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low density lipoprotein receptor

Summary

Gene Symbol

LDLR

Organism

Homo sapiens (human)

External Links

NCBI Gene

3949

PubChem

3949

Alliance of Genome Resources

HGNC:6547

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Cholesterol metabolism
Coated pit
Direct protein sequencing
Disease variant
Disulfide bond
EGF-like domain
Endocytosis
Endosome
Glycoprotein
Golgi apparatus
Host cell receptor for virus entry
Host-virus interaction
LDL
Lipid transport
Lysosome
Phosphoprotein
Reference proteome
Repeat
Signal
Transmembrane helix
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P01130

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 37 in total

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GO Term	Evidence Code	PMID
receptor-mediated endocytosis involved in cholesterol transport	IBA IMP	6299582
amyloid-beta clearance	ISS
phospholipid transport	ISS
cholesterol metabolic process	IEA
regulation of protein metabolic process	IGI	24412220

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

lipoprotein metabolic process [inference]

lipoprotein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

catabolic process [inference]

cellular catabolic process [inference]

amyloid-beta clearance by cellular catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

amyloid-beta clearance by cellular catabolic process

primary metabolic process [inference]

lipid metabolic process

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

protein metabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

lipoprotein metabolic process [inference]

lipoprotein catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

organic substance metabolic process [inference]

lipid metabolic process

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

protein metabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

lipoprotein metabolic process [inference]

lipoprotein catabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

lipoprotein metabolic process [inference]

lipoprotein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis

receptor-mediated endocytosis

receptor-mediated endocytosis involved in cholesterol transport

phagocytosis

cellular metabolic process [inference]

cellular catabolic process [inference]

amyloid-beta clearance by cellular catabolic process

cellular localization [inference]

intracellular transport [inference]

receptor-mediated endocytosis involved in cholesterol transport

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to fatty acid

cellular response to oxygen-containing compound [inference]

cellular response to fatty acid

cellular response to lipoprotein particle stimulus [inference]

cellular response to low-density lipoprotein particle stimulus

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

intestinal absorption [inference]

intestinal lipid absorption [inference]

intestinal cholesterol absorption

nervous system process [inference]

cognition [inference]

learning or memory [inference]

memory [inference]

long-term memory

behavior [inference]

learning or memory [inference]

memory [inference]

long-term memory

plasma lipoprotein particle clearance

amyloid-beta clearance

amyloid-beta clearance by cellular catabolic process

developmental process [inference]

anatomical structure morphogenesis [inference]

tube morphogenesis [inference]

blood vessel morphogenesis [inference]

artery morphogenesis

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

sterol homeostasis [inference]

cholesterol homeostasis

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

movement in host [inference]

entry into host [inference]

viral entry into host cell

response to stimulus [inference]

response to stress [inference]

response to caloric restriction

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to caloric restriction

response to endogenous stimulus [inference]

response to lipoprotein particle [inference]

cellular response to low-density lipoprotein particle stimulus

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to lipoprotein particle [inference]

cellular response to low-density lipoprotein particle stimulus

response to lipid [inference]

response to fatty acid [inference]

cellular response to fatty acid

cellular response to lipid [inference]

cellular response to fatty acid

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to fatty acid

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to fatty acid

cellular response to oxygen-containing compound [inference]

cellular response to fatty acid

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to lipoprotein particle [inference]

cellular response to low-density lipoprotein particle stimulus

response to oxygen-containing compound [inference]

response to fatty acid [inference]

cellular response to fatty acid

cellular response to oxygen-containing compound [inference]

cellular response to fatty acid

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to fatty acid

cellular response to oxygen-containing compound [inference]

cellular response to fatty acid

cellular response to lipoprotein particle stimulus [inference]

cellular response to low-density lipoprotein particle stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis

receptor-mediated endocytosis

receptor-mediated endocytosis involved in cholesterol transport

phagocytosis

intracellular transport [inference]

receptor-mediated endocytosis involved in cholesterol transport

intestinal absorption [inference]

intestinal lipid absorption [inference]

intestinal cholesterol absorption

organic substance transport [inference]

lipid transport [inference]

phospholipid transport

sterol transport [inference]

cholesterol transport

intestinal lipid absorption [inference]

intestinal cholesterol absorption

organophosphate ester transport [inference]

phospholipid transport

organic hydroxy compound transport [inference]

sterol transport [inference]

cholesterol transport

import into cell [inference]

endocytosis

receptor-mediated endocytosis

receptor-mediated endocytosis involved in cholesterol transport

phagocytosis

establishment of localization in cell [inference]

intracellular transport [inference]

receptor-mediated endocytosis involved in cholesterol transport

cellular localization [inference]

intracellular transport [inference]

receptor-mediated endocytosis involved in cholesterol transport

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

regulation of macrophage activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

regulation of microglial cell activation [inference]

negative regulation of microglial cell activation

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of triglyceride biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of triglyceride biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of triglyceride biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of triglyceride biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of receptor recycling

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of protein metabolic process

negative regulation of amyloid fibril formation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process

negative regulation of amyloid fibril formation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of triglyceride biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of cellular catabolic process [inference]

regulation of phospholipid catabolic process [inference]

regulation of phosphatidylcholine catabolic process

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of protein catabolic process in the vacuole [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of lysosomal protein catabolic process [inference]

positive regulation of lysosomal protein catabolic process

regulation of lipid catabolic process [inference]

regulation of phospholipid catabolic process [inference]

regulation of phosphatidylcholine catabolic process

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of triglyceride biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of triglyceride biosynthetic process

regulation of cellular catabolic process [inference]

regulation of phospholipid catabolic process [inference]

regulation of phosphatidylcholine catabolic process

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phospholipid metabolic process [inference]

regulation of phospholipid catabolic process [inference]

regulation of phosphatidylcholine catabolic process

regulation of phosphatidylcholine metabolic process [inference]

regulation of phosphatidylcholine catabolic process

regulation of triglyceride metabolic process [inference]

regulation of triglyceride biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process

negative regulation of amyloid fibril formation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of protein metabolic process

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of protein catabolic process in the vacuole [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of lysosomal protein catabolic process [inference]

positive regulation of lysosomal protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

negative regulation of protein metabolic process

negative regulation of amyloid fibril formation

regulation of amyloid fibril formation [inference]

negative regulation of amyloid fibril formation

regulation of phosphatidylcholine metabolic process [inference]

regulation of phosphatidylcholine catabolic process

regulation of macromolecule metabolic process [inference]

regulation of receptor recycling [inference]

negative regulation of receptor recycling

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of receptor recycling

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of protein metabolic process

negative regulation of amyloid fibril formation

regulation of protein metabolic process

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of protein catabolic process in the vacuole [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of lysosomal protein catabolic process [inference]

positive regulation of lysosomal protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

negative regulation of protein metabolic process

negative regulation of amyloid fibril formation

regulation of amyloid fibril formation [inference]

negative regulation of amyloid fibril formation

regulation of small molecule metabolic process [inference]

regulation of cholesterol metabolic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of steroid metabolic process [inference]

regulation of cholesterol metabolic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of triglyceride biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

regulation of lipid catabolic process [inference]

regulation of phospholipid catabolic process [inference]

regulation of phosphatidylcholine catabolic process

regulation of triglyceride metabolic process [inference]

regulation of triglyceride biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

regulation of phospholipid metabolic process [inference]

regulation of phospholipid catabolic process [inference]

regulation of phosphatidylcholine catabolic process

regulation of phosphatidylcholine metabolic process [inference]

regulation of phosphatidylcholine catabolic process

regulation of protein metabolic process

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of protein catabolic process in the vacuole [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of lysosomal protein catabolic process [inference]

positive regulation of lysosomal protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

negative regulation of protein metabolic process

negative regulation of amyloid fibril formation

regulation of amyloid fibril formation [inference]

negative regulation of amyloid fibril formation

regulation of signaling [inference]

regulation of receptor recycling [inference]

negative regulation of receptor recycling

negative regulation of signaling [inference]

negative regulation of receptor recycling

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of triglyceride biosynthetic process

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of receptor recycling

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of protein metabolic process

negative regulation of amyloid fibril formation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process

negative regulation of amyloid fibril formation

negative regulation of signaling [inference]

negative regulation of receptor recycling

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of astrocyte activation

negative regulation of cellular component organization [inference]

negative regulation of supramolecular fiber organization [inference]

negative regulation of amyloid fibril formation

negative regulation of response to stimulus [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response [inference]

negative regulation of neuroinflammatory response [inference]

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response [inference]

negative regulation of neuroinflammatory response [inference]

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

negative regulation of multicellular organismal process [inference]

negative regulation of lipoprotein particle clearance [inference]

negative regulation of low-density lipoprotein particle clearance

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of astrocyte activation

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response [inference]

negative regulation of neuroinflammatory response [inference]

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

regulation of inflammatory response [inference]

negative regulation of inflammatory response [inference]

negative regulation of neuroinflammatory response [inference]

positive regulation of inflammatory response

regulation of neuroinflammatory response [inference]

negative regulation of neuroinflammatory response [inference]

regulation of microglial cell activation [inference]

negative regulation of microglial cell activation

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

negative regulation of response to stimulus [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response [inference]

negative regulation of neuroinflammatory response [inference]

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response [inference]

negative regulation of neuroinflammatory response [inference]

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response [inference]

negative regulation of neuroinflammatory response [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

regulation of inflammatory response [inference]

negative regulation of inflammatory response [inference]

negative regulation of neuroinflammatory response [inference]

positive regulation of inflammatory response

regulation of neuroinflammatory response [inference]

negative regulation of neuroinflammatory response [inference]

regulation of microglial cell activation [inference]

negative regulation of microglial cell activation

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

regulation of glial cell differentiation [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

regulation of astrocyte differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

regulation of astrocyte activation [inference]

negative regulation of astrocyte activation

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of triglyceride biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of triglyceride biosynthetic process

regulation of cellular catabolic process [inference]

regulation of phospholipid catabolic process [inference]

regulation of phosphatidylcholine catabolic process

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phospholipid metabolic process [inference]

regulation of phospholipid catabolic process [inference]

regulation of phosphatidylcholine catabolic process

regulation of phosphatidylcholine metabolic process [inference]

regulation of phosphatidylcholine catabolic process

regulation of triglyceride metabolic process [inference]

regulation of triglyceride biosynthetic process [inference]

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

regulation of glial cell differentiation [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

regulation of astrocyte differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

regulation of astrocyte activation [inference]

negative regulation of astrocyte activation

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of triglyceride biosynthetic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride biosynthetic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of astrocyte activation

negative regulation of cellular component organization [inference]

negative regulation of supramolecular fiber organization [inference]

negative regulation of amyloid fibril formation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

regulation of macrophage activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

regulation of microglial cell activation [inference]

negative regulation of microglial cell activation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of astrocyte activation

regulation of astrocyte activation [inference]

negative regulation of astrocyte activation

regulation of cellular component organization [inference]

negative regulation of cellular component organization [inference]

negative regulation of supramolecular fiber organization [inference]

negative regulation of amyloid fibril formation

regulation of supramolecular fiber organization [inference]

negative regulation of supramolecular fiber organization [inference]

negative regulation of amyloid fibril formation

regulation of amyloid fibril formation [inference]

negative regulation of amyloid fibril formation

regulation of multicellular organismal process [inference]

regulation of lipoprotein particle clearance [inference]

negative regulation of lipoprotein particle clearance [inference]

negative regulation of low-density lipoprotein particle clearance

regulation of low-density lipoprotein particle clearance [inference]

negative regulation of low-density lipoprotein particle clearance

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

regulation of macrophage activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

regulation of microglial cell activation [inference]

negative regulation of microglial cell activation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of astrocyte activation

regulation of astrocyte activation [inference]

negative regulation of astrocyte activation

negative regulation of multicellular organismal process [inference]

negative regulation of lipoprotein particle clearance [inference]

negative regulation of low-density lipoprotein particle clearance

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of astrocyte activation

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of gliogenesis [inference]

negative regulation of glial cell differentiation [inference]

negative regulation of astrocyte differentiation [inference]

negative regulation of astrocyte activation

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
external side of plasma membrane	IDA	15166224
membrane	HDA	19946888
early endosome	IBA IDA	15166224 17461796
Golgi apparatus	IDA	17461796
late endosome	IDA	17461796

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-lipid complex [inference]

lipoprotein particle [inference]

plasma lipoprotein particle [inference]

low-density lipoprotein particle

cellular anatomical entity [inference]

cell surface

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

endolysosome membrane

coated vesicle membrane [inference]

clathrin-coated vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

endocytic vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane [inference]

endolysosome membrane

endosome membrane

endolysosome membrane

coated vesicle membrane [inference]

clathrin-coated vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

endocytic vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

plasma membrane region [inference]

somatodendritic compartment

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

apical part of cell

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	10571240 12221107 17452316 17461796 18250299 18753623 20030366 20223219 22081141 22509010 23589850 24447298 25613181 28514442 30443021 32296183 33420426 33961781
low-density lipoprotein particle receptor activity	IBA IC IDA IMP TAS	20005821 22848640 6091915 6299582 8626535
low-density lipoprotein particle binding	IMP	6299582
protease binding	IPI	22081141 22848640
lipoprotein particle binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

protease binding

clathrin binding [inference]

clathrin heavy chain binding

identical protein binding

exogenous protein binding [inference]

virus receptor activity

amide binding [inference]

peptide binding [inference]

amyloid-beta binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding [inference]

protein-lipid complex binding [inference]

lipoprotein particle binding

low-density lipoprotein particle binding

cargo receptor activity [inference]

lipoprotein particle receptor activity [inference]

molecular adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Low-density lipoprotein receptor

Functional Category

G: Carbohydrate transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
calcium ion binding

Displaying **all 8** entries
InterPro
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
LDL receptor-like superfamily
LDLR class B repeat
Low-density lipoprotein (LDL) receptor class A repeat
Low-density lipoprotein (LDL) receptor class A, conserved site
Six-bladed beta-propeller, TolB-like

Disease

Disease Ontology

Displaying entries **1 - 10** of 12 in total

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DO ID	Disease Name	Source
DOID:10230	aortic atherosclerosis	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:1168	familial hyperlipidemia	Alliance of Genome Resources
DOID:12783	migraine without aura	Alliance of Genome Resources
DOID:13810	familial hypercholesterolemia	Alliance of Genome Resources
DOID:1883	hepatitis C	Alliance of Genome Resources
DOID:1936	atherosclerosis	Alliance of Genome Resources
DOID:2349	arteriosclerosis	Alliance of Genome Resources
DOID:3345	xanthomatosis	Alliance of Genome Resources
DOID:3393	coronary artery disease	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	16835	MGI:96765	MOUSE63178
Drosophila melanogaster	43105	FB:FBgn0051092
Caenorhabditis elegans	174116	WB:WBGene00020481
Bos taurus	281276		BOVIN32642
Rattus norvegicus	300438	RGD:2998	RATNO39967
Xenopus laevis	373644	Xenbase:XB-GENE-962375
Danio rerio	387529	ZFIN:ZDB-GENE-031217-1	DANRE31127
Danio rerio	393460	ZFIN:ZDB-GENE-040426-1254
Xenopus laevis	397757	Xenbase:XB-GENE-6252601
Ovis aries	443535		SHEEP16286

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements