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fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) S homeolog

Summary

Gene Symbol

fgfr3.S

Organism

Xenopus laevis (African clawed frog)

External Links

NCBI Gene

399347

PubChem

399347

Alliance of Genome Resources

Xenbase:XB-GENE-17330101

Annotation

Keyword

ATP-binding
Apoptosis
Cell membrane
Disulfide bond
Glycoprotein
Immunoglobulin domain
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix
Tyrosine-protein kinase

Proteins

Displaying 1 entry
UniProt	Protein Name
O42127

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
positive regulation of cell population proliferation	IEA
fibroblast growth factor receptor signaling pathway	IEA
positive regulation of MAPK cascade	IEA
protein phosphorylation	IEA
apoptotic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

fibroblast growth factor receptor signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation

protein phosphorylation

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of kinase activity

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of kinase activity

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of kinase activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

positive regulation of phosphorylation [inference]

positive regulation of kinase activity

regulation of kinase activity [inference]

positive regulation of kinase activity

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of kinase activity

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of kinase activity

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of kinase activity

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

fibroblast growth factor receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of kinase activity

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of kinase activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

positive regulation of phosphorylation [inference]

positive regulation of kinase activity

regulation of kinase activity [inference]

positive regulation of kinase activity

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of kinase activity

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of kinase activity

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of transferase activity [inference]

positive regulation of kinase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of transferase activity [inference]

positive regulation of kinase activity

regulation of transferase activity [inference]

regulation of kinase activity [inference]

positive regulation of kinase activity

positive regulation of transferase activity [inference]

positive regulation of kinase activity

Displaying **all 3** entries
GO Term	Evidence Code	PMID
membrane	IEA
receptor complex	IEA
plasma membrane	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

membrane

plasma membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
fibroblast growth factor binding	IEA
transmembrane receptor protein tyrosine kinase activity	IEA
protein tyrosine kinase activity	IEA
ATP binding	IEA
fibroblast growth factor receptor activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

fibroblast growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

fibroblast growth factor receptor activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

fibroblast growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

fibroblast growth factor receptor activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

fibroblast growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

fibroblast growth factor receptor activity

binding [inference]

protein binding [inference]

growth factor binding [inference]

fibroblast growth factor binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

fibroblast growth factor receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Fibroblast growth factor receptor

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
ATP binding
fibroblast growth factor receptor activity
nucleotide binding
transmembrane receptor protein tyrosine kinase activity

Displaying entries **1 - 10** of 12 in total

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InterPro
Immunoglobulin I-set
Immunoglobulin subtype 2
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold
Protein kinase domain
Protein kinase, ATP binding site
Protein kinase-like domain superfamily
Serine-threonine/tyrosine-protein kinase, catalytic domain

Disease

Disease Ontology

Displaying entries **1 - 10** of 23 in total

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DO ID	Disease Name	Source
DOID:0050866	oral squamous cell carcinoma	Alliance of Genome Resources
DOID:0050920	tonsil squamous cell carcinoma	Alliance of Genome Resources
DOID:0060703	Muenke Syndrome	Alliance of Genome Resources
DOID:0080041	hypochondroplasia	Alliance of Genome Resources
DOID:0081371	lacrimoauriculodentodigital syndrome 2	Alliance of Genome Resources
DOID:0111158	SADDAN	Alliance of Genome Resources
DOID:0111160	camptodactyly-tall stature-scoliosis-hearing loss syndrome	Alliance of Genome Resources
DOID:0111161	Crouzon syndrome-acanthosis nigricans syndrome	Alliance of Genome Resources
DOID:0111162	epidermal nevus	Alliance of Genome Resources
DOID:11054	urinary bladder cancer	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **227** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Homo sapiens	2260	9606_0:003dae
Homo sapiens	2261		HGNC:3690
Bos taurus	281768	9913_0:004a17
Macaca mulatta	700126	9544_0:0023c4
Monodelphis domestica	100029852	13616_0:0001cc
Equus caballus	100057614	9796_0:0049ec
Ornithorhynchus anatinus	100074240	9258_0:0014d1
Sus scrofa	100153248	9823_0:00411c
Pongo abelii	100174545	9601_0:0022aa
Xenopus tropicalis	100196923	8364_0:00036a	Xenbase:XB-GENE-479255

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements