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C-X-C motif chemokine receptor 4 S homeolog

Summary

Gene Symbol

cxcr4.S

Organism

Xenopus laevis (African clawed frog)

External Links

NCBI Gene

380373

PubChem

380373

Alliance of Genome Resources

Xenbase:XB-GENE-6256540

Annotation

Keyword

Cell membrane
Cytoplasm
Disulfide bond
Endosome
G-protein coupled receptor
Gastrulation
Glycoprotein
Lysosome
Nucleus
Reference proteome
Sulfation
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A974BUH0
Q7ZXJ7	Stromal cell-derived factor 1 receptor B

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 14 in total

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GO Term	Evidence Code	PMID
cellular response to cytokine stimulus	ISS
definitive hemopoiesis	ISS
chemokine-mediated signaling pathway	IEA
mesoderm migration involved in gastrulation	ISS
gastrulation	IEA

GO Hierarchy

biological process

immune system process [inference]

immune response

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

chemokine-mediated signaling pathway

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

cellular process involved in reproduction in multicellular organism [inference]

germ cell migration

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

cell development [inference]

hemopoiesis [inference]

definitive hemopoiesis

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

mesodermal cell migration [inference]

mesoderm migration involved in gastrulation

cell migration involved in gastrulation [inference]

mesoderm migration involved in gastrulation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus

reproductive process [inference]

cellular process involved in reproduction in multicellular organism [inference]

germ cell migration

multicellular organismal process [inference]

tissue migration [inference]

mesoderm migration involved in gastrulation

developmental process [inference]

anatomical structure morphogenesis [inference]

embryonic morphogenesis [inference]

gastrulation

anatomical structure development [inference]

cell development [inference]

hemopoiesis [inference]

definitive hemopoiesis

animal organ development [inference]

brain development

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

cell development [inference]

hemopoiesis [inference]

definitive hemopoiesis

locomotion [inference]

taxis [inference]

chemotaxis

cell chemotaxis

response to stimulus [inference]

immune response

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

cellular response to cytokine stimulus

cellular response to organic substance [inference]

cellular response to cytokine stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

chemokine-mediated signaling pathway

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
external side of plasma membrane	IEA
membrane	IEA
early endosome	IEA ISS
late endosome	IEA ISS
plasma membrane	IEA ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

nucleus

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
chemokine receptor activity	IEA
C-X-C chemokine receptor activity	ISS
C-C chemokine receptor activity	IEA
G protein-coupled receptor activity	IEA
C-C chemokine binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cytokine binding

chemokine binding [inference]

C-C chemokine binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity [inference]

chemokine receptor activity

G protein-coupled receptor activity

G protein-coupled chemoattractant receptor activity [inference]

chemokine receptor activity

immune receptor activity [inference]

cytokine receptor activity [inference]

chemokine receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

receptor

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

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Gene Ontology
C-C chemokine binding
C-C chemokine receptor activity
brain development
calcium-mediated signaling
cell chemotaxis
chemokine receptor activity
chemokine-mediated signaling pathway
chemotaxis
immune response
neurogenesis

Displaying **all 5** entries
InterPro
CXC chemokine receptor 4 N-terminal domain
CXC chemokine receptor 4/atypical chemokine receptor 2
Chemokine receptor family
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying entries **21 - 27** of 27 in total

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DO ID	Disease Name	Source
DOID:5603	T-cell acute lymphoblastic leukemia	Alliance of Genome Resources
DOID:615	leukopenia	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources
DOID:8577	ulcerative colitis	Alliance of Genome Resources
DOID:9119	acute myeloid leukemia	Alliance of Genome Resources
DOID:9256	colorectal cancer	Alliance of Genome Resources
DOID:9261	nasopharynx carcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **121 - 130** of **194** in total

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Species	Gene ID	OrthoDB
Cyanistes caeruleus	111931764	156563_0:001b09
Desmodus rotundus	112313099	9430_0:000af3
Nothoprocta perdicaria	112948630	30464_0:001b1b
Apteryx rowi	112977106	308060_0:0037ff
Dromaius novaehollandiae	112988309	8790_0:00224c
Dromaius novaehollandiae	112997455	8790_0:00066c
Pseudonaja textilis	113445468	8673_0:002e36
Athene cunicularia	113482188	194338_0:001aef
Zalophus californianus	113919282	9704_0:001086
Vombatus ursinus	114023167	29139_0:003ffd

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements