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DNA ligase 1

Summary

Gene Symbol

LIG1

Organism

Homo sapiens (human)

External Links

NCBI Gene

3978

PubChem

3978

Alliance of Genome Resources

HGNC:6598

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Alternative splicing
Cell division
DNA recombination
DNA repair
DNA replication
Disease variant
Ligase
Magnesium
Metal-binding
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying **all 5** entries
UniProt	Protein Name
P18858	DNA ligase I Polydeoxyribonucleotide synthase [ATP] 1
A0A8V8TQC4
B4DM52
F5GZ28
A0A8V8TPH8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
lagging strand elongation	IBA
anatomical structure morphogenesis	TAS	8696349
base-excision repair	IDA	19589734
Okazaki fragment processing involved in mitotic DNA replication	IBA
DNA repair	TAS	8696349

GO Hierarchy

biological process

immune system process [inference]

somatic diversification of immune receptors [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA ligation

DNA repair

base-excision repair, gap-filling

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

lagging strand elongation

DNA replication, Okazaki fragment processing [inference]

Okazaki fragment processing involved in mitotic DNA replication

DNA biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA ligation

DNA repair

base-excision repair, gap-filling

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

lagging strand elongation

DNA replication, Okazaki fragment processing [inference]

Okazaki fragment processing involved in mitotic DNA replication

DNA biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA ligation

DNA repair

base-excision repair, gap-filling

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

lagging strand elongation

DNA replication, Okazaki fragment processing [inference]

Okazaki fragment processing involved in mitotic DNA replication

DNA biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA ligation

DNA repair

base-excision repair, gap-filling

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

lagging strand elongation

DNA replication, Okazaki fragment processing [inference]

Okazaki fragment processing involved in mitotic DNA replication

DNA biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA ligation

DNA repair

base-excision repair, gap-filling

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

lagging strand elongation

DNA replication, Okazaki fragment processing [inference]

Okazaki fragment processing involved in mitotic DNA replication

DNA biosynthetic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA ligation

DNA repair

base-excision repair, gap-filling

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

lagging strand elongation

DNA replication, Okazaki fragment processing [inference]

Okazaki fragment processing involved in mitotic DNA replication

DNA biosynthetic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA ligation

DNA repair

base-excision repair, gap-filling

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

lagging strand elongation

DNA replication, Okazaki fragment processing [inference]

Okazaki fragment processing involved in mitotic DNA replication

DNA biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular process [inference]

cell cycle process [inference]

mitotic cell cycle process [inference]

Okazaki fragment processing involved in mitotic DNA replication

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA ligation

DNA repair

base-excision repair, gap-filling

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

lagging strand elongation

DNA replication, Okazaki fragment processing [inference]

Okazaki fragment processing involved in mitotic DNA replication

DNA biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA ligation

DNA repair

base-excision repair, gap-filling

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

lagging strand elongation

DNA replication, Okazaki fragment processing [inference]

Okazaki fragment processing involved in mitotic DNA replication

DNA biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA ligation

DNA repair

base-excision repair, gap-filling

DNA recombination

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

V(D)J recombination

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

lagging strand elongation

DNA replication, Okazaki fragment processing [inference]

Okazaki fragment processing involved in mitotic DNA replication

DNA biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cell division

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

developmental process [inference]

anatomical structure morphogenesis

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

Displaying **all 4** entries
GO Term	Evidence Code	PMID
intracellular membrane-bounded organelle	IDA
nucleoplasm	IDA TAS
mitochondrion	IBA
nucleus	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	19336415
DNA binding	IEA
DNA ligase (ATP) activity	IBA
metal ion binding	IEA
DNA ligase activity	IDA IMP TAS	15871698 9809069

GO Hierarchy

molecular function

catalytic activity [inference]

ligase activity [inference]

ligase activity, forming phosphoric ester bonds [inference]

DNA ligase activity

DNA ligase (ATP) activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA ligase activity

DNA ligase (ATP) activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dna ligase

Functional Category

J: Translation, ribosomal structure and biogenesis
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
ATP binding
DNA biosynthetic process
DNA ligase (ATP) activity
DNA ligase activity
DNA recombination
DNA repair
ligase activity
nucleotide binding

Displaying **all 7** entries
InterPro
DNA ligase, ATP-dependent, C-terminal
DNA ligase, ATP-dependent, N-terminal domain superfamily
DNA ligase, ATP-dependent, N-terminal
DNA ligase, ATP-dependent, central
DNA ligase, ATP-dependent, conserved site
DNA ligase, ATP-dependent
Nucleic acid-binding, OB-fold

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:162	cancer	Alliance of Genome Resources
DOID:612	primary immunodeficiency disease	Alliance of Genome Resources
DOID:655	inherited metabolic disorder	Alliance of Genome Resources
DOID:7725	epilepsy with generalized tonic-clonic seizures	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 50** of 60 in total

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Species	Gene ID	Orthologous MAtrix
Salmo salar	106569579	SALSA37477
Equus asinus asinus	106838232	EQUAS26589
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Sinocyclocheilus grahami	107600072	SINGR29195
Ictalurus punctatus	108261058	ICTPU00027
Rhinopithecus bieti	108540136	RHIBE04474
Cyprinus carpio carpio	109108561	CYPCA40982
Phascolarctos cinereus	110220175	PHACI19029
Vulpes vulpes	112931262	VULVU26919
Pseudonaja textilis	113448488	PSETE22210

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UniCarb-DR

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements