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killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1

Summary

Gene Symbol

KIR3DL1

Organism

Homo sapiens (human)

External Links

NCBI Gene

3811

PubChem

3811

Alliance of Genome Resources

HGNC:6338

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disulfide bond
Glycoprotein
Immunoglobulin domain
Proteomics identification
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q5UCE2
Q6H2G3
Q8N6C9
P43629	CD158 antigen-like family member E HLA-BW4-specific inhibitory NK cell receptor Natural killer-associated transcript 3 p70 natural killer cell receptor clones CL-2/CL-11

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
natural killer cell mediated cytotoxicity	IMP	18502829
immune response	NAS	7716543 8662091
immune response-regulating signaling pathway	IBA

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity [inference]

leukocyte mediated cytotoxicity [inference]

natural killer cell mediated cytotoxicity

lymphocyte mediated immunity [inference]

natural killer cell mediated immunity [inference]

natural killer cell mediated cytotoxicity

immune response

innate immune response [inference]

natural killer cell mediated immunity [inference]

natural killer cell mediated cytotoxicity

cellular process [inference]

cell killing [inference]

leukocyte mediated cytotoxicity [inference]

natural killer cell mediated cytotoxicity

signal transduction [inference]

immune response-regulating signaling pathway

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

natural killer cell mediated immunity [inference]

natural killer cell mediated cytotoxicity

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response [inference]

natural killer cell mediated immunity [inference]

natural killer cell mediated cytotoxicity

immune response

innate immune response [inference]

natural killer cell mediated immunity [inference]

natural killer cell mediated cytotoxicity

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

natural killer cell mediated immunity [inference]

natural killer cell mediated cytotoxicity

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

natural killer cell mediated immunity [inference]

natural killer cell mediated cytotoxicity

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of immune response [inference]

immune response-regulating signaling pathway

regulation of response to stimulus [inference]

regulation of immune response [inference]

immune response-regulating signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

immune response-regulating signaling pathway

Displaying 1 entry
GO Term	Evidence Code	PMID
plasma membrane	IBA NAS TAS	7716543 8662091

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	27455421 27649529 28514442 32296183 33961781
HLA-B specific inhibitory MHC class I receptor activity	NAS	7650366
molecular adaptor activity	EXP	30773397
amyloid-beta binding	IDA	24052308

GO Hierarchy

molecular function

binding [inference]

protein binding

amide binding [inference]

peptide binding [inference]

amyloid-beta binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

MHC class I receptor activity [inference]

inhibitory MHC class I receptor activity [inference]

HLA-B specific inhibitory MHC class I receptor activity

immune receptor activity [inference]

MHC class I receptor activity [inference]

inhibitory MHC class I receptor activity [inference]

HLA-B specific inhibitory MHC class I receptor activity

molecular adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Immunoglobulin

Functional Category

K: Transcription
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying 1 entry
InterPro
Immunoglobulin

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:12365	malaria	Alliance of Genome Resources
DOID:1883	hepatitis C	Alliance of Genome Resources
DOID:399	tuberculosis	Alliance of Genome Resources
DOID:526	human immunodeficiency virus infectious disease	Alliance of Genome Resources

Ortholog

Displaying **all 10** entries
Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	245615		MGI:3612791	MOUSE65566
Mus musculus	245616		MGI:2652397	MOUSE65572
Rattus norvegicus	353253		RGD:727836	RATNO20249
Pan troglodytes	456291	9598_0:004adb		PANTR19349
Pongo abelii	100437736	9601_0:004af2
Pan paniscus	100986982	9597_0:004f49
Pongo abelii	112131840	9601_0:0048fa
Gorilla gorilla gorilla	115930123	9595_0:004e29
Pongo pygmaeus	129020027	9600_0:004af1
Pongo pygmaeus	129020032	9600_0:004a9e

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements