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involucrin

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

3713

PubChem

3713

Alliance of Genome Resources

HGNC:6187

Annotation

Keyword

Cytoplasm
Direct protein sequencing
Isopeptide bond
Keratinization
Lipoprotein
Reference proteome
Repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
P07476

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine	TAS	1601889
peptide cross-linking	IDA	10908733
keratinization	IEA
keratinocyte differentiation	IDA	10908733
response to UV-B	IDA	16639001

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptide cross-linking

isopeptide cross-linking [inference]

isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine

peptidyl-amino acid modification [inference]

peptidyl-glutamine modification [inference]

isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine

peptidyl-lysine modification [inference]

isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptide cross-linking

isopeptide cross-linking [inference]

isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine

peptidyl-amino acid modification [inference]

peptidyl-glutamine modification [inference]

isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine

peptidyl-lysine modification [inference]

isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptide cross-linking

isopeptide cross-linking [inference]

isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine

peptidyl-amino acid modification [inference]

peptidyl-glutamine modification [inference]

isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine

peptidyl-lysine modification [inference]

isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine

macromolecule modification [inference]

protein modification process [inference]

peptide cross-linking

isopeptide cross-linking [inference]

isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine

peptidyl-amino acid modification [inference]

peptidyl-glutamine modification [inference]

isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine

peptidyl-lysine modification [inference]

isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptide cross-linking

isopeptide cross-linking [inference]

isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine

peptidyl-amino acid modification [inference]

peptidyl-glutamine modification [inference]

isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine

peptidyl-lysine modification [inference]

isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine

cellular process [inference]

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

epidermal cell differentiation [inference]

keratinocyte differentiation

multicellular organismal process [inference]

keratinization

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

epidermal cell differentiation [inference]

keratinocyte differentiation

response to stimulus [inference]

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

response to UV [inference]

response to UV-B

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
cornified envelope	IDA TAS	10908733
nuclear body	IDA
centrosome	IDA
cytosol	IDA TAS
cytoplasm	IDA	16639001

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

microtubule organizing center [inference]

centrosome

cytosol

membrane [inference]

plasma membrane [inference]

cornified envelope

nuclear body

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying 1 entry
GO Term	Evidence Code	PMID
protein binding	IPI	21044950

GO Hierarchy

molecular function

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

involucrin

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
keratinization
keratinocyte differentiation

Displaying 1 entry
InterPro
Involucrin, N-terminal

Ortholog

Displaying entries **1 - 10** of 11 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	16447		MGI:96626	MOUSE39415
Rattus norvegicus	60583		RGD:620141
Pan troglodytes	736637	9598_0:000128		PANTR22312
Pongo abelii	100459449	9601_0:00009a		PONAB19103
Nomascus leucogenys	100579888			NOMLE05967
Cricetulus griseus	100761237			CRIGR25445
Pan paniscus	100972032	9597_0:00074d		PANPA02486
Gorilla gorilla gorilla	101125010	9595_0:0003a7
Carlito syrichta	103276673			CARSF00075
Cebus imitator	108292401			CEBIM30872

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements