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ALK and LTK ligand 1

Summary

Gene Symbol

ALKAL1

Organism

Homo sapiens (human)

External Links

NCBI Gene

389658

PubChem

389658

Alliance of Genome Resources

HGNC:33775

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Cytokine
Disulfide bond
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q6UXT8	Augmentor beta

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
positive regulation of neuron projection development	IDA	26418745
transmembrane receptor protein tyrosine kinase signaling pathway	IDA	34646012 34819673
positive regulation of ERK1 and ERK2 cascade	IBA IDA	26418745
positive regulation of ERK5 cascade	IBA IDA	26418745

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK5 cascade [inference]

positive regulation of ERK5 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK5 cascade [inference]

positive regulation of ERK5 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK5 cascade [inference]

positive regulation of ERK5 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

positive regulation of neuron projection development

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

Displaying **all 3** entries
GO Term	Evidence Code	PMID
plasma membrane	IEA
extracellular region	TAS
extracellular space	IDA	34646012

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	26418745
receptor signaling protein tyrosine kinase activator activity	IBA IDA	26418745 34646012 34819673
cytokine activity	IDA	34646012 34819673
transmembrane receptor protein tyrosine kinase activator activity	IDA	34646012 34819673
receptor tyrosine kinase binding	IBA IDA	26418745

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

receptor tyrosine kinase binding

receptor ligand activity [inference]

cytokine activity

enzyme binding [inference]

kinase binding [inference]

protein kinase binding [inference]

protein tyrosine kinase binding [inference]

receptor tyrosine kinase binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

kinase activator activity [inference]

protein kinase activator activity [inference]

protein tyrosine kinase activator activity [inference]

kinase regulator activity [inference]

kinase activator activity [inference]

protein kinase activator activity [inference]

protein tyrosine kinase activator activity [inference]

protein kinase regulator activity [inference]

protein kinase activator activity [inference]

protein tyrosine kinase activator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

transmembrane receptor protein tyrosine kinase activator activity

receptor ligand activity [inference]

cytokine activity

molecular function activator activity [inference]

enzyme activator activity [inference]

kinase activator activity [inference]

protein kinase activator activity [inference]

protein tyrosine kinase activator activity [inference]

signaling receptor activator activity [inference]

transmembrane receptor protein tyrosine kinase activator activity

receptor ligand activity [inference]

cytokine activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ALK and LTK ligand 2

Functional Category

G: Carbohydrate transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
cytokine activity
positive regulation of ERK1 and ERK2 cascade
positive regulation of ERK5 cascade
receptor signaling protein tyrosine kinase activator activity
receptor tyrosine kinase binding

Displaying 1 entry
InterPro
ALK and LTK ligand 1/2

Ortholog

Displaying entries **1 - 10** of 39 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	620393		MGI:3645495	MOUSE30431
Rattus norvegicus	681161		RGD:1583530
Macaca mulatta	717570			MACMU43854
Pan troglodytes	739899	9598_0:0026f3		PANTR42541
Equus caballus	100050264			HORSE43240
Oryctolagus cuniculus	100352145			RABIT09668
Callithrix jacchus	100407625			CALJA14372
Pongo abelii	100436653	9601_0:00250d		PONAB35290
Xenopus tropicalis	100487397		Xenbase:XB-GENE-6043666
Danio rerio	100535009		ZFIN:ZDB-GENE-110411-243