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Guidelines

MIRAGE

shisa family member 6

Summary

Gene Symbol

SHISA6

Organism

Homo sapiens (human)

External Links

NCBI Gene

388336

PubChem

388336

Alliance of Genome Resources

HGNC:34491

Annotation

Keyword

Alternative splicing
Glycoprotein
Phosphoprotein
Reference proteome
Signal
Synapse
Transmembrane helix
Wnt signaling pathway

Proteins

Displaying 1 entry
UniProt	Protein Name
Q6ZSJ9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
excitatory chemical synaptic transmission	ISS
regulation of AMPA glutamate receptor clustering	ISS

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

excitatory chemical synaptic transmission

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

cellular localization [inference]

localization within membrane [inference]

receptor diffusion trapping [inference]

neurotransmitter receptor diffusion trapping [inference]

postsynaptic neurotransmitter receptor diffusion trapping

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

localization [inference]

protein-containing complex localization [inference]

receptor localization to synapse [inference]

postsynaptic neurotransmitter receptor diffusion trapping

receptor diffusion trapping [inference]

neurotransmitter receptor diffusion trapping [inference]

postsynaptic neurotransmitter receptor diffusion trapping

cellular localization [inference]

localization within membrane [inference]

receptor diffusion trapping [inference]

neurotransmitter receptor diffusion trapping [inference]

postsynaptic neurotransmitter receptor diffusion trapping

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity [inference]

regulation of short-term neuronal synaptic plasticity

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

excitatory chemical synaptic transmission

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to membrane [inference]

regulation of receptor clustering [inference]

regulation of glutamate receptor clustering [inference]

regulation of AMPA glutamate receptor clustering

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity [inference]

regulation of short-term neuronal synaptic plasticity

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to membrane [inference]

regulation of receptor clustering [inference]

regulation of glutamate receptor clustering [inference]

regulation of AMPA glutamate receptor clustering

regulation of biological quality [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity [inference]

regulation of short-term neuronal synaptic plasticity

regulation of postsynaptic membrane neurotransmitter receptor levels [inference]

postsynaptic neurotransmitter receptor diffusion trapping

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
postsynaptic density	ISS
postsynaptic density	IBA
AMPA glutamate receptor complex	IBA
dendritic spine membrane	IBA
postsynaptic membrane	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

ionotropic glutamate receptor complex [inference]

AMPA glutamate receptor complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

ionotropic glutamate receptor complex [inference]

AMPA glutamate receptor complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

ionotropic glutamate receptor complex [inference]

AMPA glutamate receptor complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

ionotropic glutamate receptor complex [inference]

AMPA glutamate receptor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane region [inference]

cell projection membrane [inference]

neuron projection membrane [inference]

dendritic spine membrane

synaptic membrane [inference]

postsynaptic specialization membrane [inference]

postsynaptic density membrane

cell junction [inference]

synapse [inference]

excitatory synapse [inference]

asymmetric, glutamatergic, excitatory synapse

glutamatergic synapse [inference]

asymmetric, glutamatergic, excitatory synapse

neuron to neuron synapse [inference]

asymmetric synapse [inference]

asymmetric, glutamatergic, excitatory synapse

leading edge membrane [inference]

neuron projection membrane [inference]

dendritic spine membrane

organelle [inference]

postsynaptic specialization [inference]

postsynaptic density

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	32296183
PDZ domain binding	IEA
ionotropic glutamate receptor binding	ISS
ionotropic glutamate receptor binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

glutamate receptor binding [inference]

ionotropic glutamate receptor binding

protein domain specific binding [inference]

PDZ domain binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

protein shisa-6

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
regulation of short-term neuronal synaptic plasticity

Displaying 1 entry
InterPro
Shisa family

Ortholog

Displaying entries **1 - 10** of 32 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	380702	RGD:1564618	MOUSE04950
Xenopus laevis	388336	Xenbase:XB-GENE-17334321
Rattus norvegicus	497926		RATNO01164
Macaca mulatta	722098		MACMU16259
Pan troglodytes	746253		PANTR14761
Taeniopygia guttata	100228439		TAEGU07077
Oryctolagus cuniculus	100347431		RABIT07138
Callithrix jacchus	100386882		CALJA33430
Pongo abelii	100437236		PONAB12897
Nomascus leucogenys	100603703		NOMLE15855

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Last updated: December 8, 2025