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EPH receptor A4

Summary

Gene Symbol

EPHA4

Organism

Gallus gallus (chicken)

External Links

NCBI Gene: 395559
PubChem: 395559

Annotation

Keyword

ATP-binding
Cell adhesion
Cell membrane
Developmental protein
Endosome
Glycoprotein
Neurogenesis
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix
Tyrosine-protein kinase

Proteins

Displaying 1 entry
UniProt	Protein Name
Q07496	EPH-like kinase 8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
somitogenesis
protein phosphorylation	IEA	22301074
cell adhesion
transmembrane receptor protein tyrosine kinase signaling pathway	IEA	22301074
axon guidance	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

peptidyl-amino acid modification [inference]

peptidyl-tyrosine modification [inference]

peptidyl-tyrosine phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

peptidyl-amino acid modification [inference]

peptidyl-tyrosine modification [inference]

peptidyl-tyrosine phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

peptidyl-amino acid modification [inference]

peptidyl-tyrosine modification [inference]

peptidyl-tyrosine phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

peptidyl-amino acid modification [inference]

peptidyl-tyrosine modification [inference]

peptidyl-tyrosine phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

peptidyl-amino acid modification [inference]

peptidyl-tyrosine modification [inference]

peptidyl-tyrosine phosphorylation

cellular process [inference]

cell adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

ephrin receptor signaling pathway

cell recognition [inference]

neuron recognition [inference]

axonal fasciculation [inference]

fasciculation of sensory neuron axon

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

neuron projection fasciculation [inference]

axonal fasciculation [inference]

fasciculation of sensory neuron axon

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

anterior/posterior pattern specification [inference]

somitogenesis

segmentation

somitogenesis

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

somitogenesis

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

ephrin receptor signaling pathway

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of binding [inference]

positive regulation of GTP binding [inference]

positive regulation of guanyl-nucleotide exchange factor activity [inference]

positive regulation of Rho guanyl-nucleotide exchange factor activity

regulation of catalytic activity [inference]

regulation of hydrolase activity [inference]

regulation of GTPase activity

regulation of guanyl-nucleotide exchange factor activity [inference]

positive regulation of guanyl-nucleotide exchange factor activity [inference]

positive regulation of Rho guanyl-nucleotide exchange factor activity

regulation of binding [inference]

positive regulation of binding [inference]

positive regulation of GTP binding [inference]

positive regulation of guanyl-nucleotide exchange factor activity [inference]

positive regulation of Rho guanyl-nucleotide exchange factor activity

regulation of GTP binding [inference]

positive regulation of GTP binding [inference]

positive regulation of guanyl-nucleotide exchange factor activity [inference]

positive regulation of Rho guanyl-nucleotide exchange factor activity

regulation of guanyl-nucleotide exchange factor activity [inference]

positive regulation of guanyl-nucleotide exchange factor activity [inference]

positive regulation of Rho guanyl-nucleotide exchange factor activity

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cytoplasm
plasma membrane	IEA	22301074
dendrite
early endosome membrane
neuron projection	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

early endosome membrane

bounding membrane of organelle [inference]

endosome membrane [inference]

early endosome membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

dendrite

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein kinase activity
GPI-linked ephrin receptor activity
transmembrane-ephrin receptor activity	IEA	30032202
protein binding	IEA	22301074
ATP binding	IEA	22301074

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

ephrin receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

ephrin receptor activity [inference]

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

ephrin receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

ephrin receptor activity [inference]

catalytic activity, acting on a protein [inference]

protein kinase activity

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

ephrin receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

ephrin receptor activity [inference]

binding [inference]

protein binding

protein domain specific binding [inference]

DH domain binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

ephrin receptor activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Eph receptor

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
ATP binding
ephrin receptor activity
ephrin receptor signaling pathway
nucleotide binding
transmembrane receptor protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase signaling pathway
transmembrane-ephrin receptor activity

Displaying entries **1 - 10** of 16 in total

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InterPro
Ephrin receptor ligand binding domain
Ephrin receptor type-A /type-B
Ephrin receptor, transmembrane domain
Fibronectin type III superfamily
Fibronectin type III
Galactose-binding-like domain superfamily
Immunoglobulin-like fold
Protein kinase domain
Protein kinase, ATP binding site
Protein kinase-like domain superfamily