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keratin 8

Summary

Gene Symbol

KRT8

Organism

Homo sapiens (human)

External Links

NCBI Gene

3856

PubChem

3856

Alliance of Genome Resources

HGNC:6446

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Coiled coil
Cytoplasm
Direct protein sequencing
Disease variant
Glycoprotein
Host-virus interaction
Intermediate filament
Isopeptide bond
Keratin
Methylation
Nucleus
Phosphoprotein
Reference proteome
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q7L4M3	Cytokeratin-8 Keratin-8
P05787	Cytokeratin-8 Keratin-8 Type-II keratin Kb8

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
cell differentiation involved in embryonic placenta development	IEA
response to other organism	IEA
sarcomere organization	IEA
response to hydrostatic pressure	IEA
tumor necrosis factor-mediated signaling pathway	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

tumor necrosis factor-mediated signaling pathway

extrinsic apoptotic signaling pathway

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

epithelial cell apoptotic process [inference]

hepatocyte apoptotic process

actin filament-based process [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

sarcomere organization

cellular developmental process [inference]

cell differentiation [inference]

cell differentiation involved in embryonic placenta development

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

sarcomere organization

reproductive process [inference]

developmental process involved in reproduction [inference]

cell differentiation involved in embryonic placenta development

developmental process [inference]

developmental process involved in reproduction [inference]

cell differentiation involved in embryonic placenta development

cellular developmental process [inference]

cell differentiation [inference]

cell differentiation involved in embryonic placenta development

biological process involved in interspecies interaction between organisms [inference]

response to other organism

response to stimulus [inference]

response to stress [inference]

response to hydrostatic pressure

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism

response to abiotic stimulus [inference]

response to water [inference]

response to hydrostatic pressure

response to chemical [inference]

response to acid chemical [inference]

response to water [inference]

response to hydrostatic pressure

response to organic substance [inference]

response to water [inference]

response to hydrostatic pressure

response to inorganic substance [inference]

response to water [inference]

response to hydrostatic pressure

response to oxygen-containing compound [inference]

response to water [inference]

response to hydrostatic pressure

response to salt [inference]

response to water [inference]

response to hydrostatic pressure

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

tumor necrosis factor-mediated signaling pathway

extrinsic apoptotic signaling pathway

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
intermediate filament cytoskeleton	IDA
apicolateral plasma membrane	IEA
sarcolemma	IEA
keratin filament	IPI	10852826
nuclear matrix	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

glycoprotein complex [inference]

dystrophin-associated glycoprotein complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

dystrophin-associated glycoprotein complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane [inference]

sarcolemma

plasma membrane region [inference]

apicolateral plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction

costamere

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

intermediate filament cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

intermediate filament cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

intermediate filament

keratin filament

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	10852826 10954706 11684708 12577067 14756564 15671067 15731013 15846844 16608857 19188445 20936779 21149639 21988832 22038833 22458338 24940650 25416956 26769854 30021884 31515488 32296183 32814053 36012204
protein-containing complex binding	IEA
scaffold protein binding	IPI	10852826

GO Hierarchy

molecular function

binding [inference]

protein binding

scaffold protein binding

protein-containing complex binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

keratin, type II cytoskeletal 8

Functional Category

M: Cell wall/membrane/envelope biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
intermediate filament organization
keratinization
structural constituent of skin epidermis

Displaying 1 entry
InterPro
Intermediate filament, rod domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:5082	liver cirrhosis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 69 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	16691		MGI:96705	MOUSE16760
Rattus norvegicus	25626		RGD:2984	RATNO38505
Caenorhabditis elegans	180430		WB:WBGene00002058
Bos taurus	281269			BOVIN29100
Xenopus laevis	380217		Xenbase:XB-GENE-876943
Canis lupus familiaris	485387			CANLF10752
Canis lupus familiaris	486513			CANLF10752
Pan troglodytes	737628	9598_0:003648		PANTR05783
Danio rerio	794486		ZFIN:ZDB-GENE-000607-83
Danio rerio	797351		ZFIN:ZDB-GENE-991110-23

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements