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kinesin family member 22

Summary

Gene Symbol

KIF22

Organism

Homo sapiens (human)

External Links

NCBI Gene

3835

PubChem

3835

Alliance of Genome Resources

HGNC:6391

JoGo

KIF22

TogoVar

KIF22

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Coiled coil
Cytoskeleton
DNA-binding
Disease variant
Dwarfism
Isopeptide bond
Microtubule
Motor protein
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Ubl conjugation

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q14807	Kinesin-like DNA-binding protein Kinesin-like protein 4
B7Z9T5
A0A8I5QL17

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
mitotic cell cycle	TAS	8599929
DNA repair	IEA
microtubule-based movement	IBA
sister chromatid cohesion	IMP	15843429
mitotic metaphase chromosome alignment	IMP	15843429

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement

cell cycle [inference]

mitotic cell cycle

cell cycle process [inference]

sister chromatid cohesion

mitotic cell cycle process [inference]

mitotic metaphase chromosome alignment

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

sister chromatid cohesion

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

localization [inference]

establishment of localization [inference]

establishment of localization in cell [inference]

establishment of chromosome localization [inference]

metaphase chromosome alignment

mitotic metaphase chromosome alignment

establishment of organelle localization [inference]

establishment of chromosome localization [inference]

metaphase chromosome alignment

mitotic metaphase chromosome alignment

organelle localization [inference]

chromosome localization [inference]

establishment of chromosome localization [inference]

metaphase chromosome alignment

mitotic metaphase chromosome alignment

establishment of organelle localization [inference]

establishment of chromosome localization [inference]

metaphase chromosome alignment

mitotic metaphase chromosome alignment

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
kinetochore	TAS	8599929
chromatin	IEA
nucleus	TAS	8599929
cytoplasm	IBA
cytosol	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

microtubule associated complex [inference]

kinesin complex

protein-DNA complex [inference]

chromatin

cellular anatomical entity [inference]

nuclear body [inference]

nuclear speck

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

kinetochore

spindle [inference]

mitotic spindle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

kinetochore

spindle [inference]

mitotic spindle

supramolecular complex [inference]

kinetochore

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
DNA binding	IEA
microtubule motor activity	IBA
protein binding	IPI	18485706
ATP binding	IEA
microtubule binding	IBA

GO Hierarchy

molecular function

cytoskeletal motor activity [inference]

microtubule motor activity

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

protein binding

cytoskeletal protein binding [inference]

tubulin binding [inference]

microtubule binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

microtubule motor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Kinesin

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
ATP binding
cytoskeletal motor activity
microtubule binding
microtubule-based movement
nucleotide binding
plus-end-directed microtubule motor activity

Displaying **all 5** entries
InterPro
Kinesin motor domain superfamily
Kinesin motor domain
Kinesin-like protein
P-loop containing nucleoside triphosphate hydrolase
RuvA domain 2-like

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0112199	spondyloepimetaphyseal dysplasia with joint laxity type 2	Alliance of Genome Resources

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements