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spatzle 5

Summary

Gene Symbol

spz5

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

38350

PubChem

38350

Alliance of Genome Resources

FB:FBgn0035379

Annotation

Keyword

Disulfide bond
Glycoprotein
Reference proteome
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9VZX1	Neurotrophic factor 2 Protein spatzle 5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

1

2

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GO Term	Evidence Code	PMID
positive regulation of antimicrobial peptide production	IMP	30361090
motor neuron axon guidance	IMP	19018662
Toll signaling pathway	IDA	30361090 31088910
Toll signaling pathway	IGI	30361090
central nervous system formation	IMP	19018662

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

innate immune response

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Toll signaling pathway

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance [inference]

motor neuron axon guidance

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

central nervous system formation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

regulation of immune effector process [inference]

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production

regulation of immune response [inference]

regulation of humoral immune response [inference]

regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

regulation of neuronal synaptic plasticity [inference]

regulation of neuronal synaptic plasticity in response to neurotrophin

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of defense response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of response to external stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production

positive regulation of response to biotic stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

regulation of response to external stimulus [inference]

regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production

positive regulation of response to external stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of defense response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of response to external stimulus [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

regulation of immune response [inference]

regulation of humoral immune response [inference]

regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

positive regulation of immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production

positive regulation of defense response [inference]

positive regulation of antimicrobial humoral response [inference]

positive regulation of antimicrobial peptide production

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Toll signaling pathway

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

regulation of neuronal synaptic plasticity [inference]

regulation of neuronal synaptic plasticity in response to neurotrophin

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

regulation of antimicrobial peptide production [inference]

positive regulation of antimicrobial peptide production

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of neuron apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of antimicrobial peptide production

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of biological quality [inference]

regulation of synaptic plasticity

regulation of neuronal synaptic plasticity [inference]

regulation of neuronal synaptic plasticity in response to neurotrophin

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular region	IBA
extracellular space	IDA	31088910

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying entries **1 - 5** of 6 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
Toll binding	IDA	31088910
Toll binding	IBA
growth factor activity	IMP	19018662
growth factor activity	IBA
receptor ligand activity	IDA	30361090 31088910

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

Toll binding

receptor ligand activity

growth factor activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

growth factor activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

growth factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Protein spaetzle 5

Functional Category

I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
Toll binding
central nervous system formation
growth factor activity

Displaying **all 2** entries
InterPro
Cystine-knot cytokine
Spaetzle

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
extracellular space	PMID:31088910

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements