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killer cell lectin like receptor D1

Summary

Gene Symbol

KLRD1

Organism

Homo sapiens (human)

External Links

NCBI Gene

3824

HGNC

6378

KEGG Gene ID

hsa:3824

PubChem

3824

Alliance of Genome Resources

HGNC:6378

Annotation

Keyword

3D-structure
Adaptive immunity
Alternative splicing
Cell membrane
Disulfide bond
Glycoprotein
Host-virus interaction
Innate immunity
Lectin
Receptor
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q13241	KP43 Killer cell lectin-like receptor subfamily D member 1 NK cell receptor
Q53ZY6	Killer cell lectin-like receptor subfamily D member 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

1

2

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GO Term	Evidence Code	PMID
adaptive immune response	IEA
natural killer cell mediated immunity	IDA	18448674
negative regulation of T cell mediated cytotoxicity	IDA	9485206
stimulatory C-type lectin receptor signaling pathway	IBA IDA	9655483
negative regulation of natural killer cell mediated cytotoxicity	IDA	9486650

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity [inference]

lymphocyte mediated immunity [inference]

natural killer cell mediated immunity

activation of immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

immune response [inference]

adaptive immune response

innate immune response [inference]

natural killer cell mediated immunity

cellular process [inference]

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

cell surface receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

natural killer cell mediated immunity

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response [inference]

natural killer cell mediated immunity

immune response [inference]

adaptive immune response

innate immune response [inference]

natural killer cell mediated immunity

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

natural killer cell mediated immunity

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

natural killer cell mediated immunity

response to lectin [inference]

cellular response to lectin [inference]

stimulatory C-type lectin receptor signaling pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of leukocyte mediated immunity [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated cytotoxicity

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated cytotoxicity

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

regulation of leukocyte activation [inference]

regulation of lymphocyte activation [inference]

regulation of natural killer cell activation

regulation of immune effector process [inference]

negative regulation of immune effector process [inference]

negative regulation of leukocyte mediated immunity [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated cytotoxicity

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

regulation of leukocyte mediated immunity [inference]

regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of natural killer cell mediated cytotoxicity

regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

negative regulation of leukocyte mediated immunity [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated cytotoxicity

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

positive regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

regulation of lymphocyte mediated immunity [inference]

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated cytotoxicity

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

regulation of T cell mediated immunity [inference]

regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated cytotoxicity

regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

regulation of adaptive immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated cytotoxicity

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of T cell mediated immunity [inference]

regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated cytotoxicity

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated cytotoxicity

regulation of innate immune response [inference]

regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated cytotoxicity

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of cellular process [inference]

positive regulation of cell killing [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of leukocyte mediated immunity [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of lymphocyte mediated immunity [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated cytotoxicity

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated cytotoxicity

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of cellular process [inference]

negative regulation of cell killing [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated cytotoxicity

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

regulation of innate immune response [inference]

regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

regulation of innate immune response [inference]

regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated cytotoxicity

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

regulation of adaptive immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated cytotoxicity

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of T cell mediated immunity [inference]

regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated cytotoxicity

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated cytotoxicity

regulation of innate immune response [inference]

regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

negative regulation of immune response [inference]

negative regulation of adaptive immune response [inference]

negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

negative regulation of T cell mediated immunity [inference]

negative regulation of T cell mediated cytotoxicity

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

regulation of innate immune response [inference]

regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

positive regulation of natural killer cell mediated immunity [inference]

positive regulation of natural killer cell mediated cytotoxicity

negative regulation of innate immune response [inference]

negative regulation of natural killer cell mediated immunity [inference]

negative regulation of natural killer cell mediated cytotoxicity

regulation of cellular process [inference]

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

innate immune response-activating signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

cell surface receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

innate immune response activating cell surface receptor signaling pathway [inference]

stimulatory C-type lectin receptor signaling pathway

regulation of cell killing [inference]

regulation of leukocyte mediated cytotoxicity [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of natural killer cell mediated cytotoxicity

regulation of T cell mediated cytotoxicity [inference]

negative regulation of T cell mediated cytotoxicity

regulation of natural killer cell mediated cytotoxicity [inference]

negative regulation of cell killing [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of cell killing [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of cellular process [inference]

positive regulation of cell killing [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of natural killer cell mediated cytotoxicity

negative regulation of cellular process [inference]

negative regulation of cell killing [inference]

negative regulation of leukocyte mediated cytotoxicity [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

regulation of lymphocyte activation [inference]

regulation of natural killer cell activation

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

regulation of lymphocyte activation [inference]

regulation of natural killer cell activation

Displaying **all 3** entries
GO Term	Evidence Code	PMID
receptor complex	IDA IPI ISS	18448674
external side of plasma membrane	IBA
plasma membrane	IDA ISO TAS	18448674 9485206 9486650 9655483

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

side of membrane [inference]

external side of plasma membrane

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GO Term	Evidence Code	PMID
HLA-E specific inhibitory MHC class Ib receptor activity	IDA	9486650
transmembrane signaling receptor activity	IBA
MHC class Ib protein binding, via antigen binding groove	IPI	25631937
protein antigen binding	IDA	18448674
carbohydrate binding	IEA

GO Hierarchy

molecular function

binding [inference]

antigen binding [inference]

protein antigen binding

protein binding

signaling receptor binding [inference]

MHC protein binding [inference]

MHC class Ib protein binding [inference]

MHC class Ib protein binding, via antigen binding groove

protein antigen binding

carbohydrate binding

protein-containing complex binding [inference]

MHC protein complex binding [inference]

MHC class I protein complex binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity

MHC class Ib receptor activity [inference]

inhibitory MHC class Ib receptor activity [inference]

HLA-E specific inhibitory MHC class Ib receptor activity

immune receptor activity [inference]

MHC class Ib receptor activity [inference]

inhibitory MHC class Ib receptor activity [inference]

HLA-E specific inhibitory MHC class Ib receptor activity

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K06516

Name

killer cell lectin-like receptor subfamily D member 1

References

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0110741	type 1 diabetes mellitus 2	DisGeNET
DOID:0110742	type 1 diabetes mellitus 3	DisGeNET
DOID:0110743	type 1 diabetes mellitus 4	DisGeNET
DOID:0110744	type 1 diabetes mellitus 5	DisGeNET
DOID:0110745	type 1 diabetes mellitus 6	DisGeNET
DOID:0110746	type 1 diabetes mellitus 7	DisGeNET
DOID:0110747	type 1 diabetes mellitus 8	DisGeNET
DOID:0110748	obsolete type 1 diabetes mellitus 9	DisGeNET
DOID:0110749	type 1 diabetes mellitus 10	DisGeNET
DOID:0110750	type 1 diabetes mellitus 11	DisGeNET

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	14462692	FB:FBgn0264341
Ornithorhynchus anatinus	114817875		ORNAN08811
Callithrix jacchus	100399584		CALJA44334
Cercocebus atys	105588000		CERAT39983
Macaca fascicularis	102119829		MACFA02528
Macaca mulatta	574145		MACMU03559
Macaca nemestrina	105499930		MACNE16815
Papio anubis	101012399		PAPAN42009
Mandrillus leucophaeus	105542007		MANLE19799
Gorilla gorilla gorilla	101124666		GORGO05023

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

International Collaboration

Acknowledgements