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neurofilament, heavy polypeptide

Summary

Gene Symbol

Nefh

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

380684

PubChem

380684

Alliance of Genome Resources

MGI:97309

Annotation

Keyword

Cell projection
Coiled coil
Cytoskeleton
Direct protein sequencing
Intermediate filament
Phosphoprotein
Reference proteome
Repeat

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q80TQ3
P19246	200 kDa neurofilament protein Neurofilament triplet H protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
microtubule cytoskeleton organization	IGI	10461886
ovarian follicle atresia	ISO
axon regeneration	ISO
neurofilament bundle assembly	ISO
neurofilament bundle assembly	IEA

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization

intermediate filament-based process [inference]

intermediate filament cytoskeleton organization

intermediate filament organization [inference]

intermediate filament bundle assembly

neurofilament bundle assembly

cellular response to stimulus [inference]

cellular response to stress [inference]

neuron projection regeneration [inference]

axon regeneration

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization

intermediate filament cytoskeleton organization

intermediate filament organization [inference]

intermediate filament bundle assembly

neurofilament bundle assembly

postsynaptic cytoskeleton organization [inference]

postsynaptic intermediate filament cytoskeleton organization

cellular component assembly [inference]

intermediate filament bundle assembly

neurofilament bundle assembly

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis [inference]

peripheral nervous system neuron axonogenesis

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection regeneration [inference]

axon regeneration

axon development

axon regeneration

supramolecular fiber organization [inference]

intermediate filament organization [inference]

intermediate filament bundle assembly

neurofilament bundle assembly

reproductive process [inference]

developmental process involved in reproduction [inference]

ovarian follicle atresia

developmental process [inference]

developmental process involved in reproduction [inference]

ovarian follicle atresia

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis [inference]

peripheral nervous system neuron axonogenesis

anatomical structure development [inference]

regeneration [inference]

neuron projection regeneration [inference]

axon regeneration

response to stimulus [inference]

response to stress [inference]

response to wounding [inference]

response to axon injury [inference]

axon regeneration

cellular response to stress [inference]

neuron projection regeneration [inference]

axon regeneration

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

response to leukemia inhibitory factor [inference]

cellular response to leukemia inhibitory factor

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

response to inorganic substance [inference]

response to sodium arsenite

response to arsenic-containing substance [inference]

response to sodium arsenite

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

response to salt [inference]

response to sodium arsenite

cellular response to stimulus [inference]

cellular response to stress [inference]

neuron projection regeneration [inference]

axon regeneration

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

postsynaptic modulation of chemical synaptic transmission

regulation of localization [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

regulation of organelle transport along microtubule

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

regulation of organelle transport along microtubule

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

postsynaptic modulation of chemical synaptic transmission

regulation of microtubule-based process [inference]

regulation of microtubule-based movement [inference]

regulation of organelle transport along microtubule

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

regulation of organelle transport along microtubule

Displaying entries **11 - 15** of 20 in total

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GO Term	Evidence Code	PMID
neuronal cell body	ISO
perikaryon	ISO
myelin sheath	HDA	17634366
neurofibrillary tangle	ISO
neurofibrillary tangle	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

intracellular anatomical structure [inference]

inclusion body [inference]

neurofibrillary tangle

cytoplasm

cell junction [inference]

synapse [inference]

Schaffer collateral - CA1 synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

dendrite [inference]

apical dendrite

basal dendrite [inference]

basal proximal dendrite

proximal dendrite [inference]

basal proximal dendrite

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intermediate filament cytoskeleton [inference]

postsynaptic intermediate filament cytoskeleton

postsynaptic cytoskeleton [inference]

postsynaptic intermediate filament cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intermediate filament cytoskeleton [inference]

postsynaptic intermediate filament cytoskeleton

postsynaptic cytoskeleton [inference]

postsynaptic intermediate filament cytoskeleton

postsynaptic specialization [inference]

postsynaptic density

cell body [inference]

neuronal cell body

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

intermediate filament

neurofilament

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
structural constituent of cytoskeleton	ISO
toxic substance binding	ISO
protein kinase binding	ISO
protein kinase binding	IEA
protein-macromolecule adaptor activity	ISO

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of cytoskeleton

structural constituent of postsynaptic intermediate filament cytoskeleton

structural constituent of synapse [inference]

structural constituent of postsynapse [inference]

structural constituent of postsynaptic intermediate filament cytoskeleton

binding [inference]

protein binding [inference]

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Keratin

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
intermediate filament organization

Displaying 1 entry
InterPro
Intermediate filament, rod domain

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	4744	Xenbase:XB-GENE-920068	HUMAN59830
Rattus norvegicus	24587		RATNO08824
Xenopus tropicalis	380684	Xenbase:XB-GENE-920068
Canis lupus familiaris	442940		CANLF10459
Pan troglodytes	458741		PANTR26285
Bos taurus	528842		BOVIN09794
Macaca mulatta	717705		MACMU01057
Monodelphis domestica	100030735		MONDO19554
Equus caballus	100064328		HORSE41341
Oryctolagus cuniculus	100357177		RABIT14771