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lectin, mannose binding 1

Summary

Gene Symbol

LMAN1

Aliases

ERGIC-53
ERGIC53
FMFD1
MCFD1
MR60
endoplasmic reticulum-golgi intermediate compartment protein 53
gp58

Organism

Homo sapiens (human)

External Links

NCBI Gene

3998

HGNC

6631

KEGG Gene ID

hsa:3998

PubChem

3998

Alliance of Genome Resources

HGNC:6631

Annotation

Keyword

3D-structure
Direct protein sequencing
Disulfide bond
ER-Golgi transport
Endoplasmic reticulum
Golgi apparatus
Lectin
Metal-binding
Phosphoprotein
Protein transport
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P49257	ER-Golgi intermediate compartment 53 kDa protein Gp58 Intracellular mannose-specific lectin MR60 Lectin mannose-binding 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
negative regulation of protein targeting to mitochondrion	HMP	24270810
Golgi organization	IMP	18287528
positive regulation of organelle organization	IMP	18287528
endoplasmic reticulum to Golgi vesicle-mediated transport	IBA
early endosome to Golgi transport	IMP	18287528

GO Hierarchy

biological process

cellular process [inference]

protein folding

vesicle-mediated transport [inference]

endosomal transport [inference]

retrograde transport, endosome to Golgi [inference]

early endosome to Golgi transport

Golgi vesicle transport [inference]

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum

endoplasmic reticulum to Golgi vesicle-mediated transport

endosomal transport [inference]

retrograde transport, endosome to Golgi [inference]

early endosome to Golgi transport

cytosolic transport [inference]

retrograde transport, endosome to Golgi [inference]

early endosome to Golgi transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

multicellular organismal process [inference]

coagulation [inference]

blood coagulation

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endosomal transport [inference]

retrograde transport, endosome to Golgi [inference]

early endosome to Golgi transport

Golgi vesicle transport [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum

endoplasmic reticulum to Golgi vesicle-mediated transport

endosomal transport [inference]

retrograde transport, endosome to Golgi [inference]

early endosome to Golgi transport

cytosolic transport [inference]

retrograde transport, endosome to Golgi [inference]

early endosome to Golgi transport

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum

endoplasmic reticulum to Golgi vesicle-mediated transport

endosomal transport [inference]

retrograde transport, endosome to Golgi [inference]

early endosome to Golgi transport

cytosolic transport [inference]

retrograde transport, endosome to Golgi [inference]

early endosome to Golgi transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum

endoplasmic reticulum to Golgi vesicle-mediated transport

endosomal transport [inference]

retrograde transport, endosome to Golgi [inference]

early endosome to Golgi transport

cytosolic transport [inference]

retrograde transport, endosome to Golgi [inference]

early endosome to Golgi transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein targeting [inference]

regulation of protein targeting to mitochondrion [inference]

negative regulation of protein targeting to mitochondrion

regulation of establishment of protein localization to mitochondrion [inference]

regulation of protein targeting to mitochondrion [inference]

negative regulation of protein targeting to mitochondrion

negative regulation of establishment of protein localization to mitochondrion [inference]

negative regulation of protein targeting to mitochondrion

negative regulation of establishment of protein localization [inference]

negative regulation of establishment of protein localization to mitochondrion [inference]

negative regulation of protein targeting to mitochondrion

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of establishment of protein localization to mitochondrion [inference]

negative regulation of protein targeting to mitochondrion

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of organelle organization

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of establishment of protein localization to mitochondrion [inference]

negative regulation of protein targeting to mitochondrion

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of organelle organization

negative regulation of cellular process [inference]

