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Janus kinase 1

Summary

Gene Symbol

JAK1

Organism

Homo sapiens (human)

External Links

NCBI Gene

3716

PubChem

3716

Alliance of Genome Resources

HGNC:6190

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Disease variant
Magnesium
Membrane
Metal-binding
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
SH2 domain
Tyrosine-protein kinase
Ubl conjugation

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q6P669
A0A8V8TPQ9
P23458	Janus kinase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 36 in total

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GO Term	Evidence Code	PMID
protein phosphorylation	IMP	28111307 32750333
receptor signaling pathway via JAK-STAT	NAS	12574355
receptor signaling pathway via JAK-STAT	TAS	8232552
receptor signaling pathway via JAK-STAT	IDA	7657660 8232552 8272873
receptor signaling pathway via JAK-STAT	IMP	28111307 32750333

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

growth hormone receptor signaling pathway [inference]

growth hormone receptor signaling pathway via JAK-STAT

cytokine-mediated signaling pathway

interferon-mediated signaling pathway [inference]

receptor signaling pathway via STAT [inference]

receptor signaling pathway via JAK-STAT

intracellular signal transduction

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

cellular developmental process [inference]

cell differentiation

cell fate commitment [inference]

T cell lineage commitment [inference]

alpha-beta T cell lineage commitment [inference]

CD4-positive, alpha-beta T cell lineage commitment [inference]

T-helper cell lineage commitment [inference]

T-helper 17 cell lineage commitment

CD4-positive or CD8-positive, alpha-beta T cell lineage commitment [inference]

CD4-positive, alpha-beta T cell lineage commitment [inference]

T-helper cell lineage commitment [inference]

T-helper 17 cell lineage commitment

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell junction [inference]

protein localization to cell-cell junction

developmental process [inference]

cellular developmental process [inference]

cell differentiation

cell fate commitment [inference]

T cell lineage commitment [inference]

alpha-beta T cell lineage commitment [inference]

CD4-positive, alpha-beta T cell lineage commitment [inference]

T-helper cell lineage commitment [inference]

T-helper 17 cell lineage commitment

CD4-positive or CD8-positive, alpha-beta T cell lineage commitment [inference]

CD4-positive, alpha-beta T cell lineage commitment [inference]

T-helper cell lineage commitment [inference]

T-helper 17 cell lineage commitment

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus [inference]

cellular response to virus

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

cellular response to virus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

cellular response to virus

response to chemical [inference]

response to antibiotic

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell junction [inference]

protein localization to cell-cell junction

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell junction [inference]

protein localization to cell-cell junction

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to nucleus [inference]

positive regulation of protein localization to nucleus

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of homotypic cell-cell adhesion

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of sprouting angiogenesis [inference]

positive regulation of sprouting angiogenesis

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of sprouting angiogenesis [inference]

positive regulation of sprouting angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

growth hormone receptor signaling pathway [inference]

growth hormone receptor signaling pathway via JAK-STAT

cytokine-mediated signaling pathway

interferon-mediated signaling pathway [inference]

receptor signaling pathway via STAT [inference]

receptor signaling pathway via JAK-STAT

intracellular signal transduction

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of homotypic cell-cell adhesion

regulation of homotypic cell-cell adhesion [inference]

positive regulation of homotypic cell-cell adhesion

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of homotypic cell-cell adhesion

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of homotypic cell-cell adhesion

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to nucleus [inference]

positive regulation of protein localization to nucleus

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of sprouting angiogenesis [inference]

positive regulation of sprouting angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
nucleus	IDA	10502458
cytoplasm	IC	7532278
cytoplasm	IDA	10502458
endosome	TAS
cytosol	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

extrinsic component of membrane [inference]

extrinsic component of plasma membrane [inference]

extrinsic component of cytoplasmic side of plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of plasma membrane

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GO Term	Evidence Code	PMID
protein tyrosine kinase activity	EXP	10825200 1386289 31892268 9446616
protein tyrosine kinase activity	TAS
protein tyrosine kinase activity	IC	7543512
protein tyrosine kinase activity	IDA	10702271 15226449 7532278 7929391 7973659 8272873 8756628
non-membrane spanning protein tyrosine kinase activity	TAS	34813358 8232552

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein tyrosine kinase activity

histone kinase activity [inference]

histone H3 kinase activity [inference]

histone H3Y41 kinase activity

histone H2AX kinase activity [inference]

histone H2AXY142 kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein tyrosine kinase activity

histone kinase activity [inference]

histone H3 kinase activity [inference]

histone H3Y41 kinase activity

histone H2AX kinase activity [inference]

histone H2AXY142 kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein tyrosine kinase activity

histone kinase activity [inference]

histone H3 kinase activity [inference]

histone H3Y41 kinase activity

histone H2AX kinase activity [inference]

histone H2AXY142 kinase activity

histone modifying activity [inference]

histone kinase activity [inference]

histone H3 kinase activity [inference]

histone H3Y41 kinase activity

histone H2AX kinase activity [inference]

histone H2AXY142 kinase activity

binding [inference]

protein binding

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

chemokine receptor binding [inference]

CCR chemokine receptor binding [inference]

CCR5 chemokine receptor binding

cytokine receptor binding [inference]

growth hormone receptor binding

chemokine receptor binding [inference]

CCR chemokine receptor binding [inference]

CCR5 chemokine receptor binding

hormone receptor binding [inference]

growth hormone receptor binding

enzyme binding [inference]

phosphatase binding [inference]

protein phosphatase binding

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

protein kinase

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 10** entries
Gene Ontology
ATP binding
cell differentiation
cytokine-mediated signaling pathway
growth hormone receptor binding
growth hormone receptor signaling pathway via JAK-STAT
kinase activity
non-membrane spanning protein tyrosine kinase activity
nucleotide binding
phosphorylation
transferase activity

Displaying **all 3** entries
InterPro
Protein kinase domain
Protein kinase-like domain superfamily
Serine-threonine/tyrosine-protein kinase, catalytic domain

Disease

Disease Ontology

Displaying **all 9** entries
DO ID	Disease Name	Source
DOID:10283	prostate cancer	Alliance of Genome Resources
DOID:10534	stomach cancer	Alliance of Genome Resources
DOID:1380	endometrial cancer	Alliance of Genome Resources
DOID:2394	ovarian cancer	Alliance of Genome Resources
DOID:3908	lung non-small cell carcinoma	Alliance of Genome Resources
DOID:4074	pancreatic adenocarcinoma	Alliance of Genome Resources
DOID:5603	T-cell acute lymphoblastic leukemia	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources
DOID:9256	colorectal cancer	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 86 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	3716	Xenbase:XB-GENE-483750
Drosophila melanogaster	3718	FB:FBgn0004864
Drosophila melanogaster	7297	FB:FBgn0004864
Mus musculus	16451		MOUSE41662
Danio rerio	30280		DANRE38336
Rattus norvegicus	84598		RATNO33650
Sus scrofa	397202		PIGXX30216
Canis lupus familiaris	442952		CANLF15631
Bos taurus	537201		BOVIN26794
Macaca mulatta	677689		MACMU25610

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OrthoDB (Group)

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Acknowledgements