2934 | RATNO22044 | ||
| 40664 | FB:FBgn0010051 | |||
| 177546 | WB:WBGene00002173 | |||
| 281879 | BOVIN18302 | |||
| 462618 | 9598_0:001d07 | PANTR37920 | ||
| 481746 | CANLF02641 | |||
| 718040 | MACMU34185 | |||
| 794666 | ZFIN:ZDB-GENE-070605-1 | DANRE43485 | ||
| 100025596 | MONDO13468 |
