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RAB44, member RAS oncogene family

Summary

Gene Symbol

RAB44

Organism

Homo sapiens (human)

External Links

NCBI Gene

401258

PubChem

401258

Alliance of Genome Resources

HGNC:21068

JoGo

RAB44

TogoVar

RAB44

Annotation

Keyword

Cell membrane
Coiled coil
GTP-binding
Hydrolase
Lysosome
Magnesium
Metal-binding
Prenylation
Proteomics identification
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q7Z6P3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
histamine secretion by mast cell	IEA
vesicle-mediated transport	IBA
histamine secretion mediated by IgE immunoglobulin	IEA

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

inflammatory response to antigenic stimulus [inference]

histamine secretion mediated by immunoglobulin [inference]

histamine secretion mediated by IgE immunoglobulin

cellular process [inference]

vesicle-mediated transport

exocytic process [inference]

histamine secretion by mast cell

export from cell [inference]

secretion by cell [inference]

signal release [inference]

hormone secretion [inference]

histamine secretion involved in inflammatory response [inference]

histamine secretion by mast cell

histamine secretion mediated by immunoglobulin [inference]

histamine secretion mediated by IgE immunoglobulin

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response [inference]

inflammatory response to antigenic stimulus [inference]

histamine secretion mediated by immunoglobulin [inference]

histamine secretion mediated by IgE immunoglobulin

immune response [inference]

inflammatory response to antigenic stimulus [inference]

histamine secretion mediated by immunoglobulin [inference]

histamine secretion mediated by IgE immunoglobulin

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to histamine [inference]

histamine secretion mediated by immunoglobulin [inference]

histamine secretion mediated by IgE immunoglobulin

response to organic cyclic compound [inference]

response to histamine [inference]

histamine secretion mediated by immunoglobulin [inference]

histamine secretion mediated by IgE immunoglobulin

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to histamine [inference]

histamine secretion mediated by immunoglobulin [inference]

histamine secretion mediated by IgE immunoglobulin

localization [inference]

establishment of localization [inference]

transport [inference]

hormone transport [inference]

hormone secretion [inference]

histamine secretion involved in inflammatory response [inference]

histamine secretion by mast cell

histamine secretion mediated by immunoglobulin [inference]

histamine secretion mediated by IgE immunoglobulin

vesicle-mediated transport

secretion [inference]

histamine secretion [inference]

histamine secretion involved in inflammatory response [inference]

histamine secretion by mast cell

histamine secretion mediated by immunoglobulin [inference]

histamine secretion mediated by IgE immunoglobulin

secretion by cell [inference]

signal release [inference]

hormone secretion [inference]

histamine secretion involved in inflammatory response [inference]

histamine secretion by mast cell

histamine secretion mediated by immunoglobulin [inference]

histamine secretion mediated by IgE immunoglobulin

organic substance transport [inference]

histamine transport [inference]

histamine secretion [inference]

histamine secretion involved in inflammatory response [inference]

histamine secretion by mast cell

histamine secretion mediated by immunoglobulin [inference]

histamine secretion mediated by IgE immunoglobulin

nitrogen compound transport [inference]

histamine transport [inference]

histamine secretion [inference]

histamine secretion involved in inflammatory response [inference]

histamine secretion by mast cell

histamine secretion mediated by immunoglobulin [inference]

histamine secretion mediated by IgE immunoglobulin

export from cell [inference]

secretion by cell [inference]

signal release [inference]

hormone secretion [inference]

histamine secretion involved in inflammatory response [inference]

histamine secretion by mast cell

histamine secretion mediated by immunoglobulin [inference]

histamine secretion mediated by IgE immunoglobulin

establishment of localization in cell [inference]

histamine secretion by mast cell

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone transport [inference]

hormone secretion [inference]

histamine secretion involved in inflammatory response [inference]

histamine secretion by mast cell

histamine secretion mediated by immunoglobulin [inference]

histamine secretion mediated by IgE immunoglobulin

Displaying **all 3** entries
GO Term	Evidence Code	PMID
plasma membrane	TAS
azurophil granule membrane	TAS
specific granule membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane [inference]

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane [inference]

azurophil granule membrane

secretory granule membrane [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
GTPase activity	IBA
calcium ion binding	IEA
GTP binding	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

GTPase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

cation binding [inference]

metal ion binding [inference]

calcium ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ras-related protein Rab-44

Functional Category

G: Carbohydrate transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
GTP binding
calcium ion binding
nucleotide binding

Displaying 1 entry
InterPro
EF-hand domain pair

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026

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