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MIRAGE
potassium calcium-activated channel subfamily N member 4
Summary
- Gene Symbol
-
- KCNN4
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Calmodulin-binding
- Cell membrane
- Disease variant
- Hereditary hemolytic anemia
- Immunity
- Ion channel
- Phosphoprotein
- Reference proteome
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| O15554 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| immune system process | ||
| potassium ion transport | ||
| calcium ion transport | ||
| cell volume homeostasis | ||
| defense response |
GO Hierarchy
- immune system process
biological process
cellular process [inference]
localization [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| cytosol | ||
| plasma membrane | ||
| plasma membrane | ||
| plasma membrane | ||
| voltage-gated potassium channel complex |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| potassium channel activity | ||
| protein binding | ||
| calmodulin binding | ||
| calmodulin binding | ||
| calcium-activated potassium channel activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- small conductance calcium-activated potassium channel
- Functional Category
-
- E: Amino acid transport and metabolism
- H: Coenzyme transport and metabolism
- P: Inorganic ion transport and metabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| calcium-activated potassium channel activity |
| calmodulin binding |
| monoatomic ion transport |
| small conductance calcium-activated potassium channel activity |
| InterPro |
|---|
| Calmodulin-binding domain |
| Potassium channel domain |
| Potassium channel, calcium-activated, SK |
| SK, calmodulin-binding domain superfamily |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0001816 | angiosarcoma | |
| DOID:0111577 | dehydrated hereditary stomatocytosis 2 | |
| DOID:3526 | cerebral infarction | |
| DOID:5844 | myocardial infarction |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 3783 | Xenbase:XB-GENE-1013002 | ||
| 16534 | MOUSE54463 | ||
| 65206 | RATNO15982 | ||
| 397081 | PIGXX27995 | ||
| 456098 | PANTR18533 | ||
| 484464 | CANLF00975 | ||
| 568363 | DANRE10103 | ||
| 712383 | MACMU19492 | ||
| 100093560 | ORNAN22773 | ||
| 100379254 | CAVPO20362 |
