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kallikrein B1

Summary

Gene Symbol

KLKB1

Organism

Homo sapiens (human)

External Links

NCBI Gene

3818

PubChem

3818

Alliance of Genome Resources

HGNC:6371

Annotation

Keyword

3D-structure
Blood coagulation
Direct protein sequencing
Disease variant
Disulfide bond
Fibrinolysis
Glycoprotein
Inflammatory response
Proteomics identification
Reference proteome
Repeat
Secreted
Serine protease
Signal
Zymogen

Proteins

Displaying **all 4** entries
UniProt	Protein Name
B4DMX2
P03952	Fletcher factor Kininogenin Plasma prekallikrein
E9PBC5
A8K9A9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

1

2

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GO Term	Evidence Code	PMID
proteolysis	TAS	1993180
plasminogen activation	IDA	89876
Factor XII activation	TAS	2510163
zymogen activation	TAS	2510163
positive regulation of fibrinolysis	IDA	89876

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

zymogen activation

plasminogen activation

protein maturation [inference]

protein processing [inference]

zymogen activation

plasminogen activation

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

zymogen activation

plasminogen activation

protein maturation [inference]

protein processing [inference]

zymogen activation

plasminogen activation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

zymogen activation

plasminogen activation

protein maturation [inference]

protein processing [inference]

zymogen activation

plasminogen activation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

zymogen activation

plasminogen activation

protein maturation [inference]

protein processing [inference]

zymogen activation

plasminogen activation

multicellular organismal process [inference]

coagulation [inference]

blood coagulation

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

Factor XII activation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

Factor XII activation

regulation of protein maturation [inference]

regulation of protein processing [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

Factor XII activation

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

Factor XII activation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

Factor XII activation

regulation of protein maturation [inference]

regulation of protein processing [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

Factor XII activation

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

Factor XII activation

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

Factor XII activation

regulation of protein processing [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

Factor XII activation

regulation of protein maturation [inference]

regulation of protein processing [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

Factor XII activation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

Factor XII activation

regulation of protein maturation [inference]

regulation of protein processing [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

Factor XII activation

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

Factor XII activation

regulation of protein processing [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

Factor XII activation

regulation of protein maturation [inference]

regulation of protein processing [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

Factor XII activation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

Factor XII activation

regulation of protein processing [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

Factor XII activation

regulation of protein maturation [inference]

regulation of protein processing [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of fibrinolysis

negative regulation of biological process [inference]

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation [inference]

negative regulation of blood coagulation [inference]

negative regulation of hemostasis [inference]

negative regulation of blood coagulation [inference]

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

regulation of fibrinolysis [inference]

positive regulation of fibrinolysis

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

regulation of inflammatory response [inference]

regulation of acute inflammatory response [inference]

Factor XII activation

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of inflammatory response [inference]

regulation of acute inflammatory response [inference]

Factor XII activation

regulation of response to wounding [inference]

regulation of wound healing [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

regulation of fibrinolysis [inference]

positive regulation of fibrinolysis

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

Factor XII activation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

Factor XII activation

regulation of protein maturation [inference]

regulation of protein processing [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

Factor XII activation

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of protein maturation [inference]

positive regulation of protein processing [inference]

Factor XII activation

regulation of multicellular organismal process [inference]

regulation of coagulation [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

regulation of fibrinolysis [inference]

positive regulation of fibrinolysis

negative regulation of coagulation [inference]

negative regulation of blood coagulation [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation [inference]

negative regulation of blood coagulation [inference]

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

regulation of fibrinolysis [inference]

positive regulation of fibrinolysis

negative regulation of hemostasis [inference]

negative regulation of blood coagulation [inference]

regulation of biological quality [inference]

regulation of body fluid levels [inference]

hemostasis [inference]

blood coagulation

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

regulation of fibrinolysis [inference]

positive regulation of fibrinolysis

negative regulation of hemostasis [inference]

negative regulation of blood coagulation [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
plasma membrane	TAS
extracellular region	NAS TAS	14718574
extracellular space	IDA	89876
extracellular exosome	HDA	23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	2844223 32814053
serine-type endopeptidase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

uncharacterized protein

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
proteolysis
serine-type endopeptidase activity

Displaying **all 5** entries
InterPro
Peptidase S1, PA clan, chymotrypsin-like fold
Peptidase S1, PA clan
Peptidase S1A, chymotrypsin family
Serine proteases, trypsin domain
Serine proteases, trypsin family, histidine active site

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:0050589	inflammatory bowel disease	Alliance of Genome Resources
DOID:0080162	lupus nephritis	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:2921	glomerulonephritis	Alliance of Genome Resources
DOID:5082	liver cirrhosis	Alliance of Genome Resources
DOID:9074	systemic lupus erythematosus	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 50 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	16621		MGI:102849	MOUSE57654
Rattus norvegicus	25048		RGD:67382	RATNO10641
Sus scrofa	397144			PIGXX09120
Xenopus laevis	446603		Xenbase:XB-GENE-985054
Pan troglodytes	471375	9598_0:001510		PANTR34935
Canis lupus familiaris	475624			CANLF04767
Bos taurus	533547			BOVIN21960
Macaca mulatta	696639			MACMU36672
Monodelphis domestica	100013981			MONDO26185
Ornithorhynchus anatinus	100086786			ORNAN04274

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements