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ketohexokinase

Summary

Gene Symbol

KHK

Aliases

fructokinase

Organism

Homo sapiens (human)

External Links

NCBI Gene

3795

HGNC

6315

KEGG Gene ID

hsa:3795

PubChem

3795

Alliance of Genome Resources

HGNC:6315

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Carbohydrate metabolism
Disease variant
Kinase
Proteomics identification
Reference proteome

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A140VJM6
C9JDL1
P50053	Hepatic fructokinase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
regulation of glycogen metabolic process	IBA
fructose metabolic process	IBA IEA
response to zinc ion	IBA
response to fructose	IBA
response to insulin	IBA

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

carbohydrate phosphorylation

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process

carbohydrate phosphorylation

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process

carbohydrate phosphorylation

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

carbohydrate phosphorylation

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to disaccharide [inference]

response to sucrose

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to inorganic substance [inference]

response to metal ion [inference]

response to zinc ion

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to oxygen-containing compound [inference]

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to disaccharide [inference]

response to sucrose

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of cellular metabolic process [inference]

regulation of generation of precursor metabolites and energy [inference]

regulation of glycogen metabolic process

regulation of macromolecule metabolic process [inference]

regulation of polysaccharide metabolic process [inference]

regulation of glycogen metabolic process

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of polysaccharide metabolic process [inference]

regulation of glycogen metabolic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of generation of precursor metabolites and energy [inference]

regulation of glycogen metabolic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytosol	TAS
cytoplasm	IBA IDA
extracellular exosome	HDA	19056867

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
ketohexokinase activity	IBA IDA	12941785
ATP binding	IEA
protein binding	IPI	25416956

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

carbohydrate kinase activity [inference]

ketohexokinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

ketohexokinase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000138030

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00846

Name

ketohexokinase [EC:2.7.1.3]

References

19158351

Rhea

β-D-fructose + ATP

β-D-fructose 1-phosphate + H⁺ + ADP

Enzyme

2.7.1.3

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 28 in total

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DO ID	Disease Name	Source
DOID:0014667	disease of metabolism	DisGeNET
DOID:0050387	nonpapillary renal cell carcinoma	DisGeNET
DOID:0111680	essential fructosuria	Alliance of Genome Resources
DOID:114	heart disease	DisGeNET
DOID:1287	cardiovascular system disease	DisGeNET
DOID:1324	lung cancer	DisGeNET
DOID:162	cancer	DisGeNET DisGeNET DisGeNET
DOID:1920	hyperuricemia	DisGeNET
DOID:3070	high grade glioma	DisGeNET DisGeNET
DOID:3071	gliosarcoma	DisGeNET DisGeNET

The Human Phenotype Ontology

Displaying **all 5** entries
HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0003074	Hyperglycemia
HP:0010969	Abnormality of glycolipid metabolism
HP:0011033	Impairment of fructose metabolism
HP:0012379	Abnormal circulating enzyme concentration or activity

Displaying **all 2** entries
Disease ID	Disease Name
OMIM:229800	essential fructosuria
ORPHA:2056	essential fructosuria

PubChem Disease

MedGen Diseases

Essential fructosuria

OMIM Phenotypes

FRUCTOSURIA, ESSENTIAL

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **1 - 10** of 79 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	39279	FB:FBgn0036160
Drosophila melanogaster	39280	FB:FBgn0036161
Drosophila melanogaster	40203	FB:FBgn0036941
Drosophila melanogaster	40204	FB:FBgn0036942
Callorhinchus milii	103184052		CALMI03264
Danio rerio	436909	ZFIN:ZDB-GENE-040718-381	DANRE12293
Ictalurus punctatus	108269966		ICTPU34991
Electrophorus electricus	113571086		ELEEL09348
Salmo salar	100306748		SALSA07078
Salmo trutta	115172940		SALTR71826

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GlyCosmos Portal v4.0.0

Last updated: August 19, 2024