GlyCosmos Portal

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GO Term	Evidence Code	PMID
GTPase activity	TAS
GTPase activity	IMP	26037647
GTPase activity	IBA
G protein activity	IEA
protein binding	IPI	10673434 12732644 15451670 20080631 20802526 24415755 25416956 25852190 28619714 30194290 31980649 32814053

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

GTPase activity

G protein activity

binding [inference]

protein binding

identical protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

ion binding [inference]

anion binding [inference]

GDP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

protein-containing complex binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

protein-membrane adaptor activity

molecular function regulator activity [inference]

G protein activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Ras

Functional Category

J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
GDP binding
GTP binding

Displaying **all 4** entries
InterPro
P-loop containing nucleoside triphosphate hydrolase
Small GTP-binding protein domain
Small GTPase, Ras-type
Small GTPase

Human Protein Atlas

ENSG00000133703

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Rhea

RHEA:19669

H₂O + GTP

H⁺ + phosphate + GDP

Enzyme

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 28 in total

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DO ID	Disease Name	Source
DOID:0060233	cardiofaciocutaneous syndrome	Alliance of Genome Resources
DOID:0060581	Noonan syndrome 3	Alliance of Genome Resources
DOID:0060688	arteriovenous malformations of the brain	Alliance of Genome Resources
DOID:0080365	endometrial hyperplasia	Alliance of Genome Resources
DOID:0110117	autoimmune lymphoproliferative syndrome type 4	Alliance of Genome Resources
DOID:0111461	cardiofaciocutaneous syndrome 2	Alliance of Genome Resources
DOID:0111530	linear nevus sebaceous syndrome	Alliance of Genome Resources
DOID:0111705	oculoectodermal syndrome	Alliance of Genome Resources
DOID:10534	stomach cancer	Alliance of Genome Resources
DOID:1059	intellectual disability	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of **363** in total

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HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000014	Abnormality of the bladder
HP:0000028	Cryptorchidism
HP:0000036	Abnormal penis morphology
HP:0000039	Epispadias
HP:0000044	Hypogonadotropic hypogonadism
HP:0000047	Hypospadias
HP:0000069	Abnormality of the ureter
HP:0000078	Abnormality of the genital system
HP:0000085	Horseshoe kidney

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Disease ID	Disease Name
ORPHA:1340	cardiofaciocutaneous syndrome
OMIM:163200	linear nevus sebaceous syndrome
OMIM:615278	cardiofaciocutaneous syndrome 2
OMIM:108010	arteriovenous malformations of the brain
OMIM:609942	Noonan syndrome 3
OMIM:601626	acute myeloid leukemia
ORPHA:1333	familial pancreatic carcinoma
OMIM:614470	autoimmune lymphoproliferative syndrome type 4
OMIM:114480	hereditary breast carcinoma
OMIM:109800	urinary bladder cancer

PubChem Disease

GHR Health Conditions

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	3265	FB:FBgn0003205
Xenopus tropicalis	3845	Xenbase:XB-GENE-22063560
Drosophila melanogaster	4893	FB:FBgn0003205
Mus musculus	16653	Xenbase:XB-GENE-22063560	MOUSE48355
Canis lupus familiaris	403871		CANLF10970
Pan troglodytes	473387		PANTR06268
Bos taurus	541140		BOVIN30074
Monodelphis domestica	554186		MONDO34878
Macaca mulatta	707977		MACMU03745
Felis catus	751104		FELCA15885

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

PubChem Disease

International Collaboration

Acknowledgements