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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
potassium voltage-gated channel subfamily A member 2
Summary
- Gene Symbol
-
- KCNA2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- Alternative splicing
- Cell junction
- Cell membrane
- Cell projection
- Disease variant
- Endoplasmic reticulum
- Epilepsy
- Glycoprotein
- Palmitate
- Phosphoprotein
- Potassium channel
- Reference proteome
- Synaptosome
- Transmembrane helix
- Voltage-gated channel
- Proteins
| UniProt | Protein Name |
|---|---|
| P16389 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| optic nerve structural organization | ||
| regulation of postsynaptic membrane potential | ||
| potassium ion export across plasma membrane | ||
| action potential | ||
| sensory perception of pain |
| GO Term | Evidence Code | PMID |
|---|---|---|
| voltage-gated potassium channel complex | ||
| axon terminus | ||
| membrane | ||
| postsynaptic membrane | ||
| juxtaparanode region of axon |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| delayed rectifier potassium channel activity | ||
| kinesin binding | ||
| voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential | ||
| voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential |
GO Hierarchy
molecular function
transporter activity [inference]
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Potassium channel
- Functional Category
-
- E: Amino acid transport and metabolism
- K: Transcription
- P: Inorganic ion transport and metabolism
- T: Signal transduction mechanisms
| InterPro |
|---|
| Ion transport domain |
| Potassium channel tetramerisation-type BTB domain |
| Voltage-dependent channel domain superfamily |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050989 | episodic ataxia type 1 | |
| DOID:0080416 | developmental and epileptic encephalopathy 32 | |
| DOID:1826 | epilepsy |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 16490 | MGI:96659 | MOUSE38887 | ||
| 25468 | RGD:2950 | RATNO23419 | ||
| 32780 | FB:FBgn0003380 | |||
| 174536 | WB:WBGene00014261 | |||
| 373840 | Xenbase:XB-GENE-991585 | |||
| 397292 | PIGXX24491 | |||
| 404022 | CANLF16803 | |||
| 469413 | 9598_0:000892 | |||
| 539608 | BOVIN26296 | |||
| 562853 | ZFIN:ZDB-GENE-080204-89 | DANRE25341 |