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of establishment of protein localization to mitochondrion [inference]

negative regulation of protein targeting to mitochondrion

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization

positive regulation of cellular component organization [inference]

positive regulation of organelle organization

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein targeting [inference]

regulation of protein targeting to mitochondrion [inference]

negative regulation of protein targeting to mitochondrion

regulation of establishment of protein localization to mitochondrion [inference]

regulation of protein targeting to mitochondrion [inference]

negative regulation of protein targeting to mitochondrion

negative regulation of establishment of protein localization to mitochondrion [inference]

negative regulation of protein targeting to mitochondrion

negative regulation of establishment of protein localization [inference]

negative regulation of establishment of protein localization to mitochondrion [inference]

negative regulation of protein targeting to mitochondrion

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of establishment of protein localization to mitochondrion [inference]

negative regulation of protein targeting to mitochondrion

regulation of biological quality [inference]

regulation of body fluid levels [inference]

hemostasis [inference]

blood coagulation

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
ER to Golgi transport vesicle membrane
endoplasmic reticulum-Golgi intermediate compartment membrane
COPII-coated ER to Golgi transport vesicle	IBA
endoplasmic reticulum-Golgi intermediate compartment	IBA IDA	15308636 21525244
endoplasmic reticulum	IDA	19401338

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

ER to Golgi transport vesicle membrane

coated vesicle membrane [inference]

ER to Golgi transport vesicle membrane

bounding membrane of organelle [inference]

Golgi membrane

transport vesicle membrane [inference]

ER to Golgi transport vesicle membrane

coated vesicle membrane [inference]

ER to Golgi transport vesicle membrane

endoplasmic reticulum-Golgi intermediate compartment membrane

sarcomere

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

COPII-coated ER to Golgi transport vesicle

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

COPII-coated ER to Golgi transport vesicle

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

COPII-coated ER to Golgi transport vesicle

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 4** entries
GO Term	Evidence Code	PMID
mannose binding	IBA
metal ion binding	EXP	24498414
protein binding	IPI	16304051 17805346 17971482 18287528 19787799 20138881 20142513 22337587 24806965 31142615 9774442
unfolded protein binding		9546392

GO Hierarchy

molecular function

binding [inference]

protein binding

unfolded protein binding

carbohydrate binding [inference]

monosaccharide binding [inference]

mannose binding

small molecule binding [inference]

monosaccharide binding [inference]

mannose binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000074695

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K10080

Name

lectin, mannose-binding 1

References

13130098

Disease

Disease Ontology

Displaying entries **1 - 10** of 29 in total

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DO ID	Disease Name	Source
DOID:0111401	congenital dyserythropoietic anemia type II	DisGeNET
DOID:11249	vitamin K deficiency bleeding	DisGeNET
DOID:1205	allergic disease	DisGeNET
DOID:12134	factor VIII deficiency	DisGeNET DisGeNET
DOID:12365	malaria	DisGeNET
DOID:1247	blood coagulation disease	DisGeNET DisGeNET
DOID:1338	congenital dyserythropoietic anemia	DisGeNET
DOID:13481	thanatophoric dysplasia	DisGeNET
DOID:13739	nutmeg liver	DisGeNET
DOID:162	cancer	DisGeNET

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000132	Menorrhagia
HP:0000225	Gingival bleeding
HP:0000421	Epistaxis
HP:0000790	Hematuria
HP:0000978	Bruising susceptibility
HP:0001892	Abnormal bleeding
HP:0002149	Hyperuricemia
HP:0002170	Intracranial hemorrhage
HP:0002239	Gastrointestinal hemorrhage

Displaying **all 2** entries
Disease ID	Disease Name
ORPHA:35909	combined deficiency of factor V and factor VIII
OMIM:227300	factor V and factor VIII, combined deficiency of, type 1

PubChem Disease

MedGen Diseases

Factor V and factor VIII, combined deficiency of, type 1

OMIM Phenotypes

FACTOR V AND FACTOR VIII, COMBINED DEFICIENCY OF, 1; F5F8D1

KEGG Diseases

Combined deficiency of factors V and VIII

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	172799	WB:WBGene00002070
Drosophila melanogaster	44679	FB:FBgn0035909
Callorhinchus milii	103184873		CALMI30875
Danio rerio	559775	ZFIN:ZDB-GENE-060201-4
Ictalurus punctatus	108279223		ICTPU11310
Electrophorus electricus	113590542		ELEEL45211
Salmo trutta	115149477		SALTR18438
Salmo trutta	115159076		SALTR70645
Oryzias latipes	101167807		ORYLA02535
Xenopus laevis	394295	Xenbase:XB-GENE-866187

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements